Expression of matrix metalloproteinase-1, -9, -13, and tissue inhibitor of metalloproteinases-1 in basal cell carcinomas of the eyelid

Zlatarova, Zornitsa; Softova, E.; Докова, Клара; Messmer, Elisabeth M.

doi:10.1007/s00417-011-1810-x

Cited by 9 publications

(16 citation statements)

References 33 publications

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“…Matrix metalloproteinase 13 is induced during metastasis of various cancers including squamous cell carcinomas of the head and neck and is associated with a poor clinical outcome. Thus, MMP13 may serve as a prognostic marker for tumor invasiveness …”

Section: Discussionmentioning

confidence: 99%

“…Thus, MMP13 may serve as a prognostic marker for tumor invasiveness. (30) This article focuses on the role of exosomes in cell-cell and cell-stroma interactions in facilitating the metastasis of NPC cells. As the molecular composition of exosomes closely reflects the specialized functions of the parental cells of origin, (13) we found MMP13 overexpressed in NPC exo (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Stromal cells within tumor play a vital role in malignant transformation progression of solid tumors (14) which respond to tumor cells by the induction of MMPs. (30) Furthermore, exosomes can also interact with stromal cells in the cancer microenvironment, thus impact on tumor cell proliferation, metastasis, and angiogenesis. (1,10,(31)(32)(33)(34) Our data further suggested that MMP13-carrying exosomes promote tumor progression through regulating stromal cells.…”

Section: Discussionmentioning

confidence: 99%

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Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis

et al. 2015

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Nasopharyngeal cancer (NPC) is an endemic type of head and neck cancer with a high rate of cervical lymph node metastasis. Metastasis is the major cause of death in NPC patients. Increasing evidence indicates that exosomes play a pivotal role in promoting cancer metastasis by enhancing angiogenesis and ECM degradation. Matrix metalloproteinase 13 is an important kind of matrix proteinase that is often overexpressed in various tumors and increases the risk of metastasis. However, little is known about the potential role of MMP13‐containing exosomes in NPC. In this study, we found that MMP13 was overexpressed in NPC cells and exosomes purified from conditioned medium (CM) as well as NPC patients’ plasma. Transwell analysis revealed that MMP13‐containing exosomes facilitated the metastasis of NPC cells. Furthermore, siRNA inhibited the effect of MMP13‐containing exosomes on tumor cells metastasis as well as angiogenesis. The current findings provided novel insight into the vital role of MMP13‐containing exosomes in NPC progression which might offer unique insights for potential therapeutic strategies for NPC progressions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis

et al. 2015

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“…MMP-1 is the primary collagenolytic enzyme in BCC and expressed at various intensities in epithelial tumour cells and surrounding stromal cells, including fibroblasts, inflammatory cells and vascular endothelial cells [157,158]. The expression of MMP-1 is significantly enhanced at the invasive front of BCC, suggesting its role in the initial steps of tumour proliferation; even when potentially important variables such as age and individual variability are controlled for, tumour-specific effects on the expression of MMP-9 and MMP-1 also need be taken into consideration [159].…”

Section: Collagenasesmentioning

confidence: 99%

“…Experimental models, mostly based on MMP-9 knockout mice, have provided unequivocable evidences about the pivotal role played by the enzyme in tumour growth, invasiveness and angiogenesis [61]. MMP-9 prominently expressed at the invading edge of the BCC and was mostly secreted by inflammatory cells, such as macrophages, rather than by tumour cells [158,168]. Odds ratio for development of morpheaform and recurrent BCC was 5.8 for positive MMP-9 immunostaining in tumour stroma, suggesting MMP-9 expression in stromal cells is associated with morpheaform and recurrent BCC [161].…”

Section: Gelatinasesmentioning

confidence: 99%

Skin Ageing and Cancer

Zhang¹,

Wang²,

Wang³

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26) and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24 and MMP-25). MMPs can act on extracellular matrix (ECM) and non-ECM components affecting degradation and modulation of the ECM, growth-factor activation and cell-cell and cell-matrix signalling. In skin, MMPs are secreted by different cell types such as fibroblasts, keratinocytes, macrophages, endothelial cells, mast cells, and eosinophils. This chapter reviews the role of MMPs in maintaining skin homeostasis, skin ageing and skin cancer.

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Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma

et al. 2016

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The aim of this study was to compare the expressions of mRNA for metalloproteinases (MMP-2 and MMP-9) and type IV collagen in two different histological types of basal-cell carcinoma (BCCs; nodular and infiltrative) and in normal tissues from the tumor interface. The study included biopsy specimens of the skin involved with BCC and normal skin adjacent the lesion. The expressions of mRNA for MMP-2, MMP-9 and type IV collagen were determined by means of RT-PCR (Reverse transcription polymerase chain reaction). The level of type IV collagen mRNA in nodular and infiltrative BCCs turned out to be significantly lower, and the expressions of MMP-2 and MMP-9 mRNA significantly higher than in normal tissues adjacent to these tumors. The expression of mRNA for MMP-9 but not for MMP-2 was significantly higher in infiltrative BCCs than in the nodular BCCs. In turn, normal tissues adjacent to nodular BCCs showed significantly higher levels of mRNA for MMP-2 and significantly lower levels of type IV collagen mRNA than the normal tissues from the interface of infiltrative BCCs. The findings suggest that MMP-2 and MMP-9 could be used as prognostic factors of BCCs.

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Expression of matrix metalloproteinase-1, -9, -13, and tissue inhibitor of metalloproteinases-1 in basal cell carcinomas of the eyelid

Abstract: MMP-9, MMP-13 and TIMP-1 expression may serve as a prognostic marker for early tumor invasiveness. Moreover, up-regulation of TIMP-1 in tumor and/or surrounding stromal cells may indicate an increased risk for BCC recurrence.

Cited by 9 publications

References 33 publications

Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis

Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis

Skin Ageing and Cancer

Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma

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