Expression of SOX2OT, DANCR and TINCR long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features

Abstract

long non-coding rnas (lncrnas) are molecules that are >200 base pairs long and do not encode a protein. However, they perform important roles in regulating gene expression. recent studies have revealed that the changes in the expressions of lncrnas serve a role in the development and metastases of a number of types of cancer. a number of studies have been published on the association of SoX2 overlapping transcript (SOX2OT), differentiation antagonizing non-protein coding rna (DANCR) and tissue differentiation-induced non-coding rna (TINCR) expression with various types of cancer. However, researchers have not yet studied their roles in papillary thyroid cancer or at least, those roles are not clarified. The aim of the present study was to investigate the expression and clinical significance of SOX2OT, DANCR and TINCR in papillary thyroid cancer (PTc). a total of 102 patients with PTc were included in the present study. reverse transcription-quantitative Pcr method was used to determine the relative gene expression levels of lncrnas and then the relationship between expressions of lncrnas and clinical characteristics of the subjects was analyzed in detail. expression levels of SOX2OT (P=0.016) and DANCR (P=0.017) increased in the tumor samples in contrast to the normal tissues. No significant difference was observed in the expression level of TINCR (P=0.298). in addition, SOX2OT expression was associated with micro carcinoma (P<0.001), tumor size (P=0.010) and primary tumor (P=0.006), while DANCR expression was associated with age (P=0.030) and micro carcinoma (P=0.004). The findings of the present study indicated that DANCR may contribute to the development of PTc while SOX2OT may contribute to both the development and progression of PTc.FadiMe MuTlu icduYGu 1 , eGeMen aKGun 2 , deMeT SenGul 3 , aSuMan oZGoZ 4 and eBru alP 2 departments of 1 Medical Genetics,

FDG uptake reflects an immune‐enriched subtype of thyroid cancer: Clinical implications of imaging‐based molecular characterization

“…Direct matching FDG PET/CT results with scRNA‐seq data would provide supports for a correlation between glucose uptake and transcriptomic change in PTC. Moreover, expanding the transcriptomic analysis from the coding RNA to other components such as non‐coding RNA would help to comprehensively understand the metabolic profile of thyroid cancer since long non‐coding RNA has been known to influence the clinicopathologic features in PTC 42 . Another limitation was that the amount of F‐18 FDG PET/CT data was small.…”

“…Moreover, expanding the transcriptomic analysis from the coding RNA to other components such as non‐coding RNA would help to comprehensively understand the metabolic profile of thyroid cancer since long non‐coding RNA has been known to influence the clinicopathologic features in PTC. 42 Another limitation was that the amount of F‐18 FDG PET/CT data was small. Patients were not evenly enrolled in our study.…”

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

“…There are some studies on the number of LncRNA gene polymorphisms associated with various tumors and abnormal expression in many human cancers that have revealed no significant link between their polymorphism and the likelihood of recurrent miscarriage, such as TINCR gene rs2288947 (Y. Liu et al, 2018 (Xu et al, 2023) (Icduygu et al, 2022)(W. , and TOX3 gene that is linked with numerous disorders such as cancer of the pulmonary system, ovarian cancer, breast cancer and polystatic ovarian syndrome (Latif et al, 2010)(W. M. Cao et al, 2016)(X. Zhang et al, 2013)(Gao et al, 2018)(L. Chen et al, 2017 (Bruni et al, 2022).…”

Long Non-Coding RNAs as Determinants of Thyroid Cancer Phenotypes: Investigating Differential Gene Expression Patterns and Novel Biomarker Discovery

“…E-cadherin and N-cadherin are cell adhesion molecules that also serve as markers of EMT. During EMT, a transforming cell will lose its epithelial-like phenotype and downregulate E-cadherin and gain a mesenchymal-like phenotype and upregulate N-cadherin [83]. Thus, a loss in E-cadherin expression can drive EMT processes and significantly contribute to metastatic spread [81].…”

“…The expression of lncRNAs SOX2OT (SOX2 overlapping transcript), DANCR (differentiation antagonizing non-coding RNA), and TINCR (tissue differentiation-induced non-coding RNA) were reported to serve as biomarkers in PTC, due to their association with various clinicopathological features. Upregulation of DANCR and SOX2OT in PTC was observed to correlate with cancer onset, and cancer onset and progression, respectively [83]. Further, the role of DANCR in PTC is poorly studied [84].…”