Expression of Foxp3 and interleukin-17 in lichen planus lesions with emphasis on difference in oral and cutaneous variants

Shen, Zhenhua; Gao, Xing; Ma, Liwei; Zhou, Zengtong; Shen, Xuemin; Liu, Wei

doi:10.1007/s00403-013-1429-3

Cited by 47 publications

(49 citation statements)

References 26 publications

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“…cells in OLP than in the NSI group and that they were situated in the superficial connective tissue, subjacent the epithelium corroborating the results of others [16,18,20]. Double IF demonstrated that the FoxP3 ?…”

Section: Discussionsupporting

confidence: 91%

“…cells were infrequent overall, but were more common in the NSI tissues than the OLP tissues, and were found deeper in the connective tissue. These findings contrast with the reports from others [13,18], who described more sub-epithelial IL17 ? cells in OLP in comparison with normal mucosal controls.…”

Section: Discussioncontrasting

confidence: 86%

“…Higher numbers of FoxP3 ? Tregs have been found in the local environment of OLP by comparison with controls [16,18,20], suggesting that these cells are involved in the pathogenesis of the disease.…”

Section: Introductionmentioning

confidence: 96%

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Regulation of immune cells in oral lichen planus

et al. 2015

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Oral lichen planus (OLP) is an immunological disease and while it is understood that the T cell subsets, FoxP3(+) Tregs and IL17(+) Th17 cells are involved in immune regulation, little is known about their presence in OLP. The aims of this study were to compare the number of cells expressing FoxP3 or IL-17 in OLP with non-specifically inflamed oral mucosa and to determine which cell types expressed FoxP3 and/or IL-17 and their distribution. Immunohistochemistry was used to investigate the presence of FoxP3(+) or IL-17(+) cells in 12 control cases and 17 cases of OLP. These results were analysed quantitatively and qualitatively. Double-labelling immunofluorescence (IF) was used to determine the type of cell expressing FoxP3/IL-17 and these results were analysed qualitatively. OLP displayed significantly more FoxP3(+) cells (mean 79.3 vs. 20.6 cells/defined area, p < 0.0001) and fewer IL-17(+) cells (mean 1.05 vs. 3.30 cells/defined area, p = 0.0003) than non-specific inflammatory cases. The majority of FoxP3(+) cells were in the sub-epithelial infiltrate, while IL-17(+) cells were deeper in the stromal tissues. IF showed that FoxP3(+) cells co-localised with T cells, while the IL-17(+) cells did not. These results show that the balance between Tregs and IL-17(+) cells is altered in OLP, thus supporting the proposition that disturbance in local immune regulation is important in the pathogenesis of OLP. The observation that the IL-17(+) cells were mast cells has not previously been reported in OLP and again raises questions about the role of mast cells in this condition.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 86%

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Regulation of immune cells in oral lichen planus

et al. 2015

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“…15 CD4þCD25þ Foxp3þ regulatory T cells have been shown to be associated with OLP, 30,44,51 as has dysregulation of Th17 cells 45,51 and the presence of CD3-IL-17þ cells. 15 Furthermore, the disturbed balance between Foxp3þ cells and IL-17 cells in OLP suggests altered local immune regulation.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

et al. 2017

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Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Clinical data were based on a clinical disease activity index, oral and periodontal examination parameters, and full-mouth dental radiographs. The histopathological and immunohistochemical data were based on oral mucosal samples obtained from erosive or ulcerated areas. Our findings revealed that canine chronic stomatitis is clinically characterized by painful oral mucosal ulcers of varying size, pattern, appearance, and distribution, most often associated with teeth with early periodontitis. Histologic examination revealed a subepithelial lichenoid band (interface mucositis) where B cells, T cells, and Forkheadbox protein 3 (FoxP3)-and interleukin-17-expressing cells were present. These cells might play a role in the underlying immune response and an immune-mediated pathogenesis is suspected. The clinical and histopathologic features of this chronic inflammatory mucosal disease in dogs resemble those of oral lichen planus in humans.

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“…In 2014, Shen et al . demonstrated the increased expression of Foxp3 and IL‐17 in LP lesions including oral and cutaneous variants.…”

Section: Pathogenesismentioning

confidence: 99%