Expression of glutathione-S-transferase-π in human tumours

Glutathione S-transferase: differential expression of α, μ, and π isoenzymes in benign prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma

“…This finding stands in contrast with most other cancers in which GST expression is increased, often markedly so, compared with benign tissue. For example, there is increased expression of GSTp in cancers of the breast, colon, stomach, pancreas, bladder, lung, head and neck, ovary, and cervix, as well as soft tissue sarcoma, testicular embryonal carcinoma, meningioma, and glioma [8][9][10][11][12][13][14][15][16][17][18]. Selective down-regulation of GSTa and l subclasses was observed in some cancers despite the increased expression of GST p (eg, colonic and renal cell carcinoma) [19,20].…”

Proteomics Identification of Azaspiracid Toxin Biomarkers in Blue Mussels, Mytilus edulis

“…By far the most studied function of the GST enzymes is their role in cellular detoxification (52) primarily against oxygen free radicals and peroxides produced by physiological cellular processes and exogenous stimuli. GST Pi has implications for human health where overexpression has been associated with carcinogenesis and is used as a tumor marker for gastrointestinal malignancies (53)(54)(55)(56).…”

Glutathione S-transferase-pi in malignant tissues and plasma of human colorectal and gastric cancers

“…On the other hand, previous studies have shown the importance of Table 2 Tissue GST activity and plasma GST-pi levels in patients with colorectal and gastric cancers (mean±SD). Statistical analyses were performed by using the Wilcoxon matched-pairs signed-ranks and Mann-Whitney U-Wilcoxon rank sum W tests determining plasma GST-pi levels in the assessment of cancer status of malignant tissue (Tsuchida and Sato 1992;Hirata et al 1992;Toffoli et al 1992;Niitsu et al 1989;Fan et al 1995). Plasma GST-pi levels have been observed to increase in patients with some cancers (Hirata et al 1992;Toffoli et al 1992) including colorectal and gastric cancers (Tsuchida and Sato 1992;Niitsu et al 1989;Fan et al 1995).…”