On March 11, 2020, the World Health Organization declared the coronavirus (COVID‐19) outbreak a global pandemic, spurring dramatic changes in public health policies, travel between countries, and (trans)national economies, as well as in religious and political institutions. In the United States, in particular, the pandemic provoked and revealed an increasingly fraught relationship between scientific, religious, and political sources of information and leadership—an American “crisis of authority” wherein many Americans distrusted scientific and medical establishments. This article explores how Shi‘i Muslim institutions and leaders of metro Detroit navigated these competing authorities, even as their communities faced entrenched societal inequities, including anti‐Muslim racism (Islamophobia). Through interviews with Shi‘i religious leaders in Dearborn, Dearborn Heights, and Detroit, supplemented by digital and in‐person ethnographic research at five major Shi‘i mosques, we show how major Islamic centers and leaders argued for the efficacy, safety, religious value, and legality of COVID‐19 medical guidance and led extensive community outreach initiatives to help their struggling communities. Supported by religious scholars in Iran, Iraq, and Lebanon, their guidance offered messages of hope and resilience, as well as an emphasis on the community preservation and selflessness (caring for others) exemplified by the Family of the Prophet. They also emphasized how religious and scientific knowledge intersect, as per the sacred texts of Islam (the Qur'an and hadiths). Their approach compels us to better understand how sources of religious authority can tether vulnerable communities to forms of (legitimate) knowledge in times of upheaval, divisive politics, and misinformation.