Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas

Luo, Min; Huang, Yuhua; Ni, Yun‐Bi; Tsang, Julia Y. S.; Chan, Siu‐Ki; Shao, Mumin; Tse, Gary M.

doi:10.1016/j.humpath.2012.10.009

Cited by 58 publications

(54 citation statements)

References 21 publications

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“…Mammaglobin has a sensitivity of 42.3% and that of GCDFP-15 is 31.6% in detecting cancers of breast origin. Combined usage of mammaglobin and GCDFP increased sensitivity to 53.0% for primary tumours and 69.0% for nodal metastases 10. In our case, histopathological examination of this suspicious lung lesion was suggestive of adenocarcinoma as the primary breast cancer was also an adenocarcinoma.…”

Section: Discussionsupporting

confidence: 45%

Differential diagnosis of lung lesion in breast carcinoma: a metachronous neoplasm or metastasis?

et al. 2016

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A 34-year-old woman-a diagnosed case of pT1N1MO, stage IIa, estrogen and progesterone receptor positive (ER, PR) positive, Her2 negative carcinoma of the left breast-was managed with modified radical mastectomy and adjuvant chemotherapy. While planning for radiotherapy, she was found to have a well-defined enhancing lesion with spiculated margins in the superior segment of the right lower lobe along with a heterogeneously enhancing right hilar lymph node on CT. Histopathological evaluation of the lesion was suggestive of adenocarcinoma. The lesion was negative for ER, PR receptors, mammoglobin and gross cystic disease fluid protein. Thyroid transcription factor 1 (TTF-1) was positive, suggesting a primary lung adenocarcinoma rather than metastatic lesion from the breast. This case clearly signifies the importance of histopathological diagnosis of suspicious metastatic lesions in the setting of early breast cancer. We would also like to highlight the importance of TTF-1 in differentiating primary lung malignancy from metastasis.

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Section: Discussionsupporting

confidence: 45%

Differential diagnosis of lung lesion in breast carcinoma: a metachronous neoplasm or metastasis?

et al. 2016

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“…For that reason, a multitude of IHC markers are now used toward that end. Stains for mammaglobin and GCDFP-15 have been employed to potentially label secondary deposits of breast cancer, and the sensitivity of those markers has ranged from 10% to 80% in various reports [18,19]. In particular, their expression is said to be limited in high-grade ductal and lobular mammary adenocarcinomas [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…Stains for mammaglobin and GCDFP-15 have been employed to potentially label secondary deposits of breast cancer, and the sensitivity of those markers has ranged from 10% to 80% in various reports [18,19]. In particular, their expression is said to be limited in high-grade ductal and lobular mammary adenocarcinomas [18,19]. That is a troublesome finding because high-grade tumors are more likely to metastasize to distant sites [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Before the availability of GATA3, gross cystic disease fluid protein 15 (GCDFP-15) and mammaglobin were the 2 most commonly used IHC markers of mammary epithelial differentiation. However, those determinants are less than completely sensitive, especially with regard to highgrade breast carcinomas, with several studies showing diagnostic sensitivities of less than 50% [18,19]. In comparison, Miettinen et al [16] found that GATA3 was 93% sensitive and 100% specific for breast carcinoma in an analysis of 230 ductal tumors and 38 lobular lesions.…”

Section: Introductionmentioning

confidence: 99%

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GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin

Wendroth

Mentrikoski

Wick

2015

Annals of Diagnostic Pathology

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“…Interestingly, in addition to being an AR-regulated gene [64], PIP/GCDFP-15 has been demonstrated to be expressed in a large proportion of human breast cancers and to enhance the growth and invasion of breast cancer cell lines [68-71]. In addition, PIP was found to activate AR activity, which in turn, upregulates PIP transcription in feed-forward loop [70].…”

Section: Resultsmentioning

confidence: 99%

Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity

Sriram

Pryce

et al. 2015

Breast Cancer Res

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IntroductionPeriostin (Postn) is a secreted cell adhesion protein that activates signaling pathways to promote cancer cell survival, angiogenesis, invasion, and metastasis. Interestingly, Postn is frequently overexpressed in numerous human cancers, including breast, lung, colon, pancreatic, and ovarian cancer.MethodsUsing transgenic mice expressing the Neu oncogene in the mammary epithelium crossed into Postn-deficient animals, we have assessed the effect of Postn gene deletion on Neu-driven mammary tumorigenesis.ResultsAlthough Postn is exclusively expressed in the stromal fibroblasts of the mammary gland, Postn deletion does not affect mammary gland outgrowth during development or pregnancy. Furthermore, we find that loss of Postn in the mammary epithelium does not alter breast tumor initiation or growth in mouse mammary tumor virus (MMTV)-Neu expressing mice but results in an apocrine-like tumor phenotype. Surprisingly, we find that tumors derived from Postn-null animals express low levels of Notch protein and Hey1 mRNA but increased expression of androgen receptor (AR) and AR target genes. We show that tumor cells derived from wild-type animals do not proliferate when transplanted in a Postn-null environment but that this growth defect is rescued by the overexpression of active Notch or the AR target gene prolactin-induced protein (PIP/GCDFP-15).ConclusionsTogether our data suggest that loss of Postn in an ErbB2/Neu/HER2 overexpression model results in apocrine-like tumors that activate an AR-dependent pathway. This may have important implications for the treatment of breast cancers involving the therapeutic targeting of periostin or Notch signaling.Electronic supplementary materialThe online version of this article (doi:10.1186/s13058-014-0513-8) contains supplementary material, which is available to authorized users.

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Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas

Cited by 58 publications

References 21 publications

Differential diagnosis of lung lesion in breast carcinoma: a metachronous neoplasm or metastasis?

Differential diagnosis of lung lesion in breast carcinoma: a metachronous neoplasm or metastasis?

GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin

Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity

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