2000
DOI: 10.1016/s0303-7207(99)00199-9
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Expression of GnRH receptor gene in human ectopic endometrial cells and inhibition of their proliferation by leuprolide acetate

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Cited by 55 publications
(42 citation statements)
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“…Interestingly, similar findings were made in the Fallopian tube (40). GnRH receptors have even been detected in endometriosis: using RT-PCR and Southern blot, Borroni et al (41) were able to demonstrate the presence of these receptors in 13 of 13 samples of ovarian endometriosis; however, in cell cultures of these lesions, the GnRH agonist, leuporelin, exerted antiproliferative effects in just 5 of 13 cases. Kottler et al (42) demonstrated co-expression of GnRH and its receptor in malignant and non-malignant tissues of the human breast.…”
Section: Hypothalamic Gonadotropin-releasing Hormonementioning
confidence: 61%
“…Interestingly, similar findings were made in the Fallopian tube (40). GnRH receptors have even been detected in endometriosis: using RT-PCR and Southern blot, Borroni et al (41) were able to demonstrate the presence of these receptors in 13 of 13 samples of ovarian endometriosis; however, in cell cultures of these lesions, the GnRH agonist, leuporelin, exerted antiproliferative effects in just 5 of 13 cases. Kottler et al (42) demonstrated co-expression of GnRH and its receptor in malignant and non-malignant tissues of the human breast.…”
Section: Hypothalamic Gonadotropin-releasing Hormonementioning
confidence: 61%
“…Sequence analysis reveals no mutations or alternative splicing patterns throughout the entire coding region of endometrial GnRH receptor RNA transcripts. (Borroni et al 2000, Grundker et al 2001b.…”
Section: Interaction Of Gnrh and Gnrh-r In Reproductive Tissuesmentioning
confidence: 99%
“…Because of its unique functions, analogues of GnRH have been applied for medical treatment of many hormone-related diseases such as endometriosis. Furthermore, some studies report that the GnRH system may play a role of autocrine and paracrine regulation in endometriosis since GnRH and GnRH receptor mRNA have been detected in human eutopic and ectopic endometrium (Imai et al 1994, Borroni et al 2000. Concerning the apoptosis in endometriosis induced by GnRH analogues, it was demonstrated that GnRH analogues may have a direct effect by enhancing the apoptotic index, decreasing the secretion of promitogenic cytokines such as interleukin-1b and VEGF, increasing the expression of the pro-apoptotic proteins BAX and Fas ligand, decreasing the expression of the anti-apoptotic protein BCL2 and suppressing cell proliferation in endometriosis (Meresman et al 2003, Bilotas et al 2007).…”
Section: Gnrh and Endometriosismentioning
confidence: 99%
“…Various disease and/or transformed epithelial cells are known to express the GnRHR (Friess et al 1991, Kakar & Jennes 1995, Chatzaki et al 1996, Kottler et al 1997, Barbieri 1998, Yin et al 1998, Ortmann & Diedrich 1999, Borroni et al 2000, Halmos et al 2000, Kang et al 2000, Lee et al 2000, Noci et al 2000, and the GnRHRs present on hormonally responsive tumor cells appear to be identical to the high-affinity pituitary receptor. Recently, GnRHR-II, which transmits significantly stronger anti-proliferative effects than GnRHR-I, has been identified in ovarian and endometrial cancers (Kang et al 2000, Bedecarrats & Kaiser 2003; the significance of this remains to be determined as the role of GnRH-II has not been elucidated.…”
Section: Aberrant Expression Of Gnrhr In Cancermentioning
confidence: 99%