Expression of matrix metalloproteinase‐1, ‐7, ‐9, ‐13, Ki‐67, and HER‐2 in epithelial‐myoepithelial salivary gland cancer

Luukkaa, Heikki; Klemi, Pekka; Leivo, Ilmo; Mäkitie, Antti; Irish, Jonathan C.; Gilbert, Ralph W.; Perez-Ordonez, Bayardo; Hirsimäki, Pirkko; Vahlberg, Tero; Kivisaari, Atte; Kähäri, Veli‐Matti; Grénman, Reidar

doi:10.1002/hed.21277

Cited by 19 publications

(9 citation statements)

References 47 publications

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“…MMPs belong to an endopeptidase family dependent on zinc. This family is named due to its activity on ECM endopeptidase (24). MMP-2 and MMP-9 are important members of the family.…”

Section: Discussionmentioning

confidence: 99%

“…MMP-2 and MMP-9 can be expressed on a variety of cells, mainly consisting of inflammatory cells, mesenchymal cells in tumor tissues and tumor cells (25). Numerous studies have shown that MMP-2 and MMP-9 are overexpressed in the majority of human malignancies, which is associated with the infiltration and metastasis of tumor cells and prognosis of the patient (24,25). Previous studies have shown that MMP-2 and MMP-9 are also overexpressed in laryngocarcinoma tissue, and they are associated with lymphatic metastasis and poor prognosis (10) Studies show that the occurrence of laryngocarcinoma is associated with MAPK signal transduction.…”

Section: Discussionmentioning

confidence: 99%

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Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin�B1 and MMP‑9 and upregulation of p38‑MAPK signaling

et al. 2018

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The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesions. However, the efficacy of Ophiopogonin D on human laryngocarcinoma remains to be elucidated. The present study therefore investigated whether the anti-cancer effect of Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma. In the present study, it was found that Ophiopogonin D inhibited cell proliferation, promoted cytotoxicity, induced apoptosis and increased caspase-3/9 activity in human laryngocarcinoma cells. Ophiopogonin D significantly suppressed cyclin B1 and matrix metalloproteinase-9 (MMP-9) protein expression, and upregulated p-p38 MAPK protein expression in human laryngocarcinoma cells. Together, these results suggest Ophiopogonin D inhibits cell proliferation and induced apoptosis in human laryngocarcinoma cells through downregulation of cyclin B1 and MMP-9 and upregulation of the p38 MAPK signaling pathway. Therefore, Ophiopogonin D may be a potential therapy for the treatment of human laryngocarcinoma.

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“…MMPs belong to an endopeptidase family dependent on zinc. This family is named due to its activity on ECM endopeptidase (24). MMP-2 and MMP-9 are important members of the family.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin�B1 and MMP‑9 and upregulation of p38‑MAPK signaling

et al. 2018

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“…Although aggressive chemotherapy regimens have emerged, 30-50% of patients still die of pulmonary metastasis (Jaffe 2009;Geller & Gorlick 2010). During the last two decades, numerous studies have demonstrated a correlation between MMPs overexpression and the prognosis of various kinds of cancer, including hepatocellular carcinoma, salivary gland cancer and osteosarcoma (Luukkaa et al 2010;Korpi et al 2011;Ng et al 2011). As the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified (Hirotsu et al 2010;Yang et al 2010;Posthumadeboer et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…During the last two decades, numerous studies have demonstrated a correlation between MMPs overexpression and the prognosis of various kinds of cancer, including hepatocellular carcinoma, salivary gland cancer and osteosarcoma (Luukkaa et al 2010;Korpi et al 2011;Ng et al 2011). For example, MMP-2 overexpression was shown to be a poor prognosis for osteosarcoma patients (Wen et al 2013), and vascular endothelial growth factor (VEGF) overexpression in osteosarcoma patients indicated a poor prognosis as well .…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase 9 expression and survival of patients with osteosarcoma: a meta-analysis

Liu

Wang²,

Teng

et al. 2015

Eur J Cancer Care

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Several studies have evaluated the effect of matrix metalloproteinase-9 (MMP-9) expression on the overall survival of patients with osteosarcoma, but the results remain conflicting. To examine the prognostic significance of MMP-9 expression in osteosarcoma risk, we conducted this meta-analysis to systematically review the published studies. We searched the commonly used electronic databases updated to September 2013 for relevant studies which evaluated the correction between MMP-9 expression and survival of patients with osteosarcoma. Overall, a total of eight studies including 437 cases were screened out. No significant heterogeneity was observed between studies. The MMP-9 was expressed in 73.9% (323/437) of cases, and the results showed that MMP-9 expression was associated with increased mortality rate of osteosarcoma during the follow-up (risk ratio = 2.79, 95% confidence interval, CI = 1.96-3.97, P < 0.00001). By ethnicity analysis, a significant correction was also found between MMP-9 expression and osteosarcoma risk among Asian and non-Asian population (P < 0.001), indicating that MMP-9 was an indicator of prognosis of osteosarcoma. In conclusion, this meta-analysis indicated that MMP-9 expression might be a biomarker of poor prognosis for patients with osteosarcoma. However, the prognostic value of MMP-9 on survival of osteosarcoma patients still needs further large-scale trials to be clarified.

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“…For example, in salivary gland myoepithelial carcinoma, MMP-9 expression predicts a better overall survival, and in regional metastases of head and neck cancers, MMP9 gene expression was decreased [79, 146]. Similarly, the expression of MMP-9 is associated with a better outcome in breast- and colitis-associated carcinomas [147, 148].…”

Section: Discussionmentioning

confidence: 99%

Fluctuating Roles of Matrix Metalloproteinase‐9 in Oral Squamous Cell Carcinoma

Vilén

Salo

Sorsa

et al. 2013

The Scientific World Journal

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One hallmark of cancer is the degradation of the extracellular matrix (ECM), which is caused by proteinases. In oral cancers, matrix metalloproteinases (MMPs), especially MMP-9, are associated with this degradation. MMPs break down the ECM allowing cancer to spread; they also release various factors from their cryptic sites, including cytokines. These factors modulate cell behavior and enhance cancer progression by regulating angiogenesis, migration, proliferation, and invasion. The development of early metastases is typical for oral cancer, and increased MMP-9 expression is associated with a poor disease prognosis. However, many studies fail to relate MMP-9 expression with metastasis formation. Contrary to earlier models, recent studies show that MMP-9 plays a protective role in oral cancers. Therefore, the role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers.

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Expression of matrix metalloproteinase‐1, ‐7, ‐9, ‐13, Ki‐67, and HER‐2 in epithelial‐myoepithelial salivary gland cancer

Abstract: MMPs and Ki-67 may have prognostic impact in epithelial-myoepithelial carcinoma.

Cited by 19 publications

References 47 publications

Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin�B1 and MMP‑9 and upregulation of p38‑MAPK signaling

Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma through downregulation of cyclin�B1 and MMP‑9 and upregulation of p38‑MAPK signaling

Matrix metalloproteinase 9 expression and survival of patients with osteosarcoma: a meta-analysis

Fluctuating Roles of Matrix Metalloproteinase‐9 in Oral Squamous Cell Carcinoma

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