Expression of hepatocyte growth factor and c-Met in non-small-cell lung cancer and association with lymphangiogenesis

Zhang, Nan; Xie, Fubo; Gao, Wei; Yu, Shuwen; Qiu, Liyun; Lin, Wen-Li; Sun, Yehuan; Jia, Tanghong

doi:10.3892/mmr.2014.3071

Cited by 12 publications

(11 citation statements)

References 43 publications

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“…Additionally, HGF and FGF2 have been shown to be increased during lymphangiogenesis. The findings were correlated with a highly expressed cognate receptor of HGF/c-Met during inflammation and in cancer-associated lymphatic vessels in both in vitro and in vivo studies, suggesting a direct role of HGF with LECs [116][117][118]. Fibroblast growth factor 2 (FGF2) can synergize with VEGF-C signaling and induce lymphatic vessel formation and tumor metastasis [119,120].…”

Section: Genes Involved In Tumor-associated Lymphangiogenesismentioning

confidence: 87%

The Roles of Non-Coding RNAs in Tumor-Associated Lymphangiogenesis

Yusof

Rosli

Abdullah

et al. 2020

Cancers

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Lymphatic vessels are regarded as the ”forgotten” circulation. Despite this, growing evidence has shown significant roles for the lymphatic circulation in normal and pathological conditions in humans, including cancers. The dissemination of tumor cells to other organs is often mediated by lymphatic vessels that serve as a conduit and is often referred to as tumor-associated lymphangiogenesis. Some of the most well-studied lymphangiogenic factors that govern tumor lymphangiogenesis are the vascular endothelial growth factor (VEGF-C/D and VEGFR-2/3), neuroplilin-2 (NRP2), fibroblast growth factor (FGF), and hepatocyte growth factor (HGF), to name a few. However, recent findings have illustrated that non-coding RNAs are significantly involved in regulating gene expression in most biological processes, including lymphangiogenesis. In this review, we focus on the regulation of growth factors and non-coding RNAs (ncRNAs) in the lymphatic development in normal and cancer physiology. Then, we discuss the lymphangiogenic factors that necessitate tumor-associated lymphangiogenesis, with regards to ncRNAs in various types of cancer. Understanding the different roles of ncRNAs in regulating lymphatic vasculature in normal and cancer conditions may pave the way towards the development of ncRNA-based anti-lymphangiogenic therapy.

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Section: Genes Involved In Tumor-associated Lymphangiogenesismentioning

confidence: 87%

The Roles of Non-Coding RNAs in Tumor-Associated Lymphangiogenesis

Yusof

Rosli

Abdullah

et al. 2020

Cancers

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“…In the network enrichment analysis, c‐MET has been identified as a hub which plays key roles in cancer initiation and progression of cigarette smoking‐associated NSCLC (Pazhouhandeh et al ., ). Activation of the HGF/c‐MET signaling pathway has also been found to be associated with a poor prognosis in various solid tumors including NSCLC (Guo et al ., ; Zhang et al ., ), indicating a predictive value for this disease. The critical role of crosstalk between the c‐MET and ErbB family in the development of resistance to cancer therapeutics has been well elucidated (Lai et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoke enhances oncogene addiction to c‐MET and desensitizes EGFR‐expressing non‐small cell lung cancer to EGFR TKIs

Cheng

Chen

et al. 2018

Molecular Oncology

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Cigarette smoking is one of the leading risks for lung cancer and is associated with the insensitivity of non‐small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, it remains undetermined whether and how cigarette smoke affects the therapeutic efficacy of EGFR TKIs. In this study, our data showed that chronic exposure to cigarette smoke extract (CSE) or tobacco smoke‐derived carcinogen benzo[α]pyrene, B[α]P, but not nicotine‐derived nitrosamine ketone (NNK), reduced the sensitivity of wild‐type EGFR‐expressing NSCLC cells to EGFR TKIs. Treatment with TKIs almost abolished EGFR tyrosine kinase activity but did not show an inhibitory effect on downstream Akt and ERK pathways in B[α]P‐treated NSCLC cells. CSE and B[α]P transcriptionally upregulate c‐MET and activate its downstream Akt pathway, which is not inhibited by EGFR TKIs. Silencing of c‐MET reduces B[α]P‐induced Akt activation. The CSE‐treated NSCLC cells are sensitive to the c‐MET inhibitor crizotinib. These findings suggest that cigarette smoke augments oncogene addiction to c‐MET in NSCLC cells and that MET inhibitors may show clinical benefits for lung cancer patients with a smoking history.

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“…Other growth factors with pro-lymphangiogenic activity have been identified through cancer research. These include HGF [ 35 , 36 , 37 ], PDGF [ 37 , 38 , 39 ], IGF [ 40 , 41 ], and endothelin-1 [ 42 , 43 ]. TGF-β has also reportedly regulated lymphatic vessel sprouting during development [ 44 , 45 ].…”

Section: Cytokines and Molecular Markers For Lymphangiogenesismentioning

confidence: 99%

Corneal Lymphangiogenesis: Current Pathophysiological Understandings and Its Functional Role in Ocular Surface Disease

Lee

2021

IJMS

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The cornea is a transparent and avascular tissue that plays a central role in light refraction and provides a physical barrier to the external environment. Corneal avascularity is a unique histological feature that distinguishes it from the other parts of the body. Functionally, corneal immune privilege critically relies on corneal avascularity. Corneal lymphangiogenesis is now recognized as a general pathological feature in many pathologies, including dry eye disease (DED), corneal allograft rejection, ocular allergy, bacterial and viral keratitis, and transient corneal edema. Currently, sizable data from clinical and basic research have accumulated on the pathogenesis and functional role of ocular lymphangiogenesis. However, because of the invisibility of lymphatic vessels, ocular lymphangiogenesis has not been studied as much as hemangiogenesis. We reviewed the basic mechanisms of lymphangiogenesis and summarized recent advances in the pathogenesis of ocular lymphangiogenesis, focusing on corneal allograft rejection and DED. In addition, we discuss future directions for lymphangiogenesis research.

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Expression of hepatocyte growth factor and c-Met in non-small-cell lung cancer and association with lymphangiogenesis

Cited by 12 publications

References 43 publications

The Roles of Non-Coding RNAs in Tumor-Associated Lymphangiogenesis

The Roles of Non-Coding RNAs in Tumor-Associated Lymphangiogenesis

Cigarette smoke enhances oncogene addiction to c‐MET and desensitizes EGFR‐expressing non‐small cell lung cancer to EGFR TKIs

Corneal Lymphangiogenesis: Current Pathophysiological Understandings and Its Functional Role in Ocular Surface Disease

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