Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report

Guadarrama-Ortíz, Parménides; Oca-Vargas, Ingrid Montes de; Choreño-Parra, José Alberto; Gallegos-Garza, C.; Sánchez-Garibay, Carlos; Garibay-Gracián, André; Salinas-Lara, Citlaltépetl; Guinto, Gerardo

doi:10.1016/j.inat.2021.101374

Cited by 2 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-6 is produced by meningioma cells but does not stimulate tumor growth, whereas IL-6 mediates the differentiation of osteoblast and osteocytes into osteoclasts. Therefore, the role of IL-6 in hyperostosis in meningiomas is attributed to the effect of bone resorption rather than to tumor cell growth [32], [37]. The limitation of our study is that it did not examine IL-6 expression associated with the mechanism of hyperostosis.…”

Section: Discussionmentioning

confidence: 93%

“…MMP is a calcium-dependent zinc-containing endopeptidase that degrades extracellular matrix (ECM) and is involved in the penetration of tumor cells into adjacent tissues. This molecule initiates angiogenesis and the bioactive processes of proteins such as cytokines, chemokines, and cell surface receptors [32]. Bone is mainly composed of type I, type V, and type VI collagen.…”

Section: Discussionmentioning

confidence: 99%

“…Expression of MMP9 was correlated with expression of VEGF in meningiomas. The combined data of MMP-2, MMP-9, and VEGF expressions in the meningioma with skull infiltration may reveal the critical role of angiogenesis in determining bone invasiveness of these tumors [32], [33], [34], [35], [36].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Correspondence of Meningioma Orbital Grading and Clinicopathological Features among Indonesian Patients

Janah

Rujito

Wahyono

2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Orbital meningiomas can cause visual disturbances, protrusion of the eyes, double vision, and optic nerve abnormalities that significantly decrease vision and eventually lead to blindness. To the best of our knowledge, data on the incidence and pathogenesis of orbital meningioma in Indonesia are non-existent. AIM: This study aimed to analyze the clinicopathological relationship with orbital meningioma grading. METHODS: It is a cross-sectional observational analysis on 44 orbital meningioma patients in Dr. Hasan Sadikin General Hospital and the National Eye Center, Cicendo Eye Hospital in 2017–2020. Chi-square analysis and logistic regression with statistical significance (p < 0.05) were engaged in the method. RESULTS: Orbital meningioma mostly occurred in women aged 30–44 years. Meningioma Grade I was dominated by meningothelial meningioma found in 14 (31.8%) patients, Grade II was atypical meningioma in 9 (20.9%) patients, and Grade III was anaplastic meningioma in 3 patients (6.8%). Clinical symptoms in the form of papillary atrophy (p = 0.046), visual acuity (p = 0.026), proptosis (p = 0.029), and hyperostosis (p = 0.024) were statistically significant and there was a significant difference between Grade I, Grade II, and Grade III using the Chi-square test. Logistic regression results showed that hyperostosis is significantly related to grading the orbital meningioma (p = 0.044) with an odds ratio of 0.206 (IK95% 0.04–0.955). CONCLUSION: Hyperostosis increases the grading of the orbital meningioma because it is related to the invasion of the tumor into the orbital bone and is a neoplastic process. The presence of hyperostosis which is more common in Grade III meningiomas can be used as one of the most important predictors of meningioma recurrence postoperatively. Nonetheless, our data add to the existing literature the potential points of anti-invasive adjuvant therapy attacks.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Correspondence of Meningioma Orbital Grading and Clinicopathological Features among Indonesian Patients

Janah

Rujito

Wahyono

2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…In human patients with CH, meningiomas have been shown to express high levels of IL-6, MMP-1, MMP-2, and MMP-9 with minimal expression of these molecular factors in normal brain parenchyma. 18,19 The pro-inflammatory effects of tumour-expressed IL-6 include activation JAK/STAT, PI3K/AKT, and MAPK pathways, and through these pathways osteoclast activation occurs resulting in bone destruction and resorption, which may allow tumour extension into the calvarium. 19,27 The role of tumour derived IL-6 contributing to CH in humans is further supported from the observation that tumours do not regrow, and CH does not progress, when calvarial bone is replaced following tumour resection.…”

Section: Meningiomas With Microscopic Evidence Of Calvarial Invasionmentioning

confidence: 99%

“…16,17 Elaboration of matrix metalloproteinases (MMP) 2-and À9, interleukin-6 (IL-6), and alkaline phosphatase (ALP) by the tumour have all been implicated as potential molecular mediators of CH in human meningiomas. [17][18][19] The objectives of this study were to describe the prevalence and imaging characteristics of CH in a population of cats with intracranial meningiomas, investigate possible associations of tumour histopathologic and molecular characteristics with the presence of CH, and compare progression free survival times (PFS) between cats with and without CH that were treated surgically. It was hypothesised that: (1) CH would be associated with histologic evidence of tumour invasion into the skull; (2) tumour expression of MMP-2, MMP-9, and IL-6 would be higher in cats with CH; (3) serum bonespecific alkaline phosphatase (ALP) concentrations would be higher in cats with CH; and (4) progression free survival time (PFS) following surgical treatment of meningioma would be superior in cats without CH.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance and computed tomographic imaging characteristics and potential molecular mechanisms of feline meningioma associated calvarial hyperostosis

Edwards,

Garcia Mora,

Fowler

et al. 2024

Vet Comparative Oncology

View full text Add to dashboard Cite

Meningiomas are the most common feline primary brain tumours, and calvarial hyperostosis (CH) is frequently documented in association with this neoplastic entity. The clinical significance of and mechanisms driving the formation of CH in cats with meningiomas are poorly understood, although tumour invasion into the skull and tumour production of cytokines and enzymes have been implicated as causes of CH in humans. This retrospective study investigated relationships between signalment, MRI or CT imaging features, histopathologic tumour characteristics, alkaline phosphatase (ALP) isoenzyme concentrations, tumour expression of matrix metalloproteinases (MMP)‐2, MMP‐9, and interleukin‐6 (IL‐6), and progression free survival times (PFS) following surgical treatment in 27 cats with meningiomas with (n = 15) or without (n = 12) evidence of CH. No significant differences in breed, age, sex, body weight, tumour grade, tumour volume, peritumoral edema burden, ALP isoenzyme concentrations, tumour Ki‐67 labelling indices or MMP‐2 or MMP‐9 expression and activity, or PFS were noted between cats with or without CH. There was a trend towards higher serum (p = .06) and intratumoral (p = .07) concentrations of IL‐6 in cats with CH, but these comparisons were not statistically significant. Histologic evidence of tumour invasion into bone was observed in 5/12 (42%) with CH and in no (0/6) cats without CH, although this was not statistically significant (p = .07). Tumour invasion into bone and tumour production of IL‐6 may contribute to the formation of meningioma associated CH in cats, although larger studies are required to further substantiate these findings and determine their clinical relevance.

show abstract

Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report

Cited by 2 publications

References 32 publications

Correspondence of Meningioma Orbital Grading and Clinicopathological Features among Indonesian Patients

Correspondence of Meningioma Orbital Grading and Clinicopathological Features among Indonesian Patients

Magnetic resonance and computed tomographic imaging characteristics and potential molecular mechanisms of feline meningioma associated calvarial hyperostosis

Contact Info

Product

Resources

About