Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer

Zhang, Hua; Shen, Tianyu; Zhang, Zheng; Yang, Li; Pan, Zhijuan

doi:10.12659/msm.917352

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…This functional diversity results from the combination of a conserved core motor domain and ATP-dependent catalytic cycle with family-specific domains adapted for specialized functions. One important role of kinesins is in the regulation of MT dynamics and MT length, as underscored by the contribution of the kinesin-8 and kinesin-13 families to accurate chromosome segregation, for example (Bakhoum et al, 2009, Stumpff et al, 2008, Zhang et al, 2019.…”

Section: Introductionmentioning

confidence: 99%

Multimodal tubulin binding by the yeast kinesin-8, Kip3, underlies its motility and depolymerization

Arellano-Santoyo

Hernández-López

Stokasimov

et al. 2021

Preprint

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The microtubule (MT) cytoskeleton is central to cellular processes including axonal growth, intracellular transport, and cell division, all of which rely on precise spatiotemporal control of MT organization. Kinesin-8s play a key role in regulating MT length by combining highly processive directional motility with MT-end disassembly. However, how kinesin-8 switches between these two apparently opposing activities remains unclear. Here, we define the structural features underlying this molecular switch through cryo-EM analysis of the yeast kinesin-8, Kip3 bound to MTs, and molecular dynamics simulations to approximate the complex of Kip3 with the curved tubulin state found at the MT plus-end. By integrating biochemical and single-molecule biophysical assays, we identified specific intra- and intermolecular interactions that modulate processive motility and MT disassembly. Our findings suggest that Kip3 undergoes conformational changes in response to tubulin curvature that underlie its unique ability to interact differently with the MT lattice than with the MT-end.

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Section: Introductionmentioning

confidence: 99%

Multimodal tubulin binding by the yeast kinesin-8, Kip3, underlies its motility and depolymerization

Arellano-Santoyo

Hernández-López

Stokasimov

et al. 2021

Preprint

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show abstract

“…In this study, a large number of sample information analysis based on multiple data sets showed that KIF18A expression was increased in a variety of tumor tissues [13,15,[35][36][37] (Figure 1a), and the expression of KIF18A mRNA ( Figure 1b) and protein ( Figure 7) in glioma was signi cantly increased. Therefore, KIF18A expression was increased in gliomas, and its relationship with glioma and its function were further veri ed.…”

Section: Discussionmentioning

confidence: 62%

High Expression Levels of KIF18A is an Independent Predictor of Poor Survival in Glioma: A Study Using Multi Public Data

Chang¹,

Wang²,

Li³

et al. 2020

Preprint

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Background: Kinesin family member 18A (KIF18A) belongs to a member of the kinesin superfamily and is significantly overexpressed and abnormally functions in a variety of cancers. However, the expression profiling and the role of KIF18A has so far remained unclear in glioma. To investigate the relationship of KIF18A with clinical practice and its role in gliomas, the data from multi public datasets were used and analyzed in present study.Methods: Patients with gliomas were enrolled from CGGA RNA-seq, TCGA-seq, CGGA-microarray, GSE4290 and GSE50161 databases. The expression of KIF18A in glioma and normal tissues was analyzed through Wilcoxon rank sum test, and the relationship between KIF18A and clinicopathological features was evaluated using logistic regression. The effect of KIF18A expression in the survival of glioma patients was explored by Kaplan-Meier and Cox analyses. Gene set enrichment analysis was also conducted to annotate biological function of KIF18A.Results: KIF18A expression was significantly increased in glioma tissues compared with the normal counterparts. High KIF18A expression shortened the overall survival in all grades gliomas and the survival period of patients with WHO grade Ⅲ glioma, but not significantly for grade Ⅱ and grade Ⅳ glioma. Univariate and multivariate analyses demonstrated that evaluated KIF18A expression is closely related to poor prognosis. Increased KIF18A expression was significantly correlated grades, age, IDH wide type and may serve as a biomarker of poor prognosis in gliomas. GSEA showed that the KEGG_DNA_REPLICATION, the KEGG_CELL_CYCLE, the KEGG_MISMATCH_REPAIR and the KEGG_NUCLEOTIDE_EXCISION_REPAIR were differentially enriched in KIF18A high expression phenotype.Conclusions: High expression KIF18A might be potential biomarker for the diagnosis and an independent risk factor for poor prognosis in glioma.

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“…Prostate cancer [52] Gastric cancer [53] Lung cancer [54] Breast cancer [55] Liver cancer [56] Kinesin-10 KIF22 High Breast cancer [57] Kinesin-11 KIF26B High Breast cancer [58] Osteosarcoma [59] Kinesin-12 KIF15 High Breast cancer [60] Osteosarcoma [61] Kinesin-13 KIF2C High…”

Section: Kifs In Cancer Biologymentioning

confidence: 99%

Kinesin superfamily proteins: roles in osteosarcoma

Song

Xue³

et al. 2021

Front. Biosci. (Landmark Ed)

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Background: Osteosarcoma is a common bone tumor with extremely high malignancy, occurring mostly in children and adolescents. At present, the survival rate of osteosarcomas has made progress in some aspects; however, this can only be regarded as a partial success because substantial progress has not been made in the last few decades. Object: The kinesin superfamily is a group of proteins that play regulatory roles in various metabolic processes and are closely related to tumor metastasis. Increasing evidence shows that kinesins play key roles in the occurrence and development of human cancer. Purpose: This review summarizes the roles of the kinesin superfamily proteins in osteosarcoma and related functions.Abbreviations: ATPase, adenosine triphosphatase; KIFs, kinesin superfamily protein.

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Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer

Cited by 16 publications

References 38 publications

Multimodal tubulin binding by the yeast kinesin-8, Kip3, underlies its motility and depolymerization

Multimodal tubulin binding by the yeast kinesin-8, Kip3, underlies its motility and depolymerization

High Expression Levels of KIF18A is an Independent Predictor of Poor Survival in Glioma: A Study Using Multi Public Data

Kinesin superfamily proteins: roles in osteosarcoma

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