Expression of HECA-452 in Parapsoriasis and Mycosis Fungoides

Abstract

We have investigated the HECA-452 expression in large plaque parapsoriasis (PP) and mycosis fungoides (MF) patients, evaluating the potential role of this biomarker in both cutaneous disorders. Skin specimens from 72 PP and 61 MF patients were selected in this study. We compared their actual histological diagnosis with their previous diagnosis and we found that all 72 PP patients had the same diagnosis as before (stable PP), while 26 out of 61 MF have a previous PP histological diagnosis (evolving PP). Our results show an increased expression of HECA-452 in MF compared to PP (p<0.01). Furthermore, evolving PP showed a significantly higher level of HECA-452 than stable PP (p< 0.05). We conclude that HECA-452 expression increases during the natural history of Mycosis Fungoides. HECA-452 could be used as a biomarker for MF and predict which PP evolves to MF.

In Vitro Stem Cell Cultures from Human Dental Pulp and Periodontal Ligament: New Prospects in Dentistry

“…I) (II). The literature is not without data on the characteristics of multipotential stromal cells deriving from bone marrow (BMSCs) and their potential development into osteoblasts, chondrocytes, adipocytes and perhaps even into muscle and neural tissues (12)(13)(14)(15)(16)(17); they are also characterized by their high proliferative capacity ex vivo and differentiation in multiple lines of cells according to the micro-environmental conditions in which they are cultivated. By analogy, it is possible to speculate that tissues taken from DPCs, from exfoliated deciduous teeth (EDCs) and from PDLCs contain a population of multi potential formative cells.…”

Expression and Secretion of CXCL8 (IL-8), Release of Tryptase and Transcription of Histidine Decarboxylase mRNA by Anti-IgE-Activated Human Umbilical Cord Blood-Derived Cultured Mast Cells

“…In addition to acute inflammatory responses, PMN appear to be involved in the pathogenesis of acute and chronic inflammatory disorders [35][36][37] . RANTES and MCP-1 ␤ chemokines are potent chemoattractants for mast cells and have histamine-releasing activity comparable with that of anti-IgE [9][10][38][39][40] . We have previously shown that chemokines (C-C) such as MCP-1 and RANTES induce steady-state levels of histidine decarboxylase (HDC) mRNA in basophilic cells in vitro and in vivo and recruited mast cell mediation of allergic inflammation [9,10] .…”

Prophylactic and Therapeutic EBV Vaccines: Major Scientific Obstacles, Historical Progress, and Future Direction

“…EBV-infected B cells widely express MHC-II molecules and activate CD4+ T cells. EBV-specific CD4+ T cell responses are readily identifiable against soluble lytic antigens (BZLF1, BMLF1, and BCRF1), the envelope components (gp350 and gp110) [56][57][58][59][60], and the potential latent antigens (EBNA 1, 2, 3C, and LMP2) [48]. CD4+ CTLs recognize antigens in EBV lytic/latent phases and kill infected B cells and LCLs through Fas/FasL interactions [61].…”