Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta

Terao, Yasuko; Kumano, Satoshi; Takatsu, Yoshihiro; Hattori, Motonobu; Nishimura, Atsushi; Ohtaki, Tetsuya; Shintani, Yasushi

doi:10.1016/j.bbaexp.2004.02.005

Cited by 169 publications

(155 citation statements)

References 28 publications

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“…1B). The third amino acid residue of Kp-10, tryptophan, is fully conserved in the mammals that have been reported previously [e.g., human (9), rodents (24,25), ruminants (16), and pigs (17)], but is replaced by arginine in the musk shrew.…”

Section: Resultsmentioning

confidence: 89%

Kisspeptin neurons mediate reflex ovulation in the musk shrew ( Suncus murinus )

Inoue

Sasagawa

Ikai

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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The present study investigated whether kisspeptin-G protein-coupled receptor 54 (GPR54) signaling plays a role in mediating mating-induced ovulation in the musk shrew (Suncus murinus), a reflex ovulator. For this purpose, we cloned suncus Kiss1 and Gpr54 cDNA from the hypothalamus and found that suncus kisspeptin (sKp) consists of 29 amino acid residues (sKp-29). Injection of exogenous sKp-29 mimicked the mating stimulus to induce follicular maturation and ovulation. Administration of several kisspeptins and GPR54 agonists also induced presumed ovulation in a dose-dependent manner, and Gpr54 mRNA was distributed in the hypothalamus, showing that kisspeptins induce ovulation through binding to GPR54. The sKp-29-induced ovulation was blocked completely by pretreatment with a gonadotropin-releasing hormone (GnRH) antagonist, suggesting that kisspeptin activates GnRH neurons to induce ovulation in the musk shrew. In addition, in situ hybridization revealed that Kiss1-expressing cells are located in the medial preoptic area (POA) and arcuate nucleus in the musk shrew hypothalamus. The number of Kiss1-expressing cells in the POA or arcuate nucleus was up-regulated or downregulated by estradiol, suggesting that kisspeptin neurons in these regions were the targets of the estrogen feedback action. Finally, mating stimulus largely induced c-Fos expression in Kiss1-positive cells in the POA, indicating that the mating stimulus activates POA kisspeptin neurons to induce ovulation. Taken together, these results indicate that kisspeptin-GPR54 signaling plays a role in the induction of ovulation in the musk shrew, a reflex ovulator, as it does in spontaneous ovulators.brain | copulation | Kiss1r | metastin | ovary

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Section: Resultsmentioning

confidence: 89%

Kisspeptin neurons mediate reflex ovulation in the musk shrew ( Suncus murinus )

Inoue

Sasagawa

Ikai

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…These data suggest a direct action of kisspeptin at the level of the hypothalamus, with a limited or no role in regulating HPG axis activity at the level of the pituitary. Both Kiss-1 and GPR54 mRNAs have been localized to the ovaries and the testes of rodents (Kotani et al 2001;Ohtaki et al 2001;Terao et al 2004;Castellano et al 2006a), and a functional kisspeptin-GPR54 system may provide a mechanism for local regulation of reproductive status at the level of the gonads, although this is at present only speculative.…”

Section: Kisspeptin Actions On the Hpg Axismentioning

confidence: 99%

Recent advances in reproductive neuroendocrinology: a role for RFamide peptides in seasonal reproduction?

et al. 2008

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Most temperate-zone species use photoperiod to coordinate breeding and ensure that offspring are born during favourable conditions. Although photoperiodic influences on the reproductive axis have been well characterized, the precise mechanisms by which photoperiodic information and other seasonal cues are integrated to regulate reproductive function remain less well specified. Two recently discovered neuropeptides, kisspeptin and gonadotropin-inhibitory hormone, have pronounced opposing influences on reproductive function. This paper will review recent evidence for a role of these peptides in seasonal reproduction and propose a theoretical framework by which these novel regulatory peptides may serve to regulate seasonal breeding. Understanding the mechanisms regulating appropriate changes in reproductive status will serve to advance a wide range of life science disciplines.

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“…A product of the KISS1 gene, kisspeptin, is cleaved from an initial 145 amino acid precursor to a 54 amino acid peptide in humans (Kotani et al 2001, Ohtaki et al 2001) and a 52 amino acid peptide in mice (Terao et al 2004). In humans, smaller isoforms of 14 and 13 amino acids have also been isolated, each sharing the common C-terminal sequence (Kotani et al 2001, Ohtaki et al 2001.…”

Section: Kisspeptin Governs Puberty Onset and Reproductionmentioning

confidence: 99%

Kisspeptin and energy balance in reproduction

Bond¹,

Smith²

2014

Reproduction

105

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Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons are now recognized as a central pathway responsible for conveying key homeostatic information to GNRH neurons. This pathway is likely to mediate the well-established link between energy balance and reproductive function. Thus, in states of severely altered energy balance (either negative or positive), fertility is compromised, as is Kiss1 expression in the arcuate nucleus. A number of metabolic modulators have been proposed as regulators of kisspeptin neurons including leptin, ghrelin, pro-opiomelanocortin (POMC), and neuropeptide Y (NPY). Whether these regulate kisspeptin neurons directly or indirectly will be discussed. Moreover, whether the stimulatory role of leptin on reproduction is mediated by kisspeptin directly will be questioned. Furthermore, in addition to being expressed in GNRH neurons, the kisspeptin receptor (Kiss1r) is also expressed in other areas of the brain, as well as in the periphery, suggesting alternative roles for kisspeptin signaling outside of reproduction. Interestingly, kisspeptin neurons are anatomically linked to, and can directly excite, anorexigenic POMC neurons and indirectly inhibit orexigenic NPY neurons. Thus, kisspeptin may have a direct role in regulating energy balance. Although data from Kiss1r knockout and WT mice found no differences in body weight, recent data indicate that kisspeptin may still play a role in food intake and glucose homeostasis. Thus, in addition to regulating reproduction, and mediating the effect of energy balance on reproductive function, kisspeptin signaling may also be a direct regulator of metabolism.

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Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta

Cited by 169 publications

References 28 publications

Kisspeptin neurons mediate reflex ovulation in the musk shrew ( Suncus murinus )

Kisspeptin neurons mediate reflex ovulation in the musk shrew ( Suncus murinus )

Recent advances in reproductive neuroendocrinology: a role for RFamide peptides in seasonal reproduction?

Kisspeptin and energy balance in reproduction

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