Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen

Martı́nez-Pomares, Luisa; Hanitsch, Leif G.; Stillion, Richard J.; Keshav, Satish; Gordon, Siamon

doi:10.1038/labinvest.3700327

Cited by 40 publications

(32 citation statements)

References 34 publications

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“…In humans, the MR has been detected in cells located within the dermis, lamina propria, and T cell areas of the tonsil (9), in inflammatory epidermal DCs from patients with atopic dermatitis (10), and in cells lining venous sinuses in the spleen (11). Evidence for the involvement of the MR in Ag presentation to the acquired immune system is limited and in some cases contradictory.…”

Section: Endritic Cells (Dcs)mentioning

confidence: 99%

Mannose Receptor Expression and Function Define a New Population of Murine Dendritic Cells

McKenzie

Taylor

Stillion

et al. 2007

The Journal of Immunology

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In vitro the mannose receptor (MR) mediates Ag internalization by dendritic cells (DC) and favors the presentation of mannosylated ligands to T cells. However, in vivo MR seems to play a role not in Ag presentation but in the homeostatic clearance of endogenous ligands, which could have the secondary benefit of reducing the levels of endogenous Ag available for presentation to the adaptive immune system. We have now observed that while MR+ cells are consistently absent from T cell areas of spleen and mesenteric lymph nodes (LN), peripheral LN of untreated adult mice contain a minor population of MR+MHCII+ in the paracortex. This novel MR+ cell population can be readily identified by flow cytometry and express markers characteristic of DC. Furthermore, these MR+ DC-like cells located in T cell areas can be targeted with MR ligands (anti-MR mAb). Numbers of MR+MHCII+ cells in the paracortex are increased upon stimulation of the innate immune system and, accordingly, the amount of anti-MR mAb reaching MR+MHCII+ cells in T cell areas is dramatically enhanced under these conditions. Our results indicate that the MR can act as an Ag-acquisition system in a DC subpopulation restricted to lymphoid organs draining the periphery. Moreover, the effect of TLR agonists on the numbers of these MR+ DC suggests that the immunogenicity of MR ligands could be under the control of innate stimulation. In accordance with these observations, ligands highly specific for the MR elicit enhanced humoral responses in vivo only when administered in combination with endotoxin.

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Section: Endritic Cells (Dcs)mentioning

confidence: 99%

Mannose Receptor Expression and Function Define a New Population of Murine Dendritic Cells

McKenzie

Taylor

Stillion

et al. 2007

The Journal of Immunology

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“…Nephrotoxicity is perhaps the most-described adverse event associated with AmpB (68) . The pathophysiology and pharmacology of this activity are well-documented, and the proposed mechanism has been described as multifactorial (69) (70) .…”

Section: Optimized Nanoparticle Delivery Systems For Ampb Based On Chmentioning

confidence: 99%

New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment

Chávez-Fumagalli

Ribeiro

Castilho

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization. It is a life-threatening disease of medical, social and economic importance in endemic areas. No vaccine is yet available for human use, and chemotherapy presents several problems. Pentavalent antimonials have been the drugs of choice to treat the disease for more than six decades; however, they exhibit high toxicity and are not indicated for children, for pregnant or breastfeeding women or for chronically ill patients. Amphotericin B (AmpB) is a second-line drug, and although it has been increasingly used to treat visceral leishmaniasis (VL), its clinical use has been hampered due to its high toxicity. This review focuses on the development and in vivo usage of new delivery systems for AmpB that aim to decrease its toxicity without altering its therapeutic efficacy. These new formulations, when adjusted with regard to their production costs, may be considered new drug delivery systems that promise to improve the treatment of leishmaniasis, by reducing the side effects and the number of doses while permitting a satisfactory cost-benefit rati

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“…In mammals, mannose receptor, C type 1 (Mrc1) is strongly expressed in macrophages and dendritic cells, prominently in lymphatics (Taylor et al, 2005b), and is involved in lymphocyte migration (Irjala et al, 2001;Marttila-Ichihara et al, 2008;Salmi et al, 2013), but is also expressed in sinusoidal endothelial cells (Takahashi et al, 1998), venous sinuses of the human spleen (Martinez-Pomares et al, 2005), and a subset of venous endothelial cells (Linehan et al, 1999). In zebrafish, mrc1a is expressed in primitive veins at early stages of zebrafish development (Wong et al, 2009), but its expression has not been investigated at later stages when lymphatic vessels develop.…”

Section: Introductionmentioning

confidence: 99%

Development of the larval lymphatic system in the zebrafish

et al. 2017

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The lymphatic vascular system is a hierarchically organized complex network essential for tissue fluid homeostasis, immune trafficking and absorption of dietary fats in the human body. Despite its importance, the assembly of the lymphatic network is still not fully understood. The zebrafish is a powerful model organism that enables study of lymphatic vessel development using high-resolution imaging and sophisticated genetic and experimental manipulation. Although several studies have described early lymphatic development in the fish, lymphatic development at later stages has not been completely elucidated. In this study, we generated a new Tg(mrc1a:egfp) y251 transgenic zebrafish that uses a mannose receptor, C type 1 (mrc1a) promoter to drive strong EGFP expression in lymphatic vessels at all stages of development and in adult zebrafish. We used this line to describe the assembly of the major vessels of the trunk lymphatic vascular network, including the later-developing collateral cardinal, spinal, superficial lateral and superficial intersegmental lymphatics. Our results show that major trunk lymphatic vessels are conserved in the zebrafish, and provide a thorough and complete description of trunk lymphatic vessel assembly.

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Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen

Cited by 40 publications

References 34 publications

Mannose Receptor Expression and Function Define a New Population of Murine Dendritic Cells

Mannose Receptor Expression and Function Define a New Population of Murine Dendritic Cells

New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment

Development of the larval lymphatic system in the zebrafish

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