Expression of KIR2DS1 does not significantly contribute to NK cell cytotoxicity in HLA-C1/C2 heterozygous haplotype B donors

Baltner, Karla; Kübler, Ayline; Pal, Marina; Balvočiūtė, Monika; Mezger, Markus; Handgretinger, Rupert; André, Maya C.

doi:10.1093/intimm/dxx052

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…HLA-C allotypes, including the C1 or the C2 epitope, act as ligands for KIRs. Inhibitory KIR2DL1 receptors and activating KIR2DS1 receptors bind to the C2 epitope, while inhibitory KIR2DL2/3 receptors bind to the C1 epitope ( 47 , 48 ). The binding strength of inhibitory receptors is higher than that of activating receptors upon binding to the same epitope.…”

Section: Kir/hla Interactionsmentioning

confidence: 99%

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

Wei

Zhang

et al. 2022

Front. Immunol.

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Successful embryo implantation requires both a receptive endometrium and competent blastocysts. After implantation, the maternal decidua undergoes a series of changes, including uterine spiral artery (SA) remodeling to accommodate the fetus and provide nutrients and oxygen for the fetus to survive. Uterine spiral arteries transform from small-diameter, high-resistance arteries to large-diameter and low-resistance arteries during pregnancy. This transformation includes many changes, such as increased permeability and dilation of vessels, phenotypic switching and migration of vascular smooth muscle cells (VSMCs), transient loss of endothelial cells (ECs), endovascular invasion of extravillous trophoblasts (EVTs), and presence of intramural EVT, which are regulated by uterine NK (uNK) cells and EVTs. In this review, we mainly focus on the separate and combined roles of uNK cells and EVTs in uterine SA remodeling in establishing and maintaining pregnancy. New insight into related mechanisms will help us better understand the pathogenesis of pregnancy complications such as recurrent pregnancy loss (RPL) and preeclampsia (PE).

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Section: Kir/hla Interactionsmentioning

confidence: 99%

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

Wei

Zhang

et al. 2022

Front. Immunol.

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“…Considering the particular susceptibility of patients with leukemia undergoing myeloablative conditioning regimens to subsequent CMV infection, it is theoretically attractive to exploit adaptive NK cells of CMV‐positive individuals not only to boost antiviral immunity but more so to make use of the theoretically achievable expansion of the in fact minute alloreactive KIR2DS1 + NK cell subset in HLA‐C1/C2 donors which is highly responsive toward C2‐expressing targets . With this intention, a phase I clinical trial in AML patients has been initiated by Sarah Cooley and colleagues, which will determine the maximal tolerated dose (MTD) of so‐called FATE‐NK100 cells (NK cells of a donor previously exposed to CMV) in conjunction with IL‐2 and combination chemotherapy (NCT03081780, Table ).…”

Section: Efficacy Of Memory‐like Nk Cellsmentioning

confidence: 99%

From bench to bedside: Exploiting memory NK cell responses to leukemia

Schmidt

André

2018

Adv Cell Gene Ther

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The exploitation of natural killer (NK) cell-mediated antileukemic responses in its various facets (emergence of alloreactive NK cells early posttransplantation, cotransfer of mature NK cells during graft manipulation, and adoptive transfer of mature NK cells) has recently come into the focus (reviewed by Handgretinger et al 1 ). Recent publications indicate that NK cells-although belonging per definition to the innate immune system-may acquire under certain conditions (such as high concentrations of cytokines or viral and presumably also tumor antigens) features of adaptive immune cells. 2 Depending on the initiating stimulus, we distinguish these memory NK cells as cytomegalovirus-induced, cytokine-induced, or tumor-induced memory NK cells. Theoretically, these memory NK cells should entail a higher clinical efficacy 1 as they are long-lived, vividly expand, Abstract Natural killer (NK) cells belong to innate lymphoid immune cells that contribute to antitumor responses without requiring prior sensitization. There is strong evidence that NK cells may induce graft-vs-leukemia (GvL) effect without causing graft-vs-host disease (GvHD), and significant efforts are currently undertaken to design and optimize NK cell-based immunotherapeutic strategies against human cancers, particularly against leukemias. However, the results of a number of adoptive NK cell transfer How to cite this article: Schmidt M, André MC. From bench to bedside: Exploiting memory NK cell responses to leukemia.Adv Cell Gene Ther. 2019;2:e28. https://doi.

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“…Natural killer (NK) cells are an important component of the innate immune system, they are typically cluster of differentiation (CD)3 − CD56 + cells, which and are primarily distributed in the peripheral blood, with 10–15% in lymphocytes ( 17 , 18 ). NK cells are responsible for immune surveillance without antigen presentation and major histocompatibility complex (MHC) restriction ( 19 ). Once activated, NK cells are able to recognize target cells rapidly and release cytotoxic effector molecules to trigger the immune response ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Propofol improves the function of natural killer cells from the peripheral blood of patients with esophageal squamous cell carcinoma

et al. 2018

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Postoperative immunosuppression is associated with the recurrence and metastasis of esophageal squamous cell carcinoma (ESCC). Propofol is a commonly used intravenous anesthetic and has been reported to be associated with immunosuppression; however, little is known about its effect on innate immune cells during the postoperative period in patients with ESCC. The aim of the present study was to investigate the effects of propofol on the phenotype and cytotoxicity of natural killer (NK) cells derived from the peripheral blood of patients with ESCC. The percentage, phenotype and function of NK cells were compared between patients with ESCC and healthy volunteers using flow cytometry. NK cells were negatively sorted using magnetic beads and cocultured with propofol to assess changes in phenotype and function. The results revealed that the percentage of NK cells was significantly increased in the peripheral blood of patients with ESCC, while their activity and cytotoxicity were impaired. NK cells were successfully separated from peripheral blood in vitro and it was demonstrated that propofol enhanced their activity by influencing the expression of activating or inhibitory receptors. Furthermore, propofol was able to increase the cytotoxicity of NK cells from the peripheral blood of patients with ESCC. These results suggest that propofol is able to improve the function of NK cells in patients with ESCC and may therefore be an appropriate anesthetic for ESCC surgery.

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Expression of KIR2DS1 does not significantly contribute to NK cell cytotoxicity in HLA-C1/C2 heterozygous haplotype B donors

Cited by 5 publications

References 40 publications

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

From bench to bedside: Exploiting memory NK cell responses to leukemia

Propofol improves the function of natural killer cells from the peripheral blood of patients with esophageal squamous cell carcinoma

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