Expression of long non-coding RNA CCHE1 in colorectal carcinoma: correlations with clinicopathological features and ERK/COX-2 pathway

Gaballah, Hanaa Hibishy; Gaber, Rasha A.; Elrashidy, Mohamed; Elshahat, Dina A.; Hablus, Mohamed A; Ebeid, Abla M.

doi:10.1007/s11033-018-4521-0

Cited by 20 publications

(18 citation statements)

References 31 publications

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“…The present study observed that the expression levels of CCEPR were significantly increased in colorectal cancer tissues and cell lines when compared with adjacent normal tissues and non-tumour HIEC cells, respectively. Consistent with these observations, Gaballah et al (20) also reported that CCEPR expression was upregulated in 60 colorectal cancer tissues than in adjacent normal tissues. The current study also demonstrated that the expression levels of CCEPR were higher in advanced colorectal cancer tissues (stage III/IV) compared with early-stage colorectal cancer tissues (stage I/II).…”

Section: Discussionmentioning

confidence: 66%

“…In addition, CCEPR exerts oncogenic roles in gastric cancer, lung cancer, bladder cancer and liver cancer (16–19). Recently, Gaballah et al (20) identified that CCEPR expression is significantly upregulated in colorectal cancer, and its expression is positively correlated with the expression of phosphorylated (p)-ERK1/2, cyclooxygenase (COX)-2, cyclin D1 and PCNA (20). This suggests that CCEPR may be involved in colorectal cancer progression by modulating the ERK/COX-2 signalling pathway and cell proliferation activity.…”

Section: Introductionmentioning

confidence: 99%

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Knockdown of lncRNA CCEPR suppresses colorectal cancer progression

et al. 2019

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Long non-coding RNAs (lncRNAs) serve important roles in colorectal cancer. The aim of the present study was to investigate the expression and role of cervical carcinoma expressed PCNA regulatory (CCEPR) lncRNA in colorectal cancer progression. The results demonstrated that CCEPR expression was significantly higher in colorectal cancer tissues when compared with paired adjacent normal tissues. In addition, CCEPR expression was significantly higher in patients with advanced colorectal cancer (stage III/IV) than those with early-stage colorectal cancer (stage I/II). High CCEPR expression was significantly associated with poor differentiation, advanced clinical stage, positive lymph node metastasis and distant metastasis. Of particular note, patients with colorectal cancer exhibiting high CCEPR expression levels had shorter survival rates when compared with patients with low CCEPR expression. In vitro experiments demonstrated that the expression of CCEPR was increased in colorectal cancer cell lines when compared with a normal colon cell line. Knockdown of CCEPR significantly inhibited colorectal cancer cell proliferation, colony formation and cell cycle progression, as well as cell migration and invasion. Finally, silencing of CCEPR downregulated matrix metalloproteinase (MMP)-2 and MMP-9 expression and suppressed epithelial-mesenchymal transition in colorectal cancer cells. In conclusion, the results of the present study suggest that CCEPR may exert an oncogenic role in colorectal cancer, and CCEPR may be a promising molecular target for colorectal cancer treatment.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Knockdown of lncRNA CCEPR suppresses colorectal cancer progression

et al. 2019

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“…Cervical carcinoma expressed PCNA regulatory lncRNA (CCEPR) is localized to chromosome 10q21.1 and has been frequently upregulated in several common types of cancer, such as gastric, liver, cervical, lung, colorectal and bladder cancers ( 15 – 20 ). Overexpression of CCEPR predicts a poor prognosis for cervical cancer ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

et al. 2020

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Cervical carcinoma expressed PCNA regulatory long non-coding (lnc)RNA (CCEPR) has recently been reported to play oncogenic roles in some common types of human cancer. However, the clinical significance of CCEPR mRNA expression levels in esophageal squamous cell carcinoma (ESCC) and the exact function of CCEPR in regulating the malignant phenotypes of ESCC cells have not been previously investigated. In the present study, CCEPR mRNA expression level was upregulated in ESCC tissues and cell lines, and overexpression of CCEPR was associated with advanced TNM stage, lymph node metastasis, and poor prognosis in ESCC. In vitro experiments showed that silencing CCEPR mRNA expression levels significantly suppressed the proliferation, migration, and invasion of ESCC cells, while inducing ESCC cell apoptosis. Furthermore, inhibition of CCEPR decreased the protein expression levels of matrix metalloproteinase (MMP)2 and MMP9 and inhibited epithelial-mesenchymal transition in ESCC cells. In conclusion, the results showed that CCEPR plays an oncogenic role in ESCC and suggests that CCEPR could be used as a potential therapeutic target for ESCC treatment.

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“…Expression of the cervical carcinoma expressed PCNA regulatory (CCEPR) lncRNA (also referred to as cervical carcinoma high-expressed long non-coding RNA 1; CCHE1) is highly upregulated in cervical cancers and expression correlates with tumor size and poor prognosis of cervical cancer patients [32,94,95]. High level CCEPR expression has also been noted in other tumor types including osteosarcoma [96], uroepithelial bladder carcinoma [97], non-small cell lung carcinoma [98], hepatocellular carcinoma [99] and colorectal carcinoma [100]. Our own work revealed that CCEPR lncRNA is expressed at higher levels in HPV16 E6/E7 expressing HFKs than in parental HFKs [93].…”

Section: Ccepr (Cche1)mentioning

confidence: 99%

The Role of Long Noncoding RNAs in Human Papillomavirus-associated Pathogenesis

Sharma

Münger

2020

Pathogens

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Infections with high-risk human papillomaviruses cause ~5% of all human cancers. E6 and E7 are the only viral genes that are consistently expressed in cancers, and they are necessary for tumor initiation, progression, and maintenance. E6 and E7 encode small proteins that lack intrinsic enzymatic activities and they function by binding to cellular regulatory molecules, thereby subverting normal cellular homeostasis. Much effort has focused on identifying protein targets of the E6 and E7 proteins, but it has been estimated that ~98% of the human transcriptome does not encode proteins. There is a growing interest in studying noncoding RNAs as biochemical targets and biological mediators of human papillomavirus (HPV) E6/E7 oncogenic activities. This review focuses on HPV E6/E7 targeting cellular long noncoding RNAs, a class of biologically versatile molecules that regulate almost every known biological process and how this may contribute to viral oncogenesis.

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Expression of long non-coding RNA CCHE1 in colorectal carcinoma: correlations with clinicopathological features and ERK/COX-2 pathway

Cited by 20 publications

References 31 publications

Knockdown of lncRNA CCEPR suppresses colorectal cancer progression

Knockdown of lncRNA CCEPR suppresses colorectal cancer progression

Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

The Role of Long Noncoding RNAs in Human Papillomavirus-associated Pathogenesis

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