Expression of hypothalamic neuropeptides and the desensitization of pituitary–adrenal axis and hypophagia in the endotoxin tolerance

Borges, Beatriz de Carvalho; Antunes‐Rodrigues, José; Castro, Margaret de; Bittencourt, Jackson C.; Elias, Carol F.; Elias, Lucila Leico Kagohara

doi:10.1016/j.yhbeh.2007.07.006

Cited by 35 publications

(36 citation statements)

References 67 publications

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“…This result agrees with previous reports using different experimental models (30,31) that also showed a differential expression of CART and POMC mRNAs, suggesting a distinct intracellular regulation of these neuropeptides.…”

Section: Discussionsupporting

confidence: 93%

Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides

Silva

Castro

Amaral

et al. 2010

Braz J Med Biol Res

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Section: Discussionsupporting

confidence: 93%

Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides

Silva

Castro

Amaral

et al. 2010

Braz J Med Biol Res

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“…Food control mechanisms are controlled by the hypothalamus function through the integration of multiple sensory signals that activate or deactivate food search behaviors. Behaviors related to feelings of hunger or satiety are driven by the action of hormones and neurotransmitters 9 .…”

Section: Introductionmentioning

confidence: 99%

Acute hypothalamic administration of L-arginine increases feed intake in rats

et al. 2015

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ObjectiveThis study investigated the chronic (oral) and acute (hypothalamic infusion) effects of L-arginine supplementation on feed intake, body composition, and behavioral changes in rats. MethodsTwenty rats were divided into two groups treated orally for 60 days; one group received L-arginine (1 g/kg body weight) and one group received saline (1 mL/NaCl 0.9%). Daily consumption of water and food were evaluated, and weight monitored. After the oral treatment, the rats underwent stereotactic biopsy and a group was injected with 2 µL of L-arginine (0.5 mM) and another received an injection of saline (0.9% NaCl), in the hypothalamic route, through micro infusion. Immediately after micro infusion, the animal behavior was evaluated through tests in the open field. Food and water consumption were evaluated at 12 and 24 hours after the micro infusion. Daily water consumption and weight gain evolution were evaluated. At the end of treatments, rats were euthanized and blood was collected for glucose, glycerol, and cholesterol evaluation, and histological analysis of vital organs. ResultsOral supplementation with L-arginine increased water intake (11%, p<0.05) and promoted weight gain (3%, p<0.05). However, hypothalamic infusion promoted a significant increase in chow intake (30%, p<0.05) after 24 hours of L-arginine administration.

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“…One of every third section was mounted and used for probe hybridization. The respective [ 35 S] riboprobes were generated as described previously and kindly provided by Dr. Jackson Cioni Bittencourt ' s lab: CART (Douglass et al , 1995 ;Elias et al , 2000 ;Borges et al , 2007 ) and NPY (Higuchi et al , 1988 ;Borges et al , 2007 ). Briefl y, the probes were in vitro transcribed with the appropriate RNA polymerases (either T3 or SP6) according to the producer ' s protocol (Promega).…”

Section: In Situ Hybridizationmentioning

confidence: 99%

Kinin B1 receptor gene ablation affects hypothalamic CART production^b

Torres¹,

Motta²,

Sales³

et al. 2013

Biological Chemistry

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Abstract:A role for the kinin B1 receptor in energy-homeostatic processes was implicated in previous studies; notably, the studies where kinin B1 receptor knockout mice (B1 -/-) were shown to have impaired adiposity, impaired leptin and insulin production, lower feed efficiency, protection from liver steatosis and diet-induced obesity when fed a high fat diet (HFD). In particular, in a model where the B1 receptor is expressed exclusively in the adipose tissue, it rescues the plasma insulin concentration and the weight gain seen in wild type mice. Taking into consideration that leptin participates in the formation of hypothalamic nuclei, which modulate energy expenditure, and feeding behavior, we hypothesized that these brain regions could also be altered in B1 -/-mice. We observed for the first time a difference in the gene expression pattern of cocaine and amphetamine related transcript (CART) in the (lateral hypothalamic area (LHA) resulting from the deletion of the kinin B1 receptor gene. The correlation between CART expression in the LHA and the thwarting of diet-induced obesity corroborates independent correlations between CART and obesity. Furthermore, it seems to indicate that the mechanism underlying the ' lean ' phenotype of B1 -/-mice does not stem solely from changes in peripheral tissues but may also receive contributions from changes in the hypothalamic machinery involved in energy homeostasis processes.

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Expression of hypothalamic neuropeptides and the desensitization of pituitary–adrenal axis and hypophagia in the endotoxin tolerance

Cited by 35 publications

References 67 publications

Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides

Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides

Acute hypothalamic administration of L-arginine increases feed intake in rats

Kinin B1 receptor gene ablation affects hypothalamic CART production^b

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Expression of hypothalamic neuropeptides and the desensitization of pituitary–adrenal axis and hypophagia in the endotoxin tolerance

Cited by 35 publications

References 67 publications

Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides

Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides

Acute hypothalamic administration of L-arginine increases feed intake in rats

Kinin B1 receptor gene ablation affects hypothalamic CART productionb

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Kinin B1 receptor gene ablation affects hypothalamic CART production^b