Expression of IL-27, Th1 and Th17 in Patients with Aplastic Anemia

Du, Hui-zhen; Wang, Qian; Ji, Jian; Shen, Baoming; Wei, Shao-chun; Liu, Lijuan; Ding, Juan; Ma, Daoxin; Wen, Wang; Peng, Jun; Hou, Mingxiao

doi:10.1007/s10875-012-9810-0

Cited by 21 publications

(21 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies reported that CD4 + Th17‐cells immune responses play an important role in the pathogenesis of AA. The increased expressions of IL‐17 mRNA and intracellular IL‐17 in BM and PB mononuclear cells have been observed in patients with AA . Although Feng et al.…”

Section: Discussionmentioning

confidence: 99%

“…The increased expressions of IL-17 mRNA and intracellular IL-17 in BM and PB mononuclear cells have been observed in patients with AA. [15][16][17] Although Feng et al measured 31 plasma cytokines using an immunobead-based multiplex assay in patients with AA and MDS, the level of IL-17 was undetectable. [4] Conversely, using a human ELISA kit, Gu et al demonstrated elevated IL-17 levels in BM and PB plasma of patients with AA.…”

Section: Discussionmentioning

confidence: 99%

“…IL‐17, a proinflammatory cytokine that is primarily secreted by CD4 + T helper type 17 cells (Th17 cells), links innate and adaptive immunity and has been shown to play an important role in several autoimmune diseases . An increase in IL‐17‐producing Th17 cells in the peripheral blood and BM of patients with AA has also been reported …”

Section: Introductionmentioning

confidence: 99%

“…[8,14] An increase in IL-17-producing Th17 cells in the peripheral blood and BM of patients with AA has also been reported. [3,[15][16][17] Although a few studies have compared the cytokine profiles of AA and MDS in adults, [4,18] no studies have been published in the pediatric field. Therefore, the aim of this study was to measure the cytokine levels and evaluate whether the plasma levels of TPO and IL-17 can be used to distinguish between AA and hypocellular RCC in children.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Cytokine‐Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood

Elmahdi

Hama

Manabe

et al. 2015

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Cytokine‐Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood

Elmahdi

Hama

Manabe

et al. 2015

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Multiple reports have shown basal levels of circulating IL-27p28 in humans; these levels are altered in many disease states, including bacterial infections, sepsis, aplastic anemia, and ankylosing spondylitis (167)(168)(169)(170)(171). The interpretation of what the changes in levels of IL-27 mean is not straightforward; increased production could indicate causality or simply be a secondary host response to ongoing disease.…”

Section: Translational Implications Of Il-27mentioning

confidence: 99%

The Immunobiology of Interleukin-27

Yoshida

Hunter

2015

Annu. Rev. Immunol.

373

433

View full text Add to dashboard Cite

Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4(+) and CD8(+) T cell effector functions, to induce IL-10, and to promote specialized T regulatory cell responses. Although this aspect of IL-27 biology has provided insights into how the immune system prevents hyperactivity in the setting of infectious and autoimmune inflammation, in vaccination and cancer models the stimulatory effects of IL-27 on CD8(+) T cell function appear prominent. Additionally, associations between IL-27 and antibody-mediated disease have led to an interest in defining the impact of IL-27 on innate immunity and humoral responses in different disease states. The maturation of this literature has been accompanied by attempts to translate these findings from experimental models into human diseases and by efforts to define where IL-27 might represent a viable therapeutic target.

show abstract

Enhanced recruitment and hematopoietic reconstitution of bone marrow‐derived mesenchymal stem cells in bone marrow failure by the SDF‐1/CXCR4

Chen

et al. 2020

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Aplastic anemia (AA) is a bone marrow failure disease. It is difficult to treat AA, and in addition, relapses are common because of its complex disease pathogenesis. Allogeneic bone marrow‐derived mesenchymal stem cells (BMSCs) infusion is an effective and safe treatment option for the AA patients. However, it found that BMSCs infusion in AA patients is less than 30% effective. Therefore, the key to improve the efficacy of BMSCs treatment in these patients is to enhance their homing efficiency to the target sites. Studies have shown that stromal cell‐derived factor‐1 (SDF‐1)/CXC chemokine receptor 4 (CXCR4) axis plays an important role in promoting BMSCs homing. In this study, human BMSCs were transduced with lentivirus stably expressing CXCR4‐BMSCs. Transduced BMSCs resemble normal BMSCs in many ways. Migration ability of CXCR4‐BMSCs toward SDF‐1 was increased because of the overexpression of CXCR4. In the mice with bone marrow failure, the migration and colonization ability of CXCR4‐BMSCs to the bone marrow was significantly improved as seen by IVIS imaging and FACS. The SDF‐1 level in the bone marrow failure mice was significantly higher than in the normal mice. Thus, from our study, it is clear that after CXCR4‐BMSCs were infused into mice with bone marrow failure, SDF‐1 interacted with CXCR4 receptor, leading cells to migrate and colonize to bone marrow. Because of the high SDF‐1 expression in mouse bone marrow and CXCR4 receptor expression in cells, BMSCs homing was increased.

show abstract

Expression of IL-27, Th1 and Th17 in Patients with Aplastic Anemia

Abstract: The upregulation of IL-27 might cause Th1 differentiation and immune disorders in AA patients. Blocking the expression of IL-27 could therefore be a reasonable therapeutic strategy for AA.

Cited by 21 publications

References 37 publications

A Cytokine‐Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood

A Cytokine‐Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood

The Immunobiology of Interleukin-27

Enhanced recruitment and hematopoietic reconstitution of bone marrow‐derived mesenchymal stem cells in bone marrow failure by the SDF‐1/CXCR4

Contact Info

Product

Resources

About