Expression of human leukocyte antigen-G in systemic lupus erythematosus

Human leukocyte antigen–G is upregulated in heart failure patients: A potential novel biomarker

“…The immunosuppressive role of HLA-G is apparent by its ability to inhibit CD8-T cell toxicity [22], CD4-T cell alloreactivity [23], and natural killer cell-mediated cytolysis [13], and activate regulatory CD4 Ϫ T cells [24]. Numerous studies have shown the relevance of HLA-G in several inflammatory and autoimmune diseases, such as systemic lupus erythematosis (SLE) [19]. HLA-G was found to be markedly elevated during septic shock, with a possible role in negative feedback signals that limit the process of inflammation [20].…”

“…It is upregulated in response to transplantation [14,15], malignancies [16,17] and inflammation [18,19], and has also been correlated with various clinical outcomes. This molecule has potent immunoregulatory effects that are directed at different elements of the immune system.…”

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

“…Under pathological conditions, tumors (Urosevic and Dummer, 2003) and tissues affected by autoimmune diseases (Rosado et al, 2008) and viral infections (Lozano et al, 2002) may express HLA-G.…”

Role of HLA-G and other immune mechanisms in pregnancy

“…HLA-G has also been detected in adult tissues, such the thymic medulla [45], cornea, pancreas [46] or in human mononuclear phagocytes [47]. In addition, its expression can be induced under pathological conditions following transplantation [48][49][50], tumors [51,52], viral infections [53] and autoimmune diseases [54,55]. The immunosuppression seems to be beneficial in transplantation and autoimmune diseases, whereas it is detrimental in the case of tumors or viral infections.…”