2007
DOI: 10.1016/j.jaci.2007.08.022
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Expression of IL-9 receptor α chain on human germinal center B cells modulates IgE secretion

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Cited by 58 publications
(36 citation statements)
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“…In relation to this, TSLP levels have been found to be significantly increased in SF of RA patients and capable of stimulating TSLP receptor-expressing CD11c + myeloid dendritic cells to secrete chemokines, causing influx and subsequent activation of CD4 + T cells [7]. The strong connection between IL-9 and autoimmunity has also recently been highlighted by the demonstration of its potential role in T-cell-dependent B-cell differentiation, expansion and antibody production [3]. The correlation between IL-9 and lymphoid organization that we observed in the present study further confirms, in our opinion, the importance of IL-9 and IL-9-producing cells in the induction of autoimmunity in RA.…”
Section: Discussionmentioning
confidence: 96%
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“…In relation to this, TSLP levels have been found to be significantly increased in SF of RA patients and capable of stimulating TSLP receptor-expressing CD11c + myeloid dendritic cells to secrete chemokines, causing influx and subsequent activation of CD4 + T cells [7]. The strong connection between IL-9 and autoimmunity has also recently been highlighted by the demonstration of its potential role in T-cell-dependent B-cell differentiation, expansion and antibody production [3]. The correlation between IL-9 and lymphoid organization that we observed in the present study further confirms, in our opinion, the importance of IL-9 and IL-9-producing cells in the induction of autoimmunity in RA.…”
Section: Discussionmentioning
confidence: 96%
“…In this www.rheumatology.oxfordjournals.org regard, our demonstration of a strong expression of IL-9R (m-RNA and protein) in the synovium of RA patients, especially in those synovial samples displaying the presence of GCs, seems to be relevant. IL-9R has been demonstrated by Fawaz et al [3] to be expressed in GC B cells, and its expression seems to be functional, because stimulation with IL-9 results in upregulation of phosphorylation of the transcription factors signal transducer and activator of transcription (STAT)3 and STAT5 and the ability of IL-9 to potentiate IgE production.…”
Section: Discussionmentioning
confidence: 99%
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“…However, they are also present in the respiratory mucosa, and their capacity to produce IgE locally in tissues has been demonstrated (31). Following exposure to allergens, production of IgE is triggered by key Th2 cytokines IL-4 and IL-13, with IL-9 participating by enhancing IgE synthesis in situ (32,33). Regulatory functions have also been attributed to B cells through secretion of IL-10, but the role of different subsets of B cells in allergic diseases remains to be determined (6).…”
Section: B Cells and Cd23 Participate In Antigen Presentationmentioning
confidence: 99%
“…134 Interleukin-9 enhances IL-4 dependent IgE production in B cells via the activation of STAT3 and STAT5, although IL-9 alone does not have this effect. 135 Transforming growth factor-β induces CSR to IgA by the activation of Smad and Runx. 134 Interleukin-10 is known to induce CSR to IgG 1 , IgG 3 , IgG 4 and IgA.…”
Section: Cytokinesmentioning
confidence: 99%