Expression of HSP70 in Human Skin After Cryolipolysis Treatment

Stevens, W. Grant; Pérez, José Alberto Hermida; Pham, Linda D.; Lozano, Joel N Jimenez

doi:10.1093/asj/sjad178

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…If their study did not focus on preventing ice nucleation in supercooling temperatures, it highlights again the critical role of the CPA in ensuring cell homeostasis during subzero storage. Finally, Stevens et al ( 61 ) proved that supercooled skin during cryolipolysis treatment induced Heat Shock Protein 70 expression, which is known as a thermal stress protector transcription factor.…”

Section: Supercooling Principles To Extend Organ Preservationmentioning

confidence: 99%

Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts

Berkane,

Hayau,

Filz von Reiterdank

et al. 2023

Front. Transplant.

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Ex vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in favor of substantially improved outcomes. It is based on decreasing ischemia-reperfusion phenomena by providing physiological or sub-physiological conditions until transplantation. Alternatively, supercooling techniques involving static preservation at negative temperatures while avoiding ice formation have shown encouraging results in solid organs. Here, the rationale is to decrease the organ's metabolism and need for oxygen and nutrients, allowing for extended preservation durations. The aim of this work is to review all advances of supercooling in transplantation, browsing the literature for each organ. A specific objective was also to study the initial evidence, the prospects, and potential applications of supercooling preservation in Vascularized Composite Allotransplantation (VCA). This complex entity needs a substantial effort to improve long-term outcomes, marked by chronic rejection. Improving preservation techniques is critical to ensure the favorable evolution of VCAs, and supercooling techniques could greatly participate in these advances.

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Section: Supercooling Principles To Extend Organ Preservationmentioning

confidence: 99%

Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts

Berkane,

Hayau,

Filz von Reiterdank

et al. 2023

Front. Transplant.

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“…As adenocarcinoma of the distal esophagus and gastroesophageal junction (squamous cell carcinomas or adenomas) account for more than 90% of esophageal neoplasm, their prevalence is on the rise [ 1 ], Tobacco Smoking is linked to an increase in the occurrence of esophageal cancer [ 2 , 3 ]. A minimum of 50% of patients exhibit metastatic cancer, and the majority of patients with localized illness will eventually acquire metastases.…”

Section: Introductionmentioning

confidence: 99%

The Cytotoxic Effect of Ciprofloxacin Laetrile Combination on Esophageal Cancer Cell Line

Jumaa,

Abdulkareem,

Yasin

2024

Asian Pac J Cancer Prev

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Objective: aim of this study was to examine the synergistic effect between the antibacterial drug ciprofloxacin and the natural compound laetrile on esophageal cancer cells, specifically focusing on their combined cytotoxic effect. Methods: The combined cytotoxic effects of two alternative incubation durations (24 and 72 hours) were studied using an esophageal cancer cell line. Ciprofloxacin, laetrile, and their combinations were tested at concentrations ranging from 1 to 1000 micrograms/milliliter, to enhance the safety of the combination, the concentrations of the combination constituents were reduced by half compared to when they are used individually, the combination index was then calculated to estimate the components’ possible synergistic effects. Result: The results indicate that the combined cytotoxicity of ciprofloxacin and laetrile was greater than the cytotoxicity of either ciprofloxacin or laetrile alone, the combination cytotoxicity increased with higher concentrations and longer incubation periods, in other words, the cytotoxicity pattern of the combination was time-dependent (cell-cycle specific), and concentration dependent, (cell-cycle non-specific). Conclusion: The study found that the combination of ciprofloxacin and laetrile had a greater inhibitory effect on the growth of esophageal cancer cells compared to ciprofloxacin or laetrile alone. This suggests a synergistic effect between the components of the mixture, which can be attributed to a complementary mechanism between the ingredients in the combination.

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Commentary on: Expression of HSP70 in Human Skin After Cryolipolysis Treatment

Durán-Vega

Krötzsch

2023

Aesthetic Surgery Journal

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Expression of HSP70 in Human Skin After Cryolipolysis Treatment

Cited by 3 publications

References 16 publications

Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts

Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts

The Cytotoxic Effect of Ciprofloxacin Laetrile Combination on Esophageal Cancer Cell Line

Commentary on: Expression of HSP70 in Human Skin After Cryolipolysis Treatment

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