Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney

Lee, Hyun‐Wook; Yan-xia, Qin; Kim, Yumi; Park, Eun‐Young; Hwang, Jin-Sun; Huo, Guan-Hua; Yang, Chul-Woo; Kim, Wan-Young; Kim, Jin

doi:10.1007/s00441-010-1098-x

Cited by 43 publications

(57 citation statements)

References 51 publications

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“…Noteworthy, the expression of hyaluronidases there was restricted to macrophages but not reticular cells. Ultrastructually, LYVE-1 is always localized in the plasma membrane but not in the cytoplasm and cell organelle, in contrast to its cytoplasmic localization in macrophagic cells, such as intracellular vesicles and vacuoles (21,41). The dual membrane localization of LYVE-1 in the vascular endothelial cells is in agreement with early observations concerning LYVE-1 in the endothelium of lymphatics (29), suggesting transport via the cells (transcytosis) without intracellular degradation.…”

Section: Topographical and Functional Relationship Between Lyve-1-expsupporting

confidence: 79%

“…LYVE-1 has been believed to be a hyaluronan receptor molecule abundantly expressed in the endothelium of lymphatic vessels, with additional expressions in sinusoidal endothelia of the liver, lymph node, and spleen and in some macrophage lineages (1,3,21,26,41). However, we found a broader distribution of LYVE-1: vascular endothelial cells in the lung, adrenal gland, and endocardium.…”

Section: Lyve-1 Is a Novel Marker For The Reticulo-endothelial Systemcontrasting

confidence: 53%

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The selective distribution of LYVE-1-expressing endothelial cells and reticular cells in the reticulo-endothelial system (RES)

Zheng¹,

Kimura²,

Nio‐Kobayashi³

et al. 2016

Biomed. Res.

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LYVE-1, a receptor molecule for hyaluronan, is expressed in the lymphatic endothelium, blood sinus endothelium, and certain macrophage lineages. The present immunohistochemical study revealed a broader distribution of LYVE-1 in vascular endothelial cells of the murine lung, adrenal gland, and heart as well as the liver and spleen. In addition, sinus reticular cells-including sinuslining cells-in the medulla of the lymph node also intensely expressed LYVE-1. Ultrastructurally, immuno-gold particles for LYVE-1 were localized on the entire length of plasma membrane in all cell types. Most of these LYVE-1-expressing cells had previously been classified as the reticuloendothelial system (RES) specialized for eliminating foreign particles. An LPS stimulation decreased the LYVE-1 expression in macrophages but elevated the expression at mRNA and protein levels in the liver and lung, major organs for the elimination of blood-born waste substances. LYVE-1-expressing endothelial cells in these organs participated in the endocytosis of exogenous particles, and the uptake ability was conspicuously enhanced by the LPS challenge. Although the expression of the degrading enzyme, hyaluronidase, was generally low in the LYVE-1-expressing cells, they were topographically associated with a dense distribution of macrophages possessing hyaluronidase activities in each tissue. These findings suggest that the LYVE-1-expressing cells might be involved in the uptake of hyaluronan and other waste products as well as foreign particles circulating in the blood and lymph while participating in the subsequent degradation in relay with adjacent macrophage populations. LYVE-1 (lymphatic vessel endothelial hyaluronan receptor-1) has been identified as a reliable marker that is expressed predominantly in the lymphatic endothelium (5, 29). Both the chemical structure and function of LYVE-1 resemble those of a well-established hyaluronan receptor, CD44, which has a 41% similarity to LYVE-1 and is characterized as an inflammatory leukocyte homing receptor. CD44 is widely expressed in the epithelium, mesothelium, mesenchymal cells, and cells of hematopoietic origin (22), while LYVE-1 has been shown in early studies to display a restricted distribution to the lymphatic endothelium and be completely absent from blood vessels, except for sinusoidal endothelial cells in the spleen (5). Subsequent studies have also detected the expression of LYVE-1 in sinusoidal endothelial cells using paraffin sections of the liver, spleen and lymph node of humans (1, 26). However, our preliminary immunohistochemical study using frozen sections from rodents found a broader distribution of LYVE-1 in the endothelium of other organs, including the lung, adrenal gland, heart, and adenohypophysis. In addition, the sinus reticular cells in the medulla of the lymph node intensely expressed LYVE-1. Interestingly, most of these belong

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Section: Topographical and Functional Relationship Between Lyve-1-expsupporting

confidence: 79%

Section: Lyve-1 Is a Novel Marker For The Reticulo-endothelial Systemcontrasting

confidence: 53%

The selective distribution of LYVE-1-expressing endothelial cells and reticular cells in the reticulo-endothelial system (RES)

Zheng¹,

Kimura²,

Nio‐Kobayashi³

et al. 2016

Biomed. Res.

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“…Previous studies have shown that lymphatic ECs start to appear in the mouse kidney at E13.5 40 and that multiple cell types contribute to the their development, including venous derived ECs, mesenchymal cells, and hematopoietic cells. 41 ;R26 LacZ/+ mice suggests a distinct origin of lymphatic ECs from non-SCL+ precursors.…”

Section: Discussionmentioning

confidence: 99%

Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development

Li²,

Göthert

et al. 2015

JASN

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The close relationship between endothelial and hematopoietic precursors during early development of the vascular system suggested the possibility of a common yet elusive precursor for both cell types. Whether similar or related progenitors for endothelial and hematopoietic cells are present during organogenesis is unclear. Using inducible transgenic mice that specifically label endothelial and hematopoietic precursors, we performed fate-tracing studies combined with colony-forming assays and crosstransplantation studies. We identified a progenitor, marked by the expression of helix-loop-helix transcription factor stem cell leukemia (SCL/Tal1). During organogenesis of the kidney, SCL/Tal1 + progenitors gave rise to endothelium and blood precursors with multipotential colony-forming capacity. Furthermore, appropriate morphogenesis of the kidney vasculature, including glomerular capillary development, arterial mural cell coating, and lymphatic vessel development, required sphingosine 1-phosphate (S1P) signaling via the G protein-coupled S1P receptor 1 in these progenitors. Overall, these results show that SCL/Tal1 + progenitors with hemogenic capacity originate and differentiate within the early embryonic kidney by hemovasculogenesis (the concomitant formation of blood and vessels) and underscore the importance of the S1P pathway in vascular development.

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“…Another recent study on kidney in mouse embryos identifies the Lyve-1-positive cells as possessing F4/80 þ / CD11b À (macrophage/dendritic) antigen (Lee et al, 2011). These doublepositive cells were found to form part of the lymphatic vascular wall of the developing kidney.…”

Section: Developmental Dynamicsmentioning

confidence: 94%

Cellular phenotypes and spatio‐temporal patterns of lymphatic vessel development in embryonic mouse hearts

Flaht

Jankowska‐Steifer

Radomska

et al. 2012

Developmental Dynamics

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Di‐stereoblock polylactides (di‐sb‐PLA: PLLA‐b‐PDLA) having high molecular weight (Mn > 100 kDa) were successfully synthesized by two‐step ring‐opening polymerization (ROP) of L‐ and D‐lactides using tin(2‐ethylhexanoate) as a catalyst. By optimizing the polymerization conditions, the block sequences were well regulated at non‐equivalent feed ratios of PLLA and PDLA. This synthetic method consisted of three stages: (1) polymerization of either L‐ or D‐lactide to obtain a PLLA or PDLA prepolymer with a molecular weight less than 50 kDa, (2) purification of the obtained prepolymer to remove residual lactide, and (3) polymerization of the enantiomeric lactide in the presence of the purified prepolymer. Their 13C and 31P NMR spectra of the resultant di‐sb‐PLAs strongly supported their di‐stereo block structure. These di‐sb‐PLAs, having weight‐average molecular weights higher than 150 kDa, were fabricated into polymer films by solution casting and showed exclusive stereocomplexation. The thermomechanical analysis of the films revealed that their heat deformation temperature was limited probably because of their low crystallinity owing to the non‐equivalent PLLA/PDLA ratio. The blend systems of the di‐sb‐PLAs having complementary stereo‐sequences (the one with a long PLLA block and the other with long PDLA block) were also prepared and characterized to enhance the sc crystallinity. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 794–801, 2010

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Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney

Cited by 43 publications

References 51 publications

<b>The selective distribution of LYVE-1-expressing endothelial cells and reticular cells in the reticulo-endothelial system </b><b>(RES) </b>

<b>The selective distribution of LYVE-1-expressing endothelial cells and reticular cells in the reticulo-endothelial system </b><b>(RES) </b>

Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development

Cellular phenotypes and spatio‐temporal patterns of lymphatic vessel development in embryonic mouse hearts

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