Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas

Boyle, Belema; Butz, Henrietta; Láng, István; Zalatnai, Attila; Tóth, Miklós; Feldman, Karolina; Horanyi, J; Igaz, Péter; Rácz, Kàroly; Patócs, Attila

doi:10.1016/j.steroids.2010.04.008

Cited by 13 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Its presence in both cortical and medullary tumors (that is, pheochromocytomas) was also shown in the 1980s (49-51) and subsequently confirmed (12,52). More recently, a familial case of GR haploinsufficiency in conjunction with macronodular adrenal hyperplasia was reported; this finding suggested that glucocorticoid-regulated adrenocortical cell signaling may have a role in the regulation of adrenal growth (53).…”

Section: The Gr In the Adrenal Cortexmentioning

confidence: 79%

The Glucocorticoid Receptor and its Expression in the Anterior Pituitary and the Adrenal Cortex: A Source of Variation in Hypothalamic-Pituitary-Adrenal Axis Function; Implications for Pituitary and Adrenal Tumors

et al. 2011

View full text Add to dashboard Cite

Objective To review the expression of the glucocorticoid receptor (GR) in anterior pituitary and adrenocortical cells and tumors derived from these tissues as well as factors that may influence its expression. Methods We present an overview of the relevant literature, with a focus on data generated from our studies. Results The expression of the GR is an essential element of the negative feedback that closes the loop formed by corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol in the context of the hypothalamic-pituitary-adrenal (HPA) axis. Although the GR expression in anterior pituitary cells—and in particular the corticotrophs—was first demonstrated several years ago, it was not known until relatively recently where, by what cells, and in what form the GR is expressed in the adrenal cortex. The variability in the expression of the GR in pituitary and adrenocortical cells may underlie the substantial differences in HPA axis function across individuals, especially when testing for tumors associated with hypercortisolemia. This expression is influenced by a multitude of tissue-specific factors, which may explain why it is so difficult to interpret (or reproduce) studies that are based on GR functional polymorphisms on different cohorts of patients or even different sets of laboratory animals. Conclusion This review highlights the variability in expression and function of the GR in pituitary and adrenocortical cells as one of the reasons for the appreciable differences in HPA axis function across individuals. Particular attention was paid to interactions that may affect the interpretation of diagnostic testing of the HPA axis in patients with pituitary adenomas (Cushing disease) or adrenocortical tumors (Cushing syndrome).

show abstract

Section: The Gr In the Adrenal Cortexmentioning

confidence: 79%

The Glucocorticoid Receptor and its Expression in the Anterior Pituitary and the Adrenal Cortex: A Source of Variation in Hypothalamic-Pituitary-Adrenal Axis Function; Implications for Pituitary and Adrenal Tumors

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Tissue samples were fixed with formalin and embedded in paraffin. Four‐μm sections were cut, and staining was performed as described previously with some modifications. Briefly, deparaffinized and rehydrated sections were treated with microwave heat‐induced epitope retrieval for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Low expression of glucocorticoid receptor α in oral lichen planus correlates with activation of nuclear factor κB: a preliminary study

Lin

Sun

Zhen

et al. 2014

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Известно, что адренокортикотропный гормон индуцирует экспрессию микроРНК miR-142-3p, которая, в свою очередь, воздействует на глюкокортикоидные рецепторы в надпочечниках. Также имеются данные о том, что экспрессия глюкокортикоидного рецептора альфа повышена в адренокортикальных аденомах, продуцирующих кортизол, по сравнению с гормонально-неактивными аденомами и здоровыми тканями [59]. Таким образом, была выдвинута гипотеза о регуляторной петле, способствующей онкогенезу в тканях надпочечника при отсутствии белка менина: снижение экспрессии менина в адренокортикальных опухолях привело бы к снижению продукции микроРНК miR-142-3p и тем самым -к увеличению количества глюкокортикоидных рецепторов, вызывая образование опухолей.…”

Section: менин и микрорнкunclassified

The role of non-coding RNAs in the pathogenesis of multiple endocrine neoplasia syndrome type 1

Mamedova

Dimitrova

Belaya

et al. 2020

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

Changes in the expression of non-coding ribonucleic acids (ncRNAs) takes part in the formation of various tumors. Multiple endocrine neoplasia syndrome type 1 (MEN1) is a rare autosomal dominant disease caused by mutations of the MEN1 gene encoding the Menin protein. Syndrome is characterized by the occurrence of parathyroid tumors, gastroenteropancreatic neuroendocrine tumors, pituitary adenoma, as well as other endocrine and non-endocrine tumors. The mechanisms for the formation of MEN1-related tumors due to mutations in the MEN1 gene are not . In the absence of mutations of the MEN1 gene in patients with phenotypically similar features, this condition is regarded as a phenocopy of this syndrome. The cause of the combination of several MEN-1-related tumors in these patients remains unknown. The possible cause is that changes in the expression of ncRNAs affect the regulation of signaling pathways in which Menin participates and may contribute to the development of MEN-1-related tumors. The identification of even a small number of agents interacting with Menin makes a significant contribution to the improvement of knowledge about its pathophysiological influence and ways of developing tumors within the MEN-1 syndrome and its phenocopies.

show abstract

Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas

Cited by 13 publications

References 36 publications

The Glucocorticoid Receptor and its Expression in the Anterior Pituitary and the Adrenal Cortex: A Source of Variation in Hypothalamic-Pituitary-Adrenal Axis Function; Implications for Pituitary and Adrenal Tumors

The Glucocorticoid Receptor and its Expression in the Anterior Pituitary and the Adrenal Cortex: A Source of Variation in Hypothalamic-Pituitary-Adrenal Axis Function; Implications for Pituitary and Adrenal Tumors

Low expression of glucocorticoid receptor α in oral lichen planus correlates with activation of nuclear factor κB: a preliminary study

The role of non-coding RNAs in the pathogenesis of multiple endocrine neoplasia syndrome type 1

Contact Info

Product

Resources

About