Expression of Insulin-Like Growth Factor-I (IGF-I) in Aneurysmal Bone Cyst

Leithner, Andreas; Lang, Susanna; Windhager, Reinhard; Leithner, Katharina; Karlic, Heidrun; Kotz, R.; Haas, Oskar A.

doi:10.1038/modpathol.3880443

Cited by 27 publications

(14 citation statements)

References 45 publications

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“…Furthermore, as described, the agents have a multifactorial action, which is related to the inhibition of MMP production, angiogenesis, and osteoclast function, as well as to the induction of osteoclast apoptosis and promotion of osteoblast regeneration. These findings are consistent with the description of ABC as a clonal tumor expressing high levels of MMPs and vascular endothelial growth factor, which has a high osteoclast activity and presents a blockage in osteoblast maturation [28][29][30][31][32]38].…”

Section: Nosupporting

confidence: 91%

“…ABCs are considered as primary lesions in approximately 70% of cases, with the remaining 30% arising secondary to different primary tumors, including giant cell tumor, unicameral bone cyst, and chondroblastoma [5]. As regards the primary ABC pathogenesis, currently, the presence of a chromosomal translocation t(16;17) (q22;p13), as a recurring abnormality and overexpression of insulinlike growth factor confirms the hypothesis that primary ABC is a true neoplastic lesion [29][30][31]. Matrix metalloproteinase-9 (MMP) induction in response to the presence of the fusion protein ubiquitinspecific protease 6 plays an important role in the pathogenesis and osteoclast destructive activity [32].…”

Section: Resultsmentioning

confidence: 91%

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Primary Aneurysmal Bone Cyst of Long Bones Treated with a Single Dose of Calcitonin and Methylprednisolone Percutaneous Intralesional Injection: A Case Series and Literature Review

Oliveira¹,

Meohas²,

Carvalho³

et al. 2017

J Orthop Oncol

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Aneurysmal bone cyst is a rare benign bone tumor usually treated by surgery, which may in turn result in poor functional outcome and recurrence. This study aims to report a series of cases of primary ABC treated with a single dose of calcitonin and methylprednisolone injection. Six patients treated with a single-dose combination of calcitonin (200 UI) and methylprednisolone (120 mg) at a single institution from January 2011 to December 2013 were clinically and radiologically evaluated. After the follow-up period, all patients presented cyst healing. The mean time to healing was 2.8 months. The final mean overall functional score rating was 89.0%. We conclude that intralesional calcitonin and methylprednisolone injection results in aneurysmal bone cyst healing with good functional outcomes and thus can be an effective treatment method.

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Section: Nosupporting

confidence: 91%

Section: Resultsmentioning

confidence: 91%

Primary Aneurysmal Bone Cyst of Long Bones Treated with a Single Dose of Calcitonin and Methylprednisolone Percutaneous Intralesional Injection: A Case Series and Literature Review

Oliveira¹,

Meohas²,

Carvalho³

et al. 2017

J Orthop Oncol

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“…ABC are rare, rapidly growing benign bone tumors that account for 1–2% of all primary bone tumors [26]. de Silva et al [27] reported that 80% of ABC occurred within the first 2 decades of life, with a mean age at presentation of 16.1 years.…”

Section: Discussionmentioning

confidence: 99%

Aneurysmal Bone Cyst of the Petrous Bone: Case Presentation and Review of the Literature

Sayama

MacDonald

2010

Pediatr Neurosurg

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Aneurysmal bone cysts (ABC) were originally described by Jaffe and Lichtenstein [Arch Surg 1942;44:1004–1025] in 1942 as nonneoplastic benign lesions with obscure pathogenesis. ABC occurring in the temporal bone are uncommon. Those arising from the petrous portion of the temporal bone are exceedingly rare. We report a right petrous ABC in a 16-year-old girl who presented clinically with hearing loss, facial weakness, and facial numbness and tingling. Her symptoms were preceded by a coincidental traumatic concussion 4 months earlier. Preoperative magnetic resonance imaging and computed tomography findings were both consistent with an ABC, although the lesion was noted to be in a very unusual location. Surgical resection was performed with adjuvant preoperative embolization. The patient recovered complete facial sensation and movement, and follow-up imaging documented complete resection.

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“…Is ABC a primary pathologic lesion or just a secondary lesion? 4,5 In approximately one third (29%Y35%) of ABC cases, the preexisting lesion can be identified, of which the giant cell tumor take the majority (about 19%Y39%). 5Y7 As to the remaining two thirds, it is considered that their origins are probably different.…”

Section: Discussionmentioning

confidence: 99%

Complete Resection and Immediate Reconstruction With Costochondral Graft for Recurrent Aneurysmal Bone Cyst of the Mandibular Condyle

Zhang

Yang

Chen

et al. 2013

Journal of Craniofacial Surgery

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Aneurysmal bone cyst is a non-neoplastic expansile lesion characterized by replacement with fibro-osseous tissue and blood-filled cavernous spaces. Involvement of the condyle is rare, and only 11 cases have been reported in English-language literature to date. Its common treatment modalities are lesion excision or condylar resection, but recurrence is high in patients treated with the former. The authors reported a 19-year-old female patient with swelling of the right preauricular region, who had a surgical curettage history in another hospital. The lesion was completely resected and the jaw was immediately reconstructed with costochondral graft with the help of SurgiCase software. The patient has been symptom-free for 6 months postoperatively.

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Expression of Insulin-Like Growth Factor-I (IGF-I) in Aneurysmal Bone Cyst

Cited by 27 publications

References 45 publications

Primary Aneurysmal Bone Cyst of Long Bones Treated with a Single Dose of Calcitonin and Methylprednisolone Percutaneous Intralesional Injection: A Case Series and Literature Review

Primary Aneurysmal Bone Cyst of Long Bones Treated with a Single Dose of Calcitonin and Methylprednisolone Percutaneous Intralesional Injection: A Case Series and Literature Review

Aneurysmal Bone Cyst of the Petrous Bone: Case Presentation and Review of the Literature

Complete Resection and Immediate Reconstruction With Costochondral Graft for Recurrent Aneurysmal Bone Cyst of the Mandibular Condyle

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