Expression of IL-1β Receptor Antagonist in Patients with Severe Osteoarthritis of the Knee–The Mechanism Limiting the Inflammation in Osteoarthritis

Pierzchała, Adam

doi:10.4172/2329-8731.1000217

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Role Of Cytokines In Oa1

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2020

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“…IL-1β-mediated catabolism is considered as the key pathophysiological process in the course of OA [ 15 ]. An important mechanism in the OA pathogenesis is IL-1β-induced upregulation of matrix metalloproteinases (MMPs), the group of enzymes involved in the degradation of collagen and other proteins in the ECM.…”

Section: Role Of Cytokines In Oamentioning

confidence: 99%

An insight into osteoarthritis susceptibility: Integration of immunological and genetic background

Štefik

Vranic

Ivkovic

et al. 2020

Bosn J of Basic Med Sci

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Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic mechanisms will enable an insight into OA pathophysiology and lead to novel and integrative approaches in the treatment of OA patients, together with a reduction of the disease risk, or a delay of its onset in susceptible patients.

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Section: Role Of Cytokines In Oamentioning

confidence: 99%