Expression of Matrix Metalloproteinase 1( MMP1 ) in Hepatocellular Carcinoma ( HCC ) : Immunohistochemical and Biochemical Studies

Yassen, Mohy Eldin abdel Fattah abdel Atty; Hammam, Olfat; Sarhan, Hazem

doi:10.12816/0000845

Cited by 1 publication

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“…Also, the Child Pugh class B and C more increased in presence of T allele in homozygous and heterozygous forms (CT+TT) and PVT was more frequent in presence of T allele in homozygous and heterozygous forms (CT+TT). MMP-1 high expression proved to be a risk factor for tumor recurrence and independent molecular marker of prognosis in HCC and may become a novel target in the strategies for the prediction of tumor progression and prognosis of this disease (Yassen et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-11 Gene Polymorphisms as a Risk for Hepatocellular Carcinoma Development in Egyptian Patients

Saad

Zahran

Hendy

et al. 2020

Asian Pac J Cancer Prev

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Background: Chronic hepatitis C (CHC) virus infection is one of major risk factors of hepatocellular carcinoma (HCC) in Egypt, which is a major cause of cancer mortalityin the world. Matrix metalloproteinase-11 (MMP-11) has an important role in tumor migration and metastasis. Therefore, this study aimed to determine relation between MMP-11 gene polymorphisms and risk of HCC development among Egyptian cirrhotic patients. Subjects and methods: Two hundred and sixty patients were included, 140 of them with HCC on top of CHC and 120 patients with post CHC liver cirrhosis (LC) as well as 140 subjects were enrolled in the study as healthy controls. Two single nucleotide polymorphisms (SNPs) rs738791 and rs738792 for MMP-11 gene were done using real-time PCR. Results: Combination of CT and TT allele of rs738791 genotypes was more significantly frequent in HCC compared to LC patients and controls, however, a higher frequency of T allele was found in HCC patients compared to LC and controls. In spite of lake of significant difference between patient groups regarding the rs738792 genotypes, the CC genotype was considered a risk of developing portal vein thrombosis, and was associated with advanced tumor stage, increased tumor size, higher Cancer of the Liver Italian Program [CLIP] score, more advanced Barcelona stage [D] and with child Pugh class [C]. Conclusion: Genetic variations in MMP-11 may be implicated in post HCV-HCC development and might be dependable biomarkers for HCC progression.

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Section: Discussionmentioning

confidence: 99%