Expression of Group I and II Metabotropic Glutamate Receptors in Trigeminal Neurons during Postnatal Development

Turman, Jack E.; Hiyama, Lauren; Castillo, Marvin; Chandler, Scott H.

doi:10.1159/000048695

Cited by 28 publications

(17 citation statements)

References 65 publications

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“…Initial studies using electrophysiologic (Kogo et al, 1996), molecular (Kutsuwada et al, 1996), and immunohistochemical methods (Turman et al, 1999) confirmed a role for, and the developmental regulation of N-methyl-d-aspartate (NMDA) receptors in these circuits. Electrophysiologic (Del Negro and Chandler, 1998) and immunohistochemical (Turman et al, 2000) data also implicate a role for metabotropic glutamate receptors in neonatal trigeminal neurons. Little work has been done on the role of alpha-amino-d-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in neonatal brainstem circuits underlying jaw movements.…”

mentioning

confidence: 85%

“…Differences in AMPA receptor composition between rostral Me5 and caudal/middle Me5 neurons correlate with findings from previous studies in our lab. We recently showed the regional and developmental regulation of NMDA NR1 and NR2A/B subunits (Turman et al, 1999) and group I and II metabotropic glutamate receptors (Turman et al, 2000) within Me5. A striking difference between the results of the current study and our findings with NR2A/B and both group I and II mGluRs, is the absence of Me5 axonal labeling with AMPA subunits.…”

Section: Developmental Regulation Of Ampa Receptor Subunits In Me5 Nementioning

confidence: 99%

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AMPA receptor subunit expression in trigeminal neurons during postnatal development

et al. 2000

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Trigeminal motoneurons (Mo5) and mesencephalic trigeminal neurons (Me5) are important constituents of the neural circuitry responsible for jaw movements. Non-N-methyl-D-aspartate (NMDA) glutamate receptors are a critical component of the brainstem circuitry responsible for reflex and centrally activated jaw movements; however, little is known about the expression of these receptors in neonatal oral-motor circuitry. Receptor immunohistochemistry using affinity-purified polyclonal antibodies directed against GluR1, GluR2/3/4c, and GluR4, respectively, and a monoclonal antibody directed against the GluR2 subunit, were used in rats at postnatal day (P)1, P3, P5, P10, P19-21, P32-35, and P60 to describe the expression of the alpha-amino-d-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor in Mo5 and Me5 neurons. In Mo5, immunoreactivity was noted for all antibodies throughout the time frame sampled. Neurons in caudal portions of Me5 displayed immunoreactivity to each antibody except at P60 when GluR2 immunoreactivity was absent. Neurons located in rostral Me5 displayed GluR2/3/4c and GluR4 immunoreactivity throughout the time frame, GluR1 immunoreactivity emerged at P3 and a transient expression of GluR2 expression was observed between P10 and P32-35. The lack of labeling of some neurons in both regions, coupled with differences in temporal expression, suggests that there are differences in the AMPA receptor phenotype within and between Mo5 and Me5 during postnatal development. Differences in AMPA subunit composition suggest a complex role for AMPA-mediated glutamatergic neurotransmission in brainstem circuits controlling jaw movements.

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confidence: 85%

Section: Developmental Regulation Of Ampa Receptor Subunits In Me5 Nementioning

confidence: 99%

AMPA receptor subunit expression in trigeminal neurons during postnatal development

et al. 2000

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“…Evidence for differential patterns of expression during postnatal development has also been provided for group II and III mGlus (Catania et al 1994;Duvoisin et al 1995;Meguro et al 1999;Turman et al 2001;Di Giorgi Gerevini et al 2004). Among group II mGlus, mGlu2 is poorly expressed postnatally and increases in the first two weeks of life.…”

Section: Developmental Aspects Of Mglu Expressionmentioning

confidence: 96%

“…Numerous studies have shown a differential regulation of mGlu expression during CNS development (Shigemoto et al 1992;Catania et al 1994;Lopez-Bendito et al 2001;Turman et al 2001;Di Giorgi Gerevini et al 2004;Lujan et al 2005). Activation or changes in the expression of mGlus have been related to a variety of important ontogenetic events, such as neuronal migration and the formation of synaptic circuitry.…”

Section: Developmental Aspects Of Mglu Expressionmentioning

confidence: 99%

Metabotropic glutamate receptors

2006

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Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate a multitude of signalling pathways important for modulating neuronal excitability, synaptic plasticity and feedback regulation of neurotransmitter release. In this review, we summarize anatomical findings (from our work and that of other laboratories) describing their distribution in the central nervous system. Recent evidence regarding the localization of these receptors in peripheral tissues will also be examined. The distinct regional, cellular and subcellular distribution of mGlus in the brain will be discussed in view of their relationship to neurotransmitter release sites and of possible functional implications.

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“…The fraction of Glut þ boutons onto JO motoneurons (and JC motoneurons; Paik et al, 2011) did not change during development. The developmental changes of excitatory synaptic transmission in the CNS are well documented: the duration and amplitude of EPSP (Oswald and Reyes, 2008;Feldmeyer and Radnikow, 2009), the subunit composition of N-methyl-D-aspartate (NMDA) receptors, and their contribution to excitatory synaptic transmission all decline during development (Carmignoto and Vicini, 1992;Hestrin, 1992;Kalb et al, 1992;Hori and Kanda, 1996), and the expression of AMPA, NMDA, and group I and II metabotropic glutamate receptors is temporally and spatially regulated, including in the trigeminal motor nucleus (Turman et al, 1999(Turman et al, , 2000(Turman et al, , 2001(Turman et al, , 2002Ishihama et al, 2005;Ishihama and Turman, 2006). Given Figure 6.…”

Section: Formation Of Inhibitory and Excitatory Synapses On The Somatmentioning

confidence: 99%

Development of γ‐aminobutyric acid‐, glycine‐, and glutamate‐immunopositive boutons on rat jaw‐opening motoneurons

Paik

Kwak

Bae

et al. 2012

J of Comparative Neurology

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Inhibitory and excitatory synaptic inputs onto trigeminal motoneurons play an important role in coordinating jaw movements. Previously, we reported that the phenotype of the inhibitory boutons apposing the somata of jaw-closing (JC) motoneurons changes from γ-aminobutyric acid (GABA)-positive (GABA+) to predominantly glycine-positive (Gly+) during development. In the present study, we investigated the development of inhibitory and excitatory boutons apposing antagonistic jaw-opening (JO) motoneurons (anterior digastric motoneurons) at postnatal day 2 (P2), P11, and P31 in the rat. JO motoneurons were retrogradely labeled with horseradish peroxidase. Postembedding immunogold staining with antisera against GABA, Gly, and glutamate (Glut) was performed and followed by quantitative ultrastructural analysis. The size of both small and large JO motoneurons increased during development. The number of excitatory (Glut+) and inhibitory (GABA+, Gly+, and GABA+/Gly+) boutons per JO motoneuron increased significantly from P2 to P11 and then remained unchanged until P31. The time course of inhibitory synapse formation differed between JO and JC motoneurons, whereas that of excitatory synapse formation was similar between the two neuronal populations. The fraction of GABA+ boutons decreased by 86% and the fraction of GABA+/Gly+ boutons increased by 200% from P11 to P31, suggesting a switch from GABA+ to GABA+/Gly+ phenotype. The fraction of Gly+ boutons remained unchanged. These results indicate that inhibitory synapses onto somata of JO motoneurons exhibit a developmental pattern distinct from that of synapses onto JC motoneurons, which may reflect distinctive maturation of oral motor system.

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Expression of Group I and II Metabotropic Glutamate Receptors in Trigeminal Neurons during Postnatal Development

Cited by 28 publications

References 65 publications

AMPA receptor subunit expression in trigeminal neurons during postnatal development

AMPA receptor subunit expression in trigeminal neurons during postnatal development

Metabotropic glutamate receptors

Development of γ‐aminobutyric acid‐, glycine‐, and glutamate‐immunopositive boutons on rat jaw‐opening motoneurons

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