Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis

Kolić, Ivana; Stojković, Ljiljana; Dinčić, Evica; Jovanović, Ivan; Stanković, Aleksandra; Živković, Maja

doi:10.1016/j.jneuroim.2019.577090

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…The PPARGC1A rs8192678 (Gly482Ser) was very recently found to confer an increased risk for the occurrence of MS and lipid/metabolic disorders [ 79 ]. The finding of lower mRNA levels in MS than in control IJV walls is compatible with the reduced mRNA expression in peripheral blood mononuclear cells of RR-MS [ 80 ] and with reduced expression of PPARGC1A and neuronal loss in MS cortex [ 81 ].…”

Section: Discussionmentioning

confidence: 63%

Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis

Scapoli

Ziliotto

Lunghi

et al. 2021

IJMS

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Aiming at exploring vascular components in multiple sclerosis (MS) with brain outflow disturbance, we combined transcriptome analysis in MS internal jugular vein (IJV) wall with WES in MS families with vertical transmission of disease. Main results were the differential expression in IJV wall of 16 MS-GWAS genes and of seven genes (GRIN2A, GRIN2B, IL20RB, IL26, PER3, PITX2, and PPARGC1A) not previously indicated by GWAS but encoding for proteins functionally interacting with MS candidate gene products. Strikingly, 22/23 genes have been previously associated with vascular or neuronal traits/diseases, nine encoded for transcriptional factors/regulators and six (CAMK2G, GRIN2A, GRIN2B, N1RD1, PER3, PPARGC1A) for circadian entrainment/rhythm components. Among the WES low-frequency (MAF ≤ 0.04) SNPs (n = 7) filtered in the 16 genes, the NR1D1 rs17616365 showed significantly different MAF in the Network for Italian Genomes affected cohort than in the 1000 Genome Project Tuscany samples. This pattern was also detected in five nonintronic variants (GRIN2B rs1805482, PER3 rs2640909, PPARGC1A rs2970847, rs8192678, and rs3755863) in genes coding for functional partners. Overall, the study proposes specific markers and low-frequency variants that might help (i) to understand perturbed biological processes in vascular tissues contributing to MS disease, and (ii) to characterize MS susceptibility genes for functional association with disease-pathways.

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Section: Discussionmentioning

confidence: 63%

Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis

Scapoli

Ziliotto

Lunghi

et al. 2021

IJMS

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“…CPT1B is involved in the β‐oxidation process of long‐chain fatty acids in muscle mitochondria (van der Leij et al, 2002). LEP and PNPLA2 are mainly associated with lipid degradation (Cruz‐Color et al, 2020), whereas PPARGC1A is co‐involved in mitochondrial β‐oxidation as a downstream of LEP (Kolić et al, 2020). ADIPOQ is an adipose factor expressed only in adipocytes and involved in adipocyte differentiation and inhibition of fatty acid oxidation (Martinez‐Huenchullan et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…associated with lipid degradation(Cruz-Color et al, 2020), whereas PPARGC1A is co-involved in mitochondrial β-oxidation as a downstream of LEP(Koli c et al, 2020). ADIPOQ is an adipose factor expressed only in adipocytes and involved in adipocyte differentiation and inhibition of fatty acid oxidation(Martinez-Huenchullan et al, 2018).…”

mentioning

confidence: 99%

Effect of high‐concentrate diets on mRNA expression of genes related to muscle fiber type and metabolism of psoas major muscle in goats

Ren¹,

Li²,

Xu³

et al. 2022

Animal Science Journal

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In the process of modern breeding, high‐concentrate diets are widely used to meet the high energy nutritional requirements of animals but change the form of access to energy and nutrients and the way the organism metabolizes them. Goat psoas major (PM) muscle is a hybrid skeletal muscle whose characteristics are important for the motility and meat quality of goats. However, there are few studies on the effects of high‐concentrate diets on the muscle type and metabolic characteristics of PM in goats. In this study, two treatment groups were set up: high concentrate group (HC) and control group (C). The expression of genes related to muscle type and metabolism of the PM was examined by quantitative PCR. The results showed that high concentrate promoted the conversion of PM fibers from intermediate to slow type at the mRNA level, improved the absorption, transport, and oxidation of fat by PM, and upregulated the expression of calpain system. These changes may be regulated by the involvement of differential expression of MSTN, Myf‐5, and IGF‐2. These results suggest that high concentrate may exert a positive effect on skeletal muscle function, metabolism, and meat quality in goats by affecting the expression of muscle type and metabolism‐related genes.

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“…While some studies have measured the serum levels of neuropeptides in PCOS women (4-9), few studies have focused on the expression of the genes encoding these neuropeptides in peripheral blood (6,10). Previous studies have stated that the mRNA expressions of these genes were detected in peripheral blood (11)(12)(13). Since the secretion of KISS1 is influenced by many factors, such as dynorphin, NKB, LEP, and NPY, it would be interesting to study their role in the context of women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study

Hestiantoro,

Al Maghfira,

Fathmasari

et al. 2024

IJRM

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Background: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS). Objective: This study compares the expression levels of KISS1, dynorphin, neurokinin-B, leptin, and neuropeptide-Y in women with and without PCOS. Materials and Methods: In this cross-sectional study, the peripheral blood samples of 20 women with PCOS and 20 women without PCOS who referred to Yamin Kencana Clinic, Cipto Mangunkusumo hospital, Jakarta, Indonesia were enrolled from August-December 2022. mRNA relative expression of genes related to the central factors associated with PCOS, such as leptin, neuropeptide-Y, KISS1, tachykinin-3, and prodynorphin (PDYN), in PCOS and non-PCOS populations were examined. Gene quantification was carried out by the quantitative polymerase chain reaction method. Results: The KISS1/PDYN ratio was significantly higher in the PCOS group than in the control group (p = 0.02), and the PDYN was lower in the PCOS group than the control group (p < 0.001). Moreover, the positive correlation between KISS1 and the KISS1/PDYN ratio was significantly stronger in the PCOS group than in the control group (R = 0.93; p < 0.001 vs. R = 0.66, p < 0.001). Conclusion: Our results suggest that an increased KISS1/PDYN ratio in PCOS women is related to diminished dynorphin expression. Low expression of the gene encoding dynorphin and a high KISS1/PDYN ratio is highly specific to PCOS. Key words: Dynorphins, Kisspeptins, Neuropeptides, Polycystic ovary syndrome.

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Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis

Cited by 6 publications

References 35 publications

Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis

Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis

Effect of high‐concentrate diets on mRNA expression of genes related to muscle fiber type and metabolism of psoas major muscle in goats

Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study

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