Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells

Mariee, Najat; Li, Tin‐Chiu; Laird, Susan

doi:10.1093/humrep/des134

Cited by 77 publications

(69 citation statements)

References 32 publications

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“…In agreement with these findings, another recently published study demonstrated a correlation between stromal IL15 and the number of uNK cells. However, in disagreement with these studies, it has been reported that women with repeated implantation failure have higher IL15 in the stroma compared with controls (Mariee et al 2012). …”

Section: Local Injury-induced Increase In Endometrial Receptivity Is mentioning

confidence: 86%

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

2012

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Implantation failure, which is presently the major barrier in human fertility, is attributed, in many cases, to the failure of the uterus to acquire receptivity. The transition into a receptive uterus includes cellular changes in the endometrium and the modulated expression of different cytokines, growth factors, transcription factors, and prostaglandins. These molecules partake in the generation of an inflammatory response followed by the recruitment of immune cells. These cells have shown to be involved in the maternal immune tolerance toward the implanted embryo as well as in the maternal-fetus interaction during pregnancy. Most of the accumulated evidence indicates that embryo implantation is associated with an active Th1 inflammatory response while a Th2-humoral inflammation is required for pregnancy maintenance. Yet, recent findings suggest that a Th1 inflammatory response is also necessary for the acquisition of uterine receptivity. This notion was originally suggested by reports from our and other clinical centers worldwide that IVF patients with repeated implantation failure subjected to endometrial biopsy exhibit a substantial improvement in their chances to conceive. These findings, followed by the demonstration of an elevated pro-inflammatory cytokine/chemokine expression, as well as an increased abundance of immune cells, in the endometrium of these patients, raised the idea that acquisition of uterine receptivity is closely associated with an inflammatory response. This review summarizes the molecular and biochemical evidence that confirm this notion and proposes a mechanism by which injury-induced inflammation improves uterine receptivity and the subsequent pregnancy outcome.Reproduction (2012) 144 661-668

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Section: Local Injury-induced Increase In Endometrial Receptivity Is mentioning

confidence: 86%

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

2012

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“…This association has suggested regulation by progesterone, but uNK cells do not express progesterone receptor or oestrogen receptor (ER)α Henderson et al 2003 ). Regulation of uNK cells by progesterone could occur indirectly via products of decidualised endometrial stromal cells; endometrial stromal cells produce interleukin (IL)-15 in the late secretory phase of the cycle and early pregnancy, and immunostaining for IL-15 has been shown to correlate with numbers of CD56+ cells in endometrium from women with recurrent miscarriage and implantation failure (Mariee et al 2012 ). uNK cells do, however, express ERβ and glucocorticoid receptor (Henderson et al 2003 ).…”

Section: Distribution Of Unk Cellsmentioning

confidence: 99%

“…Although IL-2 is not present in normal endometrium, IL-15 has been detected in stromal cells in luteal phase endometrium and early pregnancy decidua; secretion is stimulated by progesterone, although the regulation of this appears complex (Okada et al 2000 ), involving IL-1-β (Okada et al 2004 ) and IFNγ ( Dunn et al 2002 ). Studies of luteal phase endometrium in women with recurrent reproductive failure have shown a correlation between uNK cell number and stromal cell IL-15 levels (Mariee et al 2012 ). Although no data are available for human uNK cells, IL-11 is required for mouse uNK cell maturation (Ain et al 2004 ).…”

Section: Regulation Of Unk Cells By Growth Factors In Endometriummentioning

confidence: 99%

The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders

Bulmer

Lash

2015

Advances in Experimental Medicine and Biology

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The human endometrium contains a substantial population of leucocytes which vary in distribution during the menstrual cycle and pregnancy. An unusual population of natural killer (NK) cells, termed uterine NK (uNK) cells, are the most abundant of these cells in early pregnancy. The increase in number of uNK cells in the mid-secretory phase of the cycle with further increases in early pregnancy has focused attention on the role of uNK cells in early pregnancy. Despite many studies, the in vivo role of these cells is uncertain. This chapter reviews current information regarding the role of uNK cells in healthy human pregnancy and evidence indicating their importance in various reproductive and pregnancy problems. Studies in humans are limited by the availability of suitable tissues and the limitations of extrapolation from animal models.

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“…These 2 elements complement each other, promoting recovery of endometrium. As known, HOXA10 was a marker of endometrial receptivity [20,21]. An expression of sufficient HOXA10 mRNA is essential to endometrial receptivity and embryo implantation [22].…”

Section: Discussionmentioning

confidence: 96%

Small Intestine Submucosa Is a Potential Material for Intrauterine Adhesions Treatment in a Rat Model

Kong

Zhang²,

Xu³

et al. 2017

Gynecol Obstet Invest

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Objective: To study whether small intestine submucosa (SIS) could be a treatment option for preventing the formation of intrauterine adhesions (IUAs). Methods: The IUAs model was established by mechanical curettage and infectious injury in a rat model. One uterine horn of the rat model was treated with the transplantation of SIS (SIS group) and the other one was left without any treatment (control group). The endometrium was evaluated with endometrial thickness, number of glands and fibrosis area. The endometrial receptive factors were detected by quantitative real-time polymerase chain reaction The number and location of embryos were documented to assess the function of endometrium. Results: In the SIS group, endometrial thickness was significantly thicker than that in the control group on the 14th and 21st day and the percentage of fibrosis area was significantly lower during the entire observation process (p < 0.05). The number of glands was similar between the 2 groups (p > 0.05). Receptive factors changed as follows: in the SIS group, the expression of uteroglobin was higher and peaked on the 21st day (3.42-fold, p < 0.05); the HOXA10 level was significantly higher on the 10th day (2.16-fold, p < 0.05), and it then decreased. More embryos were seen in SIS horns (5.13 vs. 1.25, p < 0.05). Conclusions: SIS could be a potential physical barrier for the formation of IUAs. It contributes to the regeneration of and improvement of the receptivity of endometrium, and helps in the implantation and development of embryos in a rat model.

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Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells

Cited by 77 publications

References 32 publications

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

Endometrial inflammation and effect on implantation improvement and pregnancy outcome

The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders

Small Intestine Submucosa Is a Potential Material for Intrauterine Adhesions Treatment in a Rat Model

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