Abstract:Polymerase n (PolN) is a poorly understood error‐prone polymerase that is involved in DNA repair pathways. PolN‐deficient cells are more sensitive to interstrand cross‐links (ICL) agents, suggesting that PolN is involved in repairing ICL. PolN has also been linked to cancer, including amplification in neuroendocrine prostate cancers, but its role is unknown. One of the challenges that hinders PolN studies is the poor heterologous expression of PolN. Here we seek to systematically improve the expression and pur… Show more
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