Expression of Fragile Histidine Triad (FHIT) and WW-Domain Oxidoreductase Gene (WWOX) in Nasopharyngeal Carcinoma

Chen, Xu; Li, Ping; Yang, Zheng; Mo, Wuning

doi:10.7314/apjcp.2013.14.1.165

Cited by 17 publications

(13 citation statements)

References 45 publications

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“…However, we also found no correlation between the promoter methylation gene and different clinical stage / histological grade of lung cancer. These observations suggest that there were a significant statistical association of the promoter methylation of the individual gene with lung cancer risk, the aberrant methylation of combination of any two or all together genes may be associated with clinical stage in lung cancer patients and involved in the initiation of lung cancer tumorigenesis (Grote et al, 2006;Hesson et al, 2007;Missaoui et al, 2010;Li et al, 2012;Ko et al, 2013;Moison et al, 2013;Liu et al, 2013;Vo et al, 2013;Chen et al, 2013;Bodoor et al, 2014). The methylation of FHIT, RASSF1A and RARβ genes may be a molecular marker for early diagnosis of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Combined Effects Methylation of FHIT, RASSF1A and RARβ Genes on Non-Small Cell Lung Cancer in the Chinese Population

Li¹,

Deng²,

Tang³

2014

Asian Pacific Journal of Cancer Prevention

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Epigenetic modifications of tumour suppressor genes are involved in all kinds of human cancer. Aberrant promoter methylation is also considered to play an essential role in development of lung cancer, but the pathogenesis remains unclear.We collected the data of 112 subjects, including 56 diagnosed patients with lung cancer and 56 controls without cancer. Methylation of the FHIT, RASSF1A and RAR-β genes in DNA from all samples and the corresponding gene methylation status were assessed using the methylation-specific polymerase chain reaction (PCR, MSP). The results showed that the total frequency of separate gene methylation was significantly higher in lung cancer compared with controls (33.9-85.7 vs 0 %) (p<0.01).Similar outcomes were obtained from the aberrant methylation of combinations of any two or three genes (p<0.01). There was a tendency that the frequency of combinations of any two or three genes was higher in stageⅠ+Ⅱ than that in stage Ⅲ+Ⅳ with lung cancer. However, no significant difference was found across various clinical stages and clinic pathological gradings of lung cancer (p>0.05).These observations suggest that there is a significant association of promoter methylation of individual genes with lung cancer risk, and that aberrant methylation of combination of any two or three genes may be associated with clinical stage in lung cancer patients and involved in the initiation of lung cancer tumorigenesis. Methylation of FHIT, RASSF1A and RARβ genes may be related to progression of lung oncogenesis.

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Section: Discussionmentioning

confidence: 99%

Combined Effects Methylation of FHIT, RASSF1A and RARβ Genes on Non-Small Cell Lung Cancer in the Chinese Population

Li¹,

Deng²,

Tang³

2014

Asian Pacific Journal of Cancer Prevention

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“…Several studies have demonstrated an association between FHIT hypermethylation and an increased risk of non-small-cell lung carcinoma (NSCLC) (13), breast cancer (14,15), cervical cancer (16), hepatocellular carcinoma (17) and thyroid carcinoma (18). Furthermore, downregulation of FHIT expression has been observed in acute lymphoblastic leukemia (ALL) (19), gastric cancer (20), colon adenocarcinoma (21), nasopharyngeal carcinoma (22) and colorectal cancer (23).…”

Section: Introductionmentioning

confidence: 99%

FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia

et al. 2017

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Abstract. Fragile histidine triad (FHIT) is a tumor suppressor gene, which is involved in several malignancies. Epigenetic alterations in FHIT have been hypothesized to contribute to tumorigenesis. The present study aimed to examine DNA promoter methylation and gene expression levels of FHIT in childhood acute lymphoblastic leukemia (ALL), in a sample of Iranian patients. The promoter methylation status of FHIT was analyzed in 100 patients diagnosed with ALL and 120 healthy control patients. mRNA expression levels were assessed in 30 new cases of ALL compared with 32 healthy controls. Hypermethylation of the FHIT promoter was significantly more frequent in patients with ALL than in healthy controls (OR=3.83, 95% CI=1.51-9.75, P=0.007). Furthermore, FHIT mRNA expression levels were significantly reduced in childhood ALL patients compared with healthy controls (P=0.032). The results of the present study revealed that dysregulation of the FHIT gene may contribute to the pathogenesis of childhood ALL. Future studies investigating a larger sample population with greater ethnic diversity would be beneficial, to confirm the results from the present study.

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“…FHIT promoter hypermethylation was positively linked to tumor staging, pathological grade, or lymph node metastasis of colorectal cancer [ 59 ], thyroid cancer [ 49 ] and lung cancer [ 60 ]. Chen et al [ 61 ] found that FHIT mRNA expression had an inverse relation with larger invasive range, poor histological differentiation and advanced clinical stage of nasopharyngeal carcinoma. Yin et al [ 54 ] reported that homozygous deletion of exon 5 of FHIT was positively associated with lymph node metastasis of differentiated thyroid cancer and the homozygous deletion of exon 8 was positively associated with the tumor pathological grade, TNM staging, and lymph node metastasis of differentiated thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

FHIT down-regulation was inversely linked to aggressive behaviors and adverse prognosis of gastric cancer: a meta- and bioinformatics analysis

Zheng

Liu

2017

Oncotarget

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FHIT (fragile histine triad) acts as diadenosine P1, P3-bis (5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism, and induces apoptosis as a tumor suppressor. We performed a systematic meta- and bioinformatics analysis through multiple online databases up to March 14, 2017. The down-regulated FHIT expression was found in gastric cancer, compared with normal mucosa and dysplasia ( p < 0.05). FHIT expression was negatively with depth of invasion, lymph node metastasis, distant metastasis, TNM staging and dedifferentiation of gastric cancer ( p < 0.05). A positive association between FHIT expression and favorable overall survival was found in patients with gastric cancer ( p < 0.05). According to Kaplan-Meier plotter, we found that a higher FHIT expression was negatively correlated with overall and progression-free survival rates of all cancer patients, even stratified by aggressive parameters ( p < 0.05). These findings indicated that FHIT expression might be employed as a potential marker to indicate gastric carcinogenesis and subsequent progression, even prognosis.

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Expression of Fragile Histidine Triad (FHIT) and WW-Domain Oxidoreductase Gene (WWOX) in Nasopharyngeal Carcinoma

Cited by 17 publications

References 45 publications

Combined Effects Methylation of FHIT, RASSF1A and RARβ Genes on Non-Small Cell Lung Cancer in the Chinese Population

Combined Effects Methylation of FHIT, RASSF1A and RARβ Genes on Non-Small Cell Lung Cancer in the Chinese Population

FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia

FHIT down-regulation was inversely linked to aggressive behaviors and adverse prognosis of gastric cancer: a meta- and bioinformatics analysis

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