Expression of Growth Hormone Receptor, Insulin-Like Growth Factor 1 (IGF-1) and IGF-1 Receptor mRNA and Proteins in Human Skin

Tavakkol, Amir; Elder, James T.; Griffiths, Christopher E.M.; Cooper, Kevin D.; Talwar, H. S.; Fisher, Gary J.; Keane, Karen M.; Foltin, Susan K.; Voorhees, John J.

doi:10.1111/1523-1747.ep12616668

Cited by 193 publications

(125 citation statements)

References 32 publications

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“…However, studies using PCR have shown an abundance of IGF-I receptor mRNA in human skin biopsies (20), which could suggest an IGF-I-mediated action on skin.…”

Section: Discussionmentioning

confidence: 99%

Skin morphological changes in growth hormone deficiency and acromegaly

Lange

Thulesen

Feldt‐Rasmussen

et al. 2001

European Journal of Endocrinology

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Objective: To evaluate the histomorphology of skin and its appendages, especially eccrine sweat glands, in patients with GH disorders, because reduced sweating ability in patients with growth hormone de®ciency (GHD) is associated with increased risk of hyperthermia under stressed conditions. Design and methods: A skin biopsy was obtained from 17 patients with GHD treated with GH, ®ve patients with untreated GHD, 10 patients with active acromegaly and 13 healthy controls. Results: The sweat secretion rate (SSR) was signi®cantly decreased in both the untreated (median 41 mg/30 min, range 9±79 mg/30 min) and the GH-treated (median 98 mg/30 min, range 28± 147 mg/30 min) patients with GHD compared with that in controls (median 119 mg/30 min, range 90±189 mg/30 min; P 0X001 and 0.01 respectively). Epidermal thickness was signi®cantly decreased in both untreated (median 39 mm, range 28±55 mm) and GH-treated patients with GHD (median 53 mm, range 37±100 mm), compared with that in controls (median 66 mm, range 40± 111 mm; P , 0X02X A statistically non-signi®cant tendency towards thinner epidermis (median 59 mm, range 33±83 mm) was recorded in acromegalic patients P 0X08 compared with controls. There was no signi®cant difference in the area of the sebaceous glands in the biopsies between the three groups and the controls. The area of eccrine sweat gland glomeruli was signi®cantly decreased in the untreated patients with GHD (median 16407 mm 2 , range 12758±43976 mm 2 ) compared with that in controls (median 29446 mm 2 , range 13511±128661 mm 2 ; P 0X03Y but there was no signi®cant difference between the GH-treated patients with GHD and controls. Conclusions: We conclude that GH, either directly or via IGF-I, may have both a structural and a functional effect on human skin and its appendages, and that patients with GHD have histomorphological changes in skin compared with controls. Importantly, these changes are not fully reversed despite long-term and adequate GH treatment in patients with childhood onset GHD.

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“…However, studies using PCR have shown an abundance of IGF-I receptor mRNA in human skin biopsies (20), which could suggest an IGF-I-mediated action on skin.…”

Section: Discussionmentioning

confidence: 99%

Skin morphological changes in growth hormone deficiency and acromegaly

Lange

Thulesen

Feldt‐Rasmussen

et al. 2001

European Journal of Endocrinology

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“…IGF-I is produced primarily by hepatocytes, but also by many other cells including chondrocytes, osteoblasts, epithelial breast cells, granulosa cells, melanocytes and dermal fibroblasts (Adashi et al, 1985;D'Ercole et al, 1984;Han et al, 1987;Tavakkol et al, 1992), where it may act in an autocrine or paracrine manner. Serum levels of IGF-I have been reported to increase from birth to puberty, followed by a slow decline through adulthood.…”

Section: Introductionmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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“…In skin, IGF-1 produced by dermal fibroblasts and macrophages (Han et al, 1987;Rappolee et al, 1988) is thought to signal to basal epidermal keratinocytes that express the IGF-1 receptor (Hodak et al, 1996). In keratinocytes, IGF-1 is thought to stimulate proliferation (Tavakkol et al, 1992) and to contribute to hair follicle morphogenesis (Liu et al, 1993;Philpott et al, 1994;Rudman et al, 1997). Mice with a targeted deletion of the IGF-1 receptor die shortly after birth from respiratory failure and show an abnormally thin and translucent epidermis with a decreased number of hair follicles (Liu et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways

Haase

Evans

Pofahl

et al. 2003

Journal of Cell Science

219

193

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Fig. 8. Effect of toxin B and ML-7 on wound epithelialization in vitro. Mitomycin-C-treated keratinocytes in FAD low Ca 2+ were wounded and incubated for 6 hours in the presence of growth factors. Wounded monolayers were stimulated with 100 ng ml -1 IGF-1 (A,B) or 10 ng ml -1 EGF (C-E) in the presence of 20 ng ml -1 toxin B (B) and 5 µM (D) or 10 µM (E) ML-7 or the respective vehicle controls (A,C).

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Expression of Growth Hormone Receptor, Insulin-Like Growth Factor 1 (IGF-1) and IGF-1 Receptor mRNA and Proteins in Human Skin

Cited by 193 publications

References 32 publications

Skin morphological changes in growth hormone deficiency and acromegaly

Skin morphological changes in growth hormone deficiency and acromegaly

Skin and brain age together: The role of hormones in the ageing process

Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways

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