Expression of &lt;b&gt;&lt;i&gt;AdipoR1&lt;/i&gt;&lt;/b&gt; and &lt;b&gt;&lt;i&gt;AdipoR2&lt;/i&gt;&lt;/b&gt; and Serum Level of Adiponectin in Gastric Cancer

Kordafshari, Morteza; Nourian, Mahyar; Mehrvar, Narjes; Jalaeikhoo, Hassan; Etemadi, Aida; Khoshdel, Ali Reza; Idris, Mohammad Ghaznavi; Iravani, Siavash; Mehrvar, Azim

doi:10.1159/000510342

Cited by 8 publications

(6 citation statements)

References 30 publications

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“…Adiponectin receptors (ADIPORs) are membrane proteins implicated in the control of glucose and lipid metabolism. Different studies have determined the incidence relationship of certain cancers with polymorphisms of the genes that code for ADIPORs [ 152 , 153 , 154 ]. Moreover, several studies have demonstrated the efficiency of ADIPORs agonists to induce cell death in cancer cells, such as (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-acetamide) in cholangiocarcinoma [ 155 ], ADP355 in prostate cancer [ 156 ] or AdipoRon with pancreatic cancer cells [ 157 ].…”

Section: Enzymes Of Ceramide Metabolismmentioning

confidence: 99%

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer

et al. 2021

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Sphingolipids are both structural molecules that are essential for cell architecture and second messengers that are involved in numerous cell functions. Ceramide is the central hub of sphingolipid metabolism. In addition to being the precursor of complex sphingolipids, ceramides induce cell cycle arrest and promote cell death and inflammation. At least some of the enzymes involved in the regulation of sphingolipid metabolism are altered in carcinogenesis, and some are targets for anticancer drugs. A number of scientific reports have shown how alterations in sphingolipid pools can affect cell proliferation, survival and migration. Determination of sphingolipid levels and the regulation of the enzymes that are implicated in their metabolism is a key factor for developing novel therapeutic strategies or improving conventional therapies. The present review highlights the importance of bioactive sphingolipids and their regulatory enzymes as targets for therapeutic interventions with especial emphasis in carcinogenesis and cancer dissemination.

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Section: Enzymes Of Ceramide Metabolismmentioning

confidence: 99%

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer

et al. 2021

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“…The dysregulation of ADIPOR1/2 is observed in various cancers. A study reported that both ADIPOR1 and ADIPOR2 are highly increased in gastric cancer samples from patients in Iran ( 8 ). Adrenal cancers are also associated with ADIPOR1 and ADIPOR2.…”

Section: Introductionmentioning

confidence: 99%

Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis

et al. 2023

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IntroductionAdipoR1 and AdipoR2 proteins, encoded by ADIPOR1 and ADIPOR2 genes respectively, are the receptors of adiponectin secrected by adipose tissue. Increasing studies have identified the vital role of adipose tissue in various diseases, including cancers. Hence, there is an urgent need to explore the roles of AdipoR1 and AdipoR2 in cancers.MethodsWe conducted a comprehensive pan-cancer analysis for the roles of AdipoR1 and AdipoR2 via several public databases, including expression differences, prognostic value, and the correlations with tumor microenvironment, epigenetic modification, and drug sensitivity.ResultsBoth ADIPOR1 and ADIPOR2 genes are dysregulated in most cancers, but their genomic alteration frequencies are low. In addition, they are also correlated with the prognosis of some cancers. Although they are not strongly correlated with tumor mutation burden (TMB) or microsatellite instability (MSI), ADIPOR1/2 genes display a significant association with cancer stemness, tumor immune microenvironment, immune checkpoint genes (especially CD274 and NRP1), and drug sensitivity.DiscussionADIPOR1 and ADIPOR2 play critical roles in diverse cancers, and it is a potential strategy to treat tumors through targeting ADIPOR1 and ADIPOR2.

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“…19 In recent years, it has been found that ADIPOR1 also plays an important role in tumorigenesis, invasion, and metastasis. 20 - 23 As for ADIPOR1 and liver cancer, it reported that overexpressed miR-221 promoted epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma by targeting ADIPOR1, 24 and low expression of ADIPOR1 was associated with increased risk of recurrence and death in patients with liver cancer. 25 In this study, we identified ADIPOR1 as a prognostic marker for SBRT in patients with liver cancer through clinical information, high-throughput sequencing and qPCR analysis.…”

Section: Introductionmentioning

confidence: 99%

Screening of Prognostic Biomarkers for Stereotactic Body Radiation Therapy in Primary Liver Cancer

et al. 2022

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Objective So far there are still no effective immediate-early markers for assessing the efficacy of Stereotactic Body Radiation Therapy (SBRT). To find effective biomarkers for accurate assessment of the efficacy of SBRT in patients with primary liver cancer, we conducted this study including retrospective part and prospective part. Material and Methods 589 patients with primary liver cancer were included at Ruikang Hospital affiliated to Guangxi Medical University from January 2012 to December 2018. Follow-up was conducted, clinical information and a total of 17 patients with 51 blood samples (before SBRT, before discharge and 2 months after SBRT) were collected. mRNAs profiles on 2 patients with 6 blood samples were detected by high-throughput sequencing, followed by qPCR verification on 15 patients with 45 blood samples. Results The commonly used serum biomarkers such as AFP, CEA, and CA125 shown low prognostic value in distinguishing survival group and death group, indicated by low AUC (less than .7) and Youden indexes (less than .5). Based on high-throughput sequencing of test group and qPCR detection of another verification group, we found 16 up-regulated and 12 downregulated genes after SBRT. Among them, ADIPOR1 and EPB42 showed significantly different between effective and ineffective group after SBRT, ROC suggested that based on the optimal threshold of .5838, ADIPOR1 shown a sensitivity of 100% and a specificity of 83.33% to distinguish effective from ineffective group. And EPB42 had a sensitivity of 75% and a specificity of 100% at the optimal threshold of 1.3817. In addition, GSEA showed that high expression of ADIPOR1 was mainly related to Mismatch repair, Circadian rhythm, Protein processing in endoplasmic reticulum, DNA replication, and Fanconi anemia pathways. Conclusion ADIPOR1 in whole blood is a promising candidate to act as prognostic biomarker for predication of SBRT outcomes in primary liver cancer patients.

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Expression of <b><i>AdipoR1</i></b> and <b><i>AdipoR2</i></b> and Serum Level of Adiponectin in Gastric Cancer

Cited by 8 publications

References 30 publications

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer

Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis

Screening of Prognostic Biomarkers for Stereotactic Body Radiation Therapy in Primary Liver Cancer

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