Expression of immune-regulatory molecules in circulating tumor cells derived from patients with head and neck squamous cell carcinoma

Chikamatsu, Kazuaki; Tada, Hiroe; Takahashi, Hideyuki; Kuwabara-Yokobori, Yuki; Ishii, Hiroki; Ida, Shota; Shino, Masato

doi:10.1016/j.oraloncology.2018.12.002

Cited by 35 publications

(30 citation statements)

References 33 publications

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“…The results of the present study are in accordance with other studies investigating CTCs in solid cancers, including the head and neck, which revealed that the presence of CTCs may influence prognosis (11)(12)(13)(14)(15)(16)(17)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57) similar to what was observed in the patients in the present study (6/8 were positive to CTC preoperatively). A recent meta-analysis comprised of 17 studies confirmed the significant prognostic value of CTCs in patients with head and neck cancer, wherein positive CTCs were significantly associated with poor overall, disease-free and progression-free survival (61).…”

Section: Discussionsupporting

confidence: 92%

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

et al. 2020

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The presence of circulating tumor cells (CTCs) in the blood of patients with metastatic breast, colorectal and prostate cancer have been widely investigated; however, few studies have examined CTCs in patients with laryngeal cancer. The present pilot study aimed to detect pre-and postoperative CTCs in the blood of patients with laryngeal cancer and evaluate the association with prognosis. Eight patients with laryngeal squamous cell carcinoma (LSCC) at stage III were included in the present study and underwent total or subtotal laryngectomy and radical bilateral neck lymph node dissection. Blood samples were collected from all patients before and after surgery at different time-points. The following processing steps were followed; preoperative blood sampling, surgery, postoperative blood sampling at 3, 6 and 12 month follow-ups, and prognostic association analysis. CTCs were retained on ScreenCell filters for cytological characterization. The presence of CTCs was associated with a less favorable prognosis, whereas a decrease of CTCs in the postoperative sampling was observed in patients who exhibited an improved therapeutic response. The results of the present pilot study revealed a possible association between the presence of CTCs and a less favorable prognosis in patients with LSCC; therefore, these preliminary findings may encourage further research into the incorporation of a liquid biopsy in the management of LSCC, as this may help identify patients with occult metastatic disease earlier and in a non-invasive manner. In addition, this approach may represent novel independent prognostic factor for use in the clinical evaluation of patients with LSCC.

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Section: Discussionsupporting

confidence: 92%

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

et al. 2020

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“…Some biomarkers can be isolated from body fluids, such as blood, urine, and saliva, and objectively measured . Important benefits of liquid biomarkers include their non‐invasive nature, and convenience in terms of taking serial measurements .…”

Section: Biomarkers From Liquid Biopsiesmentioning

confidence: 99%

“…More recently, markers from liquid biopsies that are directly related to cancer cells or cancer‐produced molecules have been employed, including circulating tumor cells (CTCs), cell‐free DNA (cfDNA)/circulating tumor DNA (ctDNA), cfRNA, and exosomes . It is generally accepted that CTCs may play an important role in cancer metastasis .…”

Section: Biomarkers From Liquid Biopsiesmentioning

confidence: 99%

“…Some biomarkers can be isolated from body fluids, such as blood, urine, and saliva, and objectively measured. [148][149][150][151] Important benefits of liquid biomarkers include their noninvasive nature, and convenience in terms of taking serial measurements. 152 However, a number of factors have the potential to impact the dynamics and reliability of liquid markers, limiting their clinical utility.…”

Section: Biomarkers From Liquid Biopsiesmentioning

confidence: 99%

“…188 However, some are not always cancer-specific, giving rise to problems in distinguishing between malignant and inflammatory disease. [189][190][191][192] More recently, markers from liquid biopsies that are directly related to cancer cells or cancer-produced molecules have been employed, including circulating tumor cells (CTCs), 147,[150][151][152][153][154][155][156][157][158][159][160][161][162][163][164]193,194 cell-free DNA (cfDNA)/ circulating tumor DNA (ctDNA), [187][188][189][190][191][192]195,196 cfRNA, 184 and exosomes. [196][197][198] It is generally accepted that CTCs may play an important role in cancer metastasis.…”

Section: Biomarkers From Liquid Biopsiesmentioning

confidence: 99%

See 2 more Smart Citations

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Hsieh

Wang

et al. 2019

Head & Neck

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Background Biomarkers in head and neck squamous cell carcinoma (HNSCC) emerge rapidly in recent years, especially for new targeted therapies and immunotherapies. Methods Recent, relevant peer‐reviewed evidence were critically reviewed and summarized. Results This review article briefly introduces essential biomarker concepts, including purposes and classifications (predictive, prognostic, and diagnostic markers), and the phases of biomarker development. We summarize current biomarkers in order of clinical utility; p16 and human papillomavirus status remain the most important and validated biomarkers in HNSCC. The rationale for biomarker study design continues to evolve with technological advances, especially whole‐exome or whole‐genomic sequencing. Noninvasive body fluid and liquid biopsy biomarkers appear to hold strong potential for development as tools for early cancer detection, cancer diagnosis, monitoring of disease recurrence, and outcome prediction. In light of discrepancies among different technologies, standardized approaches are needed. Conclusion Biomarkers from cancer tissue or blood in HNSCC could direct new anticancer therapies.

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Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Masmoudi,

Vialaret,

Hirtz

et al. 2024

Molecular Oncology

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Circulating tumor cells (CTCs) are cancer cells that detach from the original site and reach the bloodstream. The most aggressive CTCs survive various immune system attacks and initiate metastasis formation. Importantly, CTCs are not specifically targeted by the current immunotherapies due to the limited knowledge on specific targets. Proteomic profiling can be a powerful tool for understanding some of the immune evasion mechanisms used by cancer cells and particularly CTCs. These mechanisms are generally linked to the expression of specific surface proteins/peptides (i.e. the surfaceome). The study of the peptides that bind to class I molecules of the major histocompatibility complex (MHC‐I) and of the various glycoproteins expressed on CTC surface may open a completely new avenue for the discovery of novel mechanisms of immune evasion. In this review, we discuss how immunopeptidomic and glycoproteomic studies of CTCs that interact with immune cells could help to better understand how metastasis‐initiator CTCs escape the host immune response. We also describe how immunopeptidomic and glycoproteomic studies are carried out.

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Expression of immune-regulatory molecules in circulating tumor cells derived from patients with head and neck squamous cell carcinoma

Cited by 35 publications

References 33 publications

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

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