Expression ofMYD88in Adipose Tissue of Obese People: Is There Some Role in the Development of Metabolic Syndrome?

Abstract

Background: The mechanism leading to the development of metabolic complications in obese individuals is not fully understood. Thus, the objective of this study was to examine differences in insulin resistance, inflammation, cytokine and adipokine levels, and expression of selected genes across obese individuals with different number of metabolic syndrome (MetS) components. Methods: Forty obese individuals who underwent bariatric surgery, divided in three groups based on the number of components of MetS, in addition to abdominal obesity (0, 1, and 2-3 additional components), were studied. Levels of inflammatory proteins, insulin resistance, cytokines, adipokines, and gene expression in subcutaneous (SAT) and visceral adipose tissue (VAT) were compared. Results: There was a significantly higher expression of MYD88 in SAT among those with more components of MetS (P = 0.008). In SAT, but not in VAT, MYD88 expression was significantly correlated with toll-like receptor 4 expression (r = 0.7, P < 0.05). Expression of adipsin in SAT was also associated with the presence of more components of MetS, but with borderline statistical significance (P = 0.05). There were no significant differences in insulin resistance, inflammation, and cytokine and adipokine levels by the number of components of MetS. Conclusions: Our study suggests that MYD88 expression in SAT of obese subjects could be associated with the development of components of MetS.

Algal Polysaccharides as Therapeutic Agents for Atherosclerosis

“…While dectin-1 knockout in the bone marrow of LDLR −/− mice did not alter the progression of atherosclerosis ( 68 ), a recent study found that dectin-1 signaling enhanced obesity and insulin resistance in mice with in MyD88 knockout mice fed a high fat diet ( 69 ). In humans, expression of MyD88 has been associated with obesity and metabolic syndrome ( 70 ). Dietary supplementation with laminarin-reduced hepatotoxicity in rats treated with lipopolysaccharide (LPS), suggesting an anti-inflammatory effect for some formulations of laminarin ( 71 ).…”

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“…This interaction activates a family of kinases which in turn activate different molecules including NFκB, a primary transcription factor. The translocation of NFκB to the nucleus upregulates the production of INF and inflammatory cytokines, which is an evidence that these receptors play a role in the immune system [53,54].…”

Effect of Basketball on Improving the Health of Obese People under the Monitoring of Internet of Things Technology

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