Expression of genes involved in retinoic acid biosynthesis in human gastric cancer

Kropotova, Ekaterina S.; Zinov’eva, O. L.; Zyryanova, Alisa; Чойнзонов, Е. Л.; Афанасьев, С. Г.; Чердынцева, Н. В.; Beresten, S. F.; Oparina, N. Yu.; Mashkova, T. D.

doi:10.1134/s0026893313020076

Cited by 16 publications

(13 citation statements)

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“…However, even if in lung, breast, and hepatic cancers this relation is quite established, in gastric and colon cancers the topic is still open. Indeed, Ohashi and colleagues found conflicting results in comparison to previous cited of Kropotova and co-workers [82] recording a lower expression of AKR1B10 in colorectal cancers and adenomas in comparison to normal tissues [91]. Similarly, Yao and colleagues found AKR1B10 down-regulation in gastric cancer compared with paired normal mucosa, contrary to what was found by Kropotova and colleagues [83,92].…”

Section: Metabolic Enzymesmentioning

confidence: 87%

“…Moreover, in both papers the mRNA's decrease of RALDH1 enzyme, responsible for the irreversible oxidation of retinaldehyde to ATRA, was found. In colorectal cancer this decrease was also accompanied by an increase in the expression of the ATRA-degrading cytochrome CYP26A1, whereas in gastric cancer these enzymes were unaltered [82,83]. The same authors also correlated the decreased expression of ADH1B and ADH1C with advanced stages of colorectal carcinomas, overall indicating that dysregulation of the ATRA biosynthesis can be responsible of the cancer progression [83].…”

Section: Metabolic Enzymesmentioning

confidence: 91%

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Retinoic Acids in the Treatment of Most Lethal Solid Cancers

Costantini

Molinari

Farinon

et al. 2020

JCM

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Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present review the literature about the top five lethal solid cancers (lung, stomach, liver, breast, and colon cancer), as defined by The Global Cancer Observatory of World Health Organization, and retinoic acids (ATRA, 9-cis retinoic acid, and 13-cis retinoic acid, RA) was compared. The action of retinoic acids in inhibiting the cell proliferation was found in several cell pathways and compartments: from membrane and cytoplasmic signaling, to metabolic enzymes, to gene expression. However, in parallel in the most aggressive phenotypes several escape routes have evolved conferring retinoic acids-resistance. The comparison between different solid cancer types pointed out that for some cancer types several information are still lacking. Moreover, even though some pathways and escape routes are the same between the cancer types, sometimes they can differently respond to retinoic acid therapy, so that generalization cannot be made. Further studies on molecular pathways are needed to perform combinatorial trials that allow overcoming retinoic acids resistance.

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Section: Metabolic Enzymesmentioning

confidence: 87%

Section: Metabolic Enzymesmentioning

confidence: 91%

Retinoic Acids in the Treatment of Most Lethal Solid Cancers

Costantini

Molinari

Farinon

et al. 2020

JCM

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“…3,45 ATRA AND TREG CELL FUNCTION atRA, the primary biologically active metabolite of vitamin A, plays vital roles in embryonic development, vision, skin homeostasis and reproduction, and it also crucial for maintenance of the immune system. 46 atRA produced by dendritic cells facilitates the de novo generation of Foxp3 1 Treg cells from naive CD4 1 CD25 2 T cell populations in mice, 47,48 but also suppress the de novo differentiation of naive CD4 1 cells into Th17 cells. 22 The effect of atRA on Treg and Th17 cells is dependent upon the RA receptor/retinoid X receptor heterodimer.…”

Section: Foxp3 and Treg Cell Subsetsmentioning

confidence: 99%

The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells

et al. 2015

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Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. Foxp3 1 Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.

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“…Retinoids have been used as chemotherapeutic drugs in acute promyelocytic leukemia (APL) as the antiproliferative and antioxidant activity [34]. It has been reported that the reduction in the expression of RDH12 could lead to the dysregulation of cell proliferation/ differentiation and initiate cancer development in human gastric cancer [35]. In this study, we found that the expression of RDH12 was decreased in CSCC tissues and was negatively associated with tumor size and depth of cervical invasion.…”

Section: Discussionmentioning

confidence: 77%

Transcriptome profiling of the cancer and adjacent nontumor tissues from cervical squamous cell carcinoma patients by RNA sequencing

Guo

Wang

et al. 2015

Tumor Biol.

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Cervical cancer is the third most common cancer and the fourth leading cause of cancer deaths among women in the world. The discovery of vital diagnostic and therapeutic markers against cervical squamous cell carcinoma (CSCC) would broaden our understanding on the molecular basis of CSCC. In this study, we thoroughly analyzed the transcriptome of CSCC and matched adjacent nontumor (ATN) tissue. RNA sequencing was performed to screen the differentially expressed genes (DEGs) of three pairs of CSCC and ATN tissues. Functional enrichment analysis was used to uncover the biological functions of DEGs. Protein interaction network was carried out to reveal interaction of DEGs. Quantitative real-time PCR was conducted to validate the expression of DEGs. Immunohistochemistry was used to detect the relationship between clinicopathological parameters of CSCC and DEGs. There were a total of 347 significantly common DEGs in the three paired examples, including 104 consistent upregulated and 148 consistent downregulated DEGs. The 347 DEGs were categorized into 73 functional categories by Gene Ontology (GO) analysis. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis suggested six significantly signal pathways. The protein interaction network uncovered three important DEGs, including retinol dehydrogenase 12 (RDH12), ubiquitin D (UBD), and serum amyloid A1 (SAA1). We found that RDH12 expression was decreased in 74.5 % of CSCC tissues. RDH12 expression was negatively associated with tumor size and depth of cervical invasion. The UBD was overexpressed in 61.7 % of CSCC tissues and was positively related with tumor size and lymphatic metastasis. The SAA1 protein was overexpressed in 57.4 % of CSCC tissues and was positively related with clinicopathological parameters of tumor size, lymphatic metastasis, and depth of cervical invasion. The RDH12, UBD, and SAA1 genes might participate in the progression of CSCC.

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Expression of genes involved in retinoic acid biosynthesis in human gastric cancer

Cited by 16 publications

References 50 publications

Retinoic Acids in the Treatment of Most Lethal Solid Cancers

Retinoic Acids in the Treatment of Most Lethal Solid Cancers

The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells

Transcriptome profiling of the cancer and adjacent nontumor tissues from cervical squamous cell carcinoma patients by RNA sequencing

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