2010
DOI: 10.2460/ajvr.71.8.915
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Expression of inflammation-associated genes in circulating leukocytes collected from horses with gastrointestinal tract disease

Abstract: Inflammatory gene expression in leukocytes of horses with GIT disease appeared to be related to disease pathogenesis and prognosis.

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Cited by 16 publications
(14 citation statements)
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“…Circulating cytokines TNF-a, IL-1, IL-6, IL-8, and MCP-1 (CCL2) in humans are associated with a prothrombotic state, [8][9][10] and whereas an activated coagulation and/or increased DD concentrations were found during severe gastrointestinal, ischemic disorders in horses, Lopes et al successfully detected mRNA up-regulation of TNF-a, IL-1RA, IL-6, and IL-8 in PBMC under similar conditions of gastrointestinal disease. 6,21,22 Furthermore, TNF-a concentration increases in plasma and abdominal fluids from horses with these conditions have also been detected. 23,24 Although these results suggest that there is evidence of concurrent cytokine and DD production, it is possible that DD production in horses/ponies during EHV-1 viremia is also cytokine-driven.…”
Section: Discussionmentioning
confidence: 94%
“…Circulating cytokines TNF-a, IL-1, IL-6, IL-8, and MCP-1 (CCL2) in humans are associated with a prothrombotic state, [8][9][10] and whereas an activated coagulation and/or increased DD concentrations were found during severe gastrointestinal, ischemic disorders in horses, Lopes et al successfully detected mRNA up-regulation of TNF-a, IL-1RA, IL-6, and IL-8 in PBMC under similar conditions of gastrointestinal disease. 6,21,22 Furthermore, TNF-a concentration increases in plasma and abdominal fluids from horses with these conditions have also been detected. 23,24 Although these results suggest that there is evidence of concurrent cytokine and DD production, it is possible that DD production in horses/ponies during EHV-1 viremia is also cytokine-driven.…”
Section: Discussionmentioning
confidence: 94%
“…2010) and systemically in common inflammatory diseases of the horse (Nieto et al . 2009; Lopes et al . 2010; Peiro et al .…”
Section: Discussionmentioning
confidence: 99%
“…TNF is an important inflammatory mediator and increased concentrations have been detected locally in inflamed equine synovial tissue (Kamm et al 2010) and systemically in common inflammatory diseases of the horse (Nieto et al 2009;Lopes et al 2010;Peiro et al 2010). Human platelets and platelet-derived microparticles constitutively express TNF receptors I and II, and upregulation of the receptors has been observed when platelets are activated (Limb et al 1999;Baj-Krzyworzeka et al 2002).…”
Section: Discussionmentioning
confidence: 99%
“…In foals, several studies have been conducted comparing innate gene expressions in blood leukocytes in septic patients versus non-septic [79] and healthy foals [10, 11]. In adult horses leukocyte immune genes have been correlated to type of disease and outcome in patients with gastrointestinal inflammation and strangulation [12] while a small number of studies have had a primary aim of investigating leukocyte innate immune gene expressions in experimental lipopolysaccharide- (LPS-) induced systemic inflammation [1315]. These studies all encourage further investigations of the diagnostic potential of the immunological disease processes in equine systemic inflammation.…”
Section: Introductionmentioning
confidence: 99%