Expression of heat-shock proteins is associated with major adverse prognostic factors in acute myeloid leukemia

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

“…As such, the chaperonin has become the subject of studies aiming at determining its precise role as etiologic-pathogenic factor and also aiming at inventing new diagnostic and therapeutic ways centered on it. Adrenal gland Adrenal Cushing's tumor [168] Bladder Transitional cell carcinoma; carcinosarcoma [169][170][171] Bone marrow, blood, lymph nodes Acute myeloid leukemia; Hodgkin's lymphoma [155,[172][173][174] Brain Astroglyoma; glioblastoma; meningioma [175][176][177][178][179] Breast Breast ductal carcinoma [180,181] Esophagus Oesophageal carcinoma [182,183] Large bowel Adenocarcinoma [23,169,[184][185][186][187] Liver Hepatocellular carcinoma [188] Lung Bronchial carcinoma [25,26,189,190] Ovary Serous ovarian cancer [191] Prostate Prostate carcinoma [24,[192][193][194] Stomach Gastric maltoma [195] Uterus Exocervical carcinoma [22,196] Adapted from [2]. ATP synthase [197] Dihydrofolatereductase [37,46] Hsp10 [37,41] Human Carbonicanhydrase II [37,198,…”

High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis

“…[5][6][7] Another study also showed that patients with a lower HSP70 expression had higher CR rates as well as a significantly longer median overall survival. 8 The cutoff values we analyzed were not yet evaluated in other studies. Possibly, the amount of HSP70 expression could help to develop treatment strategies for individual patients considering their prognostic risk.…”

Hsp60 Regulation of Tumor Cell Apoptosis

“…However, whether Hsp60 also contributes to cell survival is controversial, with data suggesting a pro-apoptotic function via enhanced caspase activation (13,14) or, conversely, an anti-apoptotic mechanism involving sequestration of Bax-containing complexes (15). A role of Hsp60 in cancer is equally uncertain, as up-regulation (16,17) or down-regulation (18,19) of this chaperone has been reported in various tumor series correlating with disease outcome.…”