Expression of HMGA1 and Ezrin in laryngeal squamous cell carcinoma

Wang, Desheng; Pan, Chensheng; Lai, Haichun; Huang, Jianmin

doi:10.3109/00016489.2012.758388

Cited by 9 publications

(9 citation statements)

References 13 publications

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“…Similar to Wang et al report, HMGA1 expression also correlated with tumor size, tumor invasion, and histological grade in human pituitary adenomas [26]. In laryngeal squamous cell carcinoma, HMGA1 overexpression positively associated with clinical stage, lymph node metastasis, and histological grade [27]. These studies consistently suggest that overexpressed HMGA1 may play an unfavorable role in breast cancer patients.…”

Section: Discussionsupporting

confidence: 56%

Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer

Huang

Dai

et al. 2015

Mol Cell Biochem

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High mobility group A1 (HMGA1), as a major member of HMGA family, plays an important part in promotion of cell proliferation and motility, induction of epithelial-mesenchymal transition, and maintenance of stemness, but little is known about the pathological role of HMGA1 in breast cancer patients. The aim of this study was to identify the pathological roles of HMGA1 in breast cancer. In our results, we found that mRNA and protein expression levels of HMGA1 were markedly higher in breast cancer tissues than in normal breast tissues. Using immunohistochemistry, high levels of HMGA1 protein were positively correlated with the status of histological grade (I-II vs. III-IV; P = 0.023), clinical stage (I-II vs. III-IV; P = 0.008), tumor size (T1-T2 vs. T3-T4; P = 0.015), lymph node metastasis (N0-N1 vs. N2-N3; P = 0.002), distant metastasis (M0 vs. M1; P < 0.001), and triple-negative breast cancer (No vs. Yes; P = 0.014) of breast cancer patients. Patients with higher HMGA1 expression had a significantly shorter overall survival time than did patients with low HMGA1 expression. Multivariate analysis indicated that the level of HMGA1 expression was an independent prognostic indicator (P < 0.001) for the survival of patients with breast cancer. In conclusion, HMGA1 plays an important role on breast cancer aggressiveness and prognosis and may act as a promising target for prognostic prediction.

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Section: Discussionsupporting

confidence: 56%

Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer

Huang

Dai

et al. 2015

Mol Cell Biochem

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“…Our results may indicate that HMGA1 plays significant roles in NSCLC progression, including tumor proliferation, invasion, and metastasis. Similar to Wang et al's report, HMGA1 overexpression positively associated with clinical stage, lymph node metastasis, and histological grade in patients with laryngeal squamous cell carcinoma [29]. In human pituitary adenomas, HMGA1 expression also correlated with tumor size, tumor invasion, and histological grade [19].…”

Section: Discussionmentioning

confidence: 59%

Elevated expression of HMGA1 correlates with the malignant status and prognosis of non-small cell lung cancer

et al. 2014

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High-mobility group A1 (HMGA1) has been suggested to play a significant role in tumor progression, but little is known about the accurate significance of HMGA1 in non-small cell lung cancer (NSCLC) patients. The aim of this study was to identify the role of HMGA1 in NSCLC. The expression status of HMGA1 was observed initially in NSCLC by Gene Expression Omnibus (GEO). The expression of HMGA1 messenger RNA (mRNA) and protein was examined in NSCLC and adjacent normal lung tissues through real-time PCR and immunohistochemistry. Meanwhile, the relationship of HMGA1 expression levels with clinical features and prognosis of NSCLC patients was analyzed. In our results, HMGA1 was overexpressed in NSCLC tissues compared with adjacent normal lung tissues in microarray data (GSE19804). HMGA1 mRNA and protein expressions were markedly higher in NSCLC tissues than in normal lung tissues (P < 0.001 and P = 0.010, respectively). Using immunohistochemistry, high levels of HMGA1 protein were positively correlated with the status of clinical stage (I-II vs. III-IV, P < 0.001), T classification (T1-T vs. T3-T4, P = 0.003), N classification (N0N1 vs. N2-N3, P < 0.001), M classification (M0 vs. M1, P = 0.002), and differentiated degree (high or middle vs. low or undifferentiated, P = 0.003) in NSCLC. Patients with higher HMGA1 expression had a significantly shorter overall survival time than did patients with low HMGA1 expression. Multivariate analysis indicated that the level of HMGA1 expression was an independent prognostic factor (P < 0.001) for the survival of patients with NSCLC. In conclusion, HMGA1 plays an important role on NSCLC progression and prognosis and may act as a convictive biomarker for prognostic prediction.

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“…This transformation may weaken intercellular adhesion of normal cells and enhance the adhesion between tumor cells and normal cells, which promote tumor metastasis. [ 15 ] According to the author Zhai et al ., the activation of Rac 1 pathway by ezrin causes hepatocyte growth factor to induce tyrosine phosphorylation of E-catenin and X-catenin, inhibits the function of E-cadherin, and leads to redistribution of E cadherin in cytoplasm and on cell membrane. [ 16 ]…”

Section: Discussionmentioning

confidence: 99%

“…Phosphorylation of ezrin at its tyrosine residues activates the PI3-kinase/Akt pathway, thereby prevents apoptosis of tumor cells. [ 15 ] Schlecht et al . observed that high cytoplasmic ezrin expression indicates the altered expression of antiapoptotic genes (BIRC2, CCDC50, and TGM2) and proapoptotic genes (EDARADD), resulting in survival rather than cell death.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of ezrin in oral potentially malignant disorders-A descriptive study

et al. 2017

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Introduction:Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell–cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Recent analysis reveals their involvement in signaling pathways. Ezrin is highly expressed in several types of human cancers, and correlation between its immunoreactivity and histopathological data as well as the patient outcome has previously been studied.Objective:The objective of the study was to analyze the immunohistochemical expression pattern of ezrin in oral potentially malignant disorders (OPMDs), namely, oral submucous fibrosis (OSMF) with different grades and clinically leucoplakia (hyperkeratosis with various degree of dysplasia) and its use as a predictive marker for malignant transformation.Subjects and Methods:Sample size n = 43, histopathologically confirmed cases of OPMDs (13 cases of OSMF with different grades and 30 cases of clinically leukoplakia) were retrieved from the Department of Oral and Maxillofacial Pathology. Immunohistochemistry was done using anti-ezrin antibody, and the expression was graded in terms of proportion and intensity.Results:There was a significant expression of ezrin in OPMDs, and its cytoplasmic shift can be used as a predictive marker for malignant transformation.Conclusion:The findings of the current study revealed that the expression of ezrin in OPMDs may be related to the progression of the disease.

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Expression of HMGA1 and Ezrin in laryngeal squamous cell carcinoma

Cited by 9 publications

References 13 publications

Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer

Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer

Elevated expression of HMGA1 correlates with the malignant status and prognosis of non-small cell lung cancer

Immunohistochemical expression of ezrin in oral potentially malignant disorders-A descriptive study

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