Expression of genes involved in neurogenesis, and neuronal precursor cell proliferation and development: Novel pathways of human ovarian granulosa cell differentiation and transdifferentiation capability in�vitro

Brązert, Maciej; Kranc, Wiesława; Celichowski, Piotr; Jankowski, Maurycy; Piotrowska‐Kempisty, Hanna; Pawełczyk, Leszek; Bruska, M; Zabel, Maciej; Nowicki, Michał; Kempisty, Bartosz

doi:10.3892/mmr.2020.10972

Cited by 7 publications

(6 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Formation and retention of spatial memories are controlled in the hippocampus and promoted by LTP and neurogenesis 20 , 71 . Our observation that offspring of H. bakeri infected mothers have enhanced spatial memory is consistent with previous evidence that the brains of PD 7 pups of infected dams have increased expression of LTP genes as well as the ITGA3 gene 48 , which may promote neurogenesis 72 . Further evidence for this hypothesis is found in physical exercise models, where exposure of mice to running enhances hippocampal neurogenesis and LTP which results in enhanced spatial memory performance in the Morris water maze 73 , 74 .…”

Section: Discussionsupporting

confidence: 92%

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Noel

Fortin-Hamel

Haque

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The developing brain is particularly vulnerable to factors including maternal infection during pregnancy. Establishment of neural networks critical for memory and cognition begins during the perinatal period, when Heligmosomoides bakeri, a gastrointestinal (GI) nematode restricted to the maternal mouse intestine, has been shown to upregulate expression of long-term potentiation genes in the young rodent pup brain. We explored the impact of maternal infection during pregnancy and early lactation on the spatial behavior of uninfected male and female juvenile mice. Pre-weaned pups of H. bakeri infected dams exhibited less exploratory behaviour compared to pups of uninfected dams on postnatal day (PD) 16 but not PD 17, possibly reflecting a transient fear of an unfamiliar environment and/or a brief neurodevelopmental delay. Our two spatial memory tests show for the first time an enhancement of spatial memory in response to maternal nematode infection regardless of pup sex. At PD 17, pups of infected dams expressed object location memories after 3 h in the Object Location Test whereas offspring of uninfected mothers did not. In addition, at PD 34, juveniles of infected mothers retained their ability to find the escape hole in the Barnes Maze Test for one week whereas offspring from uninfected mothers did not. This finding is even more striking given that spatial memory was positively associated with pup length, yet this maternal infection impaired linear growth of pups. Thus, the positive impact of maternal infection on spatial memory countered any impairment associated with the shorter length of the pups. Overall, these novel findings indicate that a maternal GI nematode infection during pregnancy and lactation positively influences the spatial memory of uninfected juvenile offspring with potential fitness implications for the next generation.

show abstract

Section: Discussionsupporting

confidence: 92%

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Noel

Fortin-Hamel

Haque

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Several clinical observations have indicated that Adra1d plays an essential role in central nervous system processes (Sadalge et al, 2003 ; Mishima et al, 2004 ; Aono et al, 2015 ). Cldn11, a major component of central nervous system myelin, has been reported to be involved in nerve cell formation processes (Brazert et al, 2020 ). Studies of cultured oligodendrocytes showed that Plp1 alters the expression of other myelin genes and inhibits the differentiation of oligodendrocyte precursor cells (Karim et al, 2007 ; Miyamoto et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala

Zhuang

et al. 2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Abnormality of fear memory is one of the important pathogenic factors leading to post-traumatic stress disorder (PTSD), anxiety disorder, and other mental disorders. Clinically, although exposure therapy, which is based on the principle of fear memory extinction, has a certain effect on these diseases, it still relapses frequently in some cases. These troubles can be effectively solved by retrieving the memory in a certain time window before the extinction of fear memory. Therefore, it is generally believed that the extinction of fear memory is the result of forming new safe memory to competitively inhibit the original fear memory, while the retrieval-extinction operation is the updating or erasure of the original fear memory, thus, which has greater clinical therapeutic potential. However, what are the detailed molecular networks, specifically the circular RNAs (circRNAs), involved in fear memory updating, and the differences with fear extinction, are still unknown. In this study, we systematically observed the expression of mRNAs, microRNAs (miRNA), long non-coding RNAs (lncRNAs), and circRNAs in the basolateral amygdala of mice after fear memory formation, extinction, and updating by whole-transcriptional sequencing, then a variety of inter-group comparison and bioinformatics analysis were used to find the differential expressed RNAs, enrich the function of them, and construct the molecular interaction networks. Moreover, competing endogenous RNA (ceRNA) molecular networks and transcriptional regulatory networks for the candidate circRNAs were constructed. Through these analyses, we found that about 10% of molecules were both involved in the fear memory extinction and formation, but the molecules and their signaling pathways were almost completely different between fear memory extinction and updating. This study describes a relatively detailed molecular network for fear memory updating, which might provide some novel directions for further mechanism research, and help to develop a specific physical method for fear memory intervention, based on the regulation of these key molecules.

show abstract

“…Moreover, GCs derived from human follicular fluid express luteinizing hormone receptors (LHR) and are capable of differentiation to several cell lineages e.g. osteogenic, chondrogenic, adipogenic, neurogenic under defined optimal in vitro cell culture conditions with Leukaemia Inhibitory Factor (LIF) [20,24,28,29]. Furthermore, the GCs in conditioned in vitro culture conditions express mesenchymal stem cell markers (MSCs); CD29, CD44, CD90, CD105, CD117 and CD166, without CD73 [21,30,31].…”

Section: Follicular Stem Cell Nichementioning

confidence: 99%

Follicular renewal and stemness potency of follicular cells depended of telomerase activity and TERT expression – short review

Zgórecka

Narenji

Krajnik

et al. 2022

Medical Journal of Cell Biology

Self Cite

View full text Add to dashboard Cite

Several hypotheses have been proposed, relating to the potential genesis of follicular cells in the ovarian niche. Reports using mice as an experimental model have suggested that the ovaries may contain stem cells that are likely involved in the formation of new follicles in adult reproductive life. Over recent years, various types of ovarian cells have been identified and described to confirm or disprove the existence of ovarian adult stem cells. Most research is focused on granulosa cells (GCs), which are essential for follicular development and maturation of female germ cells (oocytes). GCs exhibit the features of stem cells, such as expression of stem cell markers: OCT-4, Sox-2, Nanog as well as certain markers of mesenchymal stem cells, including CD29, CD44, CD90, CD105, CD117, and CD166. Another discovery in favor of the potential stemness of GCs is their ability to transdifferentiate towards other cell lines and high telomerase (TERT) activity in dividing compartments of the follicle during its maturation.

show abstract

Expression of genes involved in neurogenesis, and neuronal precursor cell proliferation and development: Novel pathways of human ovarian granulosa cell differentiation and transdifferentiation capability in�vitro

Cited by 7 publications

References 88 publications

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala

Follicular renewal and stemness potency of follicular cells depended of telomerase activity and TERT expression – short review

Contact Info

Product

Resources

About