Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement

Suminoe, Aiko; Matsuzaki, Akinobu; Hattori, Hiroyoshi; Koga, Yuhki; Ishii, Eiichi; Hara, Toshiro

doi:10.1016/j.leukres.2007.01.015

Cited by 45 publications

(29 citation statements)

References 8 publications

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“…Increased MMP-9 activity after hyperoxia has been linked to later BPD development (30). There is also an increasing body of research showing that MMPs, and specifically MMP-2 and MMP-9, are involved in tumor growth and metastasis and may have a role in acute lymphoblastic leukemia (ALL) (31,32).…”

Section: Discussionmentioning

confidence: 99%

Resuscitation of Hypoxic Newborn Piglets With Supplementary Oxygen Induces Dose-Dependent Increase in Matrix Metalloproteinase-Activity and Down-Regulates Vital Genes

et al. 2010

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ABSTRACT:The optimal oxygen concentration for newborn resuscitation is still discussed. Oxygen administration during reoxygenation may induce short-and long-term pathologic changes via oxidative stress and has been associated to later childhood cancer. The aim was to study changes in oxidative stress-associated markers in liver and lung tissue of newborn pigs after acute hypoxia followed by reoxygenation for 30 min with 21, 40, or 100% oxygen compared with room air or to ventilation with 100% oxygen without preceding hypoxia. Nine hours after resuscitation, we found a dose-dependent increase in the matrix metalloproteinase gelatinase activity in liver tissue related to percentage oxygen supply by resuscitation (100% versus 21%; p ϭ 0.002) pointing at more extensive tissue damage. Receiving 100% oxygen for 30 min without preceding hypoxia decreased the expression of VEGFR2 and TGFBR3 mRNA in liver tissue, but not in lung tissue. MMP-, VEGF-, and TGF␤-superfamily are vital for the development, growth, and functional integrity of most tissues and our data rise concern about both short-and longterm consequences of even a brief hyperoxic exposure. O ver the last two decades, the traditionally recommended use of 100% oxygen for newborn resuscitation has been extensively challenged. Meta-analyses have shown room air to be as efficient as 100% oxygen and that 100% oxygen increases both mortality and morbidity (1-3). In addition, an association has been found between newborn resuscitation with 100% oxygen and later childhood cancer (4,5) pointing at the outmost necessity to search for the underlying cause.Perinatal asphyxia may induce hypoxia-reoxygenation (HR) injury to various organs including liver and lungs, which have important roles in host defense after both organic and inorganic environmental insults (6). Liver-tissue responses to potentially damaging neonatal hypoxia and reoxygenation are of particular interest because of the unique and remarkable capacity of this organ to regenerate after injury via DNA replication and mitosis (7). The lungs are in a direct and continuous communication with the outside environment and are exposed directly to the highest partial pressure of inspired O 2. The time course of reactive oxygen species (ROS) generation during hypoxia and reperfusion is not clearly understood (8), but experimental evidence indicates a worsening of the hypoxic injury by reoxygenation (9,10). The underlying mechanisms of hypoxia induced liver or lung injury, and the nature of the detrimental biofactors set in motion these circumstances, are still poorly understood. Among the molecules whose expression and activity are modulated in tissue damage and repair are the matrix metalloproteinases (MMPs). MMPs belong to a family of zinc-containing endopeptidases best known for their roles in the physiologic and pathologic remodeling of the extracellular matrix (ECM) during angiogenesis, embryogenesis, wound healing, tumor metastasis, and various cardiovascular and inflammatory diseases (11). MMPs are important in...

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Section: Discussionmentioning

confidence: 99%

Resuscitation of Hypoxic Newborn Piglets With Supplementary Oxygen Induces Dose-Dependent Increase in Matrix Metalloproteinase-Activity and Down-Regulates Vital Genes

et al. 2010

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“…20,23) Therefore, overexpression of TIMPs may inhibit cancer cell growth and metastasis in various cancers. 24) In the present study, we determined the antimetastatic effect of laver extract in SK-Hep1 cells using migration and invasion assays. We also investigated the relationship of MMP-2/-9 and TIMP-1/-2 expression at both the protein and the gene level in SK-Hep1 human hepatoma carcinoma cells after laver extract treatment.…”

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confidence: 99%

Effects of laver extracts on adhesion, invasion, and migration in SK-Hep1 human hepatoma cancer cells

Thi

Hwang

2014

Bioscience, Biotechnology, and Biochemistry

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The laver (Porphyra tenera), red seaweed, has been reported to have anticancer activity, but little is known about its molecular mechanisms of action. The objective of this study was to determine the effects of laver extract on cancer cell proliferation, invasion, and metastasis in SK-Hep1 cells using migration and invasion assays. We also investigated the relationship of MMP-2/-9 and TIMP-1/-2 expression at both the protein and gene level in SK-Hep1 human hepatoma carcinoma cells after laver extract treatment. Laver extract inhibited cancer cell growth in a dose-dependent manner. In an invasion assay conducted in Transwell chambers, laver extract showed 19.6 and 27.2% inhibition of cancer cell at 200 and 400 μg/mL, respectively, compared to the control. The mRNA levels of both MMP-2 and MMP-9 were down-regulated by laver extract treatment in a dose-dependent manner. Laver extract, at 400 μg/mL, was inhibited by MMP-2 and MMP-9 expressions by 70.1 and 77.0%, respectively. An inverse relationship in the mRNA contents of MMP-2/-9 and TIMP-1/-2 expressions in SK-Hep1 cells was found by laver extract treatment. Our results demonstrate antimetastatic properties of laver extract in inhibiting the adhesion, invasion, and migration of SK-Hep1 human hepatoma cancer cells.

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“…3,4 The active processes of leukemic cell migration are accomplished via the catalytic activities of matrix metalloproteinases (MMPs), which allow the cells to penetrate stromal tissues and blood vessel barriers. 5,6 In addition to the role in leukemia cell movement, MMPs are believed to be central for angiogenesis in the microenvironment of the BM of leukemia patients.…”

mentioning

confidence: 99%

Enhanced invasiveness of drug‐resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase‐2

Song

Kim

Cho

et al. 2009

Intl Journal of Cancer

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The acquired drug resistance as well as extramedullary tissue infiltration of leukemic cells is a major obstacle in leukemia treatment. Excessive egress of leukemia cell blasts results in invasion into various organs or tissues, which is facilitated by the catalytic activities of matrix metalloproteinases (MMPs). However, the migration of chemoresistant leukemia cells remains unclear. Here, we generated drug-resistant variants of the human acute myeloid leukemia cell line (AML-2/WT) by stepwise exposure to anticancer drugs and evaluated the level of MMP-2 in the drug-resistant variants, along with their invasiveness. Each of the drug-resistant cell variants demonstrated predominant increases in the expression and gelatinolytic activity of MMP-2 as well as in invasiveness, which were significantly suppressed by both a MMP-2 inhibitor and a blocking antibody. Knockdown experiments using MMP-2 short hairpin RNA also indicated that its upregulation was strongly associated with the cells' increased invasive properties. Importantly, elevated levels of MMP-2 activity and invasiveness were observed in ex vivo mononuclear cell of bone marrow from patients with poor responses to chemotherapy. These findings suggest that advanced malignancy due to acquired drug resistance is responsible for the progressive invasiveness of leukemia cells via MMP-2. ' 2009 UICC

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Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement

Cited by 45 publications

References 8 publications

Resuscitation of Hypoxic Newborn Piglets With Supplementary Oxygen Induces Dose-Dependent Increase in Matrix Metalloproteinase-Activity and Down-Regulates Vital Genes

Resuscitation of Hypoxic Newborn Piglets With Supplementary Oxygen Induces Dose-Dependent Increase in Matrix Metalloproteinase-Activity and Down-Regulates Vital Genes

Effects of laver extracts on adhesion, invasion, and migration in SK-Hep1 human hepatoma cancer cells

Enhanced invasiveness of drug‐resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase‐2

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