Expression of HPIP in epithelial ovarian carcinoma: a clinicopathological study

Abstract

ObjectivesHematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP) plays an important role in cancer invasion and metastasis. The aim of this study is to investigate the expression of HPIP in epithelial ovarian cancer (EOC).Patients and methodsImmunohistochemical method was performed using 42 normal ovarian specimens and 145 specimens with EOC. The correlations of HPIP expression with the clinicopathological factors and prognosis of EOC patients were evaluated. Statistical analyses were performed using the chi-square test, multivariate Cox proportional hazard, and Kaplan–Meier method.ResultsHPIP expression in EOC was higher than that in normal tissues (P<0.001). HPIP expression was significantly associated with histological grade, International Federation of Gynecology and Obstetrics stage, and lymphatic metastasis of EOC (P<0.05). Patients with high HPIP expression had poorer overall survival and disease-free survival (P<0.001) compared with patients with low HPIP expression. Multivariate Cox analysis demonstrated that HPIP was an independent factor for overall survival and disease-free survival (P<0.05).ConclusionHPIP may be a valuable biomarker for predicting the prognosis of EOC patients and may serve as a potential target for cancer therapy.

HPIP: a predictor of lymph node metastasis and poor survival in cervical cancer

“…Our results are consistent with the previous findings on the roles of HPIP in tumor progression in various cancers, including renal cell carcinoma, 20 breast cancer, 4 colorectal cancer, 12 and ovarian cancer. 14 All these findings suggest an important tumor biological role of HPIP in carcinogenesis and tumor progression.…”

“…These results are consistent with the results from previous studies. 11 , 14 However, there are no significant relationships of HPIP expression either with differentiation or with lymph node metastasis in oral squamous cell carcinoma. 8 In addition, HPIP expression is correlated with lymph node metastasis instead of differentiation in gastric cancer.…”

“…HPIP, a nucleocytoplasmic shuttling protein, 4 was originally isolated based on a yeast two-hybrid screen using a human hematopoietic cDNA-based library. 5 HPIP has been reported to be upregulated in human cancers, 4 , 6 – 14 and several studies suggest that the abnormal expression of HPIP plays an important role in tumor cancer proliferation, cell cycle, adhesion, migration, metastasis, and apoptosis. 4 , 7 – 9 , 12 , 13 , 15 – 17 However, the significance of HPIP expression in CC in terms of survival status has not been examined.…”

Overexpression of HPIP as a biomarker for metastasis and prognosis prediction in endometrial cancer patients

“…[4][5][6][7][8][9][10][11][12][13][14][15] However, by reviewing the literature, we have not found a report on the expression of HPIP in endometrial cancer. According to the currently reported studies, HPIP exhibited an excessive expression status in numerous cancer tissues, while HPIP expression is involved in various aspects of cancer progression and predicts poor prognosis in cancer patients.…”

“…According to the currently reported studies, HPIP exhibited an excessive expression status in numerous cancer tissues, while HPIP expression is involved in various aspects of cancer progression and predicts poor prognosis in cancer patients. [4][5][6][7][8][9][10][11][12][13][14][15] However, by reviewing the literature, we have not found a report on the expression of HPIP in endometrial cancer.…”