Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia

Дубова, Е. А.; Павлов, К. А.; Lyapin, V.M.; Kulikova, G. V.; Щеголев, А. И.; Сухих, Г. Т.

doi:10.1007/s10517-014-2502-4

Cited by 18 publications

(12 citation statements)

References 12 publications

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“…However, studies on very premature children born small for gestational age have reported that they may be less likely to have catch-up in linear growth, or only after 6 years of age [25]. IGF-I is one of the most important regulators of postnatal growth and is known to be lower in placental tissues and cord blood in women with severe, but not mild, PE [26, 27]. Therefore, poor linear growth in children exposed to severe PE might be due to effects on the growth hormone- IGF-1 axis [28–30], an effect that might be mediated through inflammation or perhaps the result of fetal programming.…”

Section: Discussionmentioning

confidence: 99%

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

et al. 2017

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Background and objectiveAn adverse intrauterine environment may affect offspring growth and development. Our aim was to explore whether preeclampsia (PE) exposure in utero influences growth from birth to 13 years.MethodsIn a nested case-control study, 229 children were exposed to PE (mild/moderate: n = 164, severe: n = 54) and 385 were unexposed. Length/height and weight were abstracted from records at birth, 3 and 6 months, 1 and 4 years, and measured along with waist circumference and skinfolds at follow-up at 11/12 (girls/boys) and 13 years (both sexes). Associations between PE and z-scores for growth were analyzed by multiple linear and fractional polynomial regression with adjustment for potential confounders.ResultsIn boys, exposure to mild/moderate PE was positively associated with linear growth after 0.5 years, but severe PE was negatively associated with linear growth in all ages. In girls, both exposure to mild/moderate and severe PE were negatively associated with linear growth. Exposure to PE was negatively associated with weight and body mass index (BMI) during infancy, but positively associated with weight and BMI thereafter, except that boys exposed to severe PE consistently had a lower weight and BMI compared to the unexposed. Exposure to severe PE only was positively associated with waist-to-height ratio at 11/12 (girls/boys) and 13 years (both sexes).ConclusionsFrom birth to adolescence, linear growth, weight and BMI trajectories differed between the sexes by severity of exposure to PE. In general, PE exposure was negatively associated with linear growth, while in girls; positive associations with weight and BMI were observed. This underlines fetal life as a particularly sensitive period affecting subsequent growth and this may have implications for targeted approaches for healthy growth and development.

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Section: Discussionmentioning

confidence: 99%

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

et al. 2017

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“…Similarly, we found the insulin-like growth factor-1 (IGF-1) expression to be decreased. IGF-1 was reported to be decreased in placental tissues from women suffering PE [ 51 ]. Of note is that 38 miRNAs that putatively regulate IGF-1 ( Table 4 ) were upregulated in our study.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts

Cross

Tolba

Rondelli

et al. 2015

BioMed Research International

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The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE in villous 3A first trimester trophoblast cells exposed to H2O2 at 12 different concentrations (0-1 mM) for 0.5, 4, 24, and 48 h. Cytotoxicity, determined using the SRB assay, was used to calculate the IC50 of H2O2. RNA was extracted after 4 h exposure to H2O2 for miRNA and gene expression profiling. H2O2 exerted a concentration- and time-dependent cytotoxicity on 3A trophoblast cells. Short-term exposure of 3A cells to low concentration of H2O2 (5% of IC50) significantly altered miRNA profile as evidenced by significant changes in 195 out of 595 evaluable miRNAs. Tool for annotations of microRNAs (TAM) analysis indicated that these altered miRNAs fall into 43 clusters and 34 families, with 41 functions identified. Exposure to H2O2 altered mRNA expression of 22 out of 84 key genes involved in dysregulation of placental development. In conclusion, short-term exposure of villous first trimester trophoblasts to low concentrations of H2O2 significantly alters miRNA profile and expression of genes implicated in placental development.

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“…However, circulating levels of IGF-I have been found lower in preeclamptic women [ 3 , 4 , 5 , 39 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. Furthermore, low placental IGF-I expression [ 47 , 50 ] and levels [ 39 ] have been found in preeclampsia. As shown for IGF-I, maternal circulating PTHrP levels have been found lower in preeclamptic women [ 51 , 52 ].…”

Section: Calcitriol In Preeclamptic Pregnancymentioning

confidence: 99%

Vitamin D and Inflammatory Cytokines in Healthy and Preeclamptic Pregnancies

et al. 2015

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Preeclampsia is a pregnancy disease characterized by hypertension and proteinuria. Among several disorders, the imbalance of inflammatory cytokines and the alteration of vitamin D metabolism have been reported in preeclampsia. The effects of calcitriol upon inflammatory cytokines has been demonstrated. In healthy pregnant women there is a shift toward a Th2 cytokine profile, which is necessary for an adequate pregnancy outcome. As compared with normal pregnancy, high pro-inflammatory and low anti-inflammatory cytokine levels have been observed in preeclamptic women. Preeclampsia has been associated with low calcitriol levels and vitamin D deficiency is correlated with a higher risk of the development of this disease. It has been demonstrated that placenta is a source as well as the target of calcitriol and cytokines and placental dysfunction has been associated with preeclampsia. Therefore, the present manuscript includes a review about serum calcitriol levels in non-pregnant, pregnant, and preeclamptic women as well as a review on the fetoplacental vitamin D metabolism in healthy and preeclamptic pregnancies. In addition, circulating and fetoplacental inflammatory cytokines in healthy and preeclamptic pregnancies are reviewed. Finally, the effects of calcitriol upon placental pro-inflammatory cytokines are also explored. In conclusion, maternal and placental calcitriol levels are low in preeclampsia which may explain, at least in part, high pro-inflammatory cytokine levels in this disease.

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Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia

Cited by 18 publications

References 12 publications

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts

Vitamin D and Inflammatory Cytokines in Healthy and Preeclamptic Pregnancies

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