Expression of microRNA‑184 in glioma

Wu, Xiaoben; Wu, Yang; Fan, Gang; Lin, Wanrun; Liu, Fang; Lu, Zhiming

doi:10.3892/ol.2017.7395

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…The rno‐miR‐184 has dual functions in cancers. It is an onco‐miRNA in osteosarcoma (Du, Li, Wang, Huang, & Xu, ), squamous cell carcinoma of tongue (Wong et al, ), but acts as a tumour suppressor in colorectal cancer (Wu, Liu, Wu, Wu, & Yao, ), breast cancer (Fu et al, ), even acts as both onco‐miRNA (Wu et al, ) and suppressor miRNA in glioma (Cheng et al, ). Although rno‐miR‐184 is an onco‐miRNA in prostate cancer (Lin, Chiang, Chang, & Ying, ; Walter, Valera, Pinto, & Merino, ), there is no evidence about relationship between rno‐miR‐184 and BPH.…”

Section: Discussionmentioning

confidence: 99%

Regulation of microRNAs by rape bee pollen on benign prostate hyperplasia in rats

Chen¹,

Wu²,

Ren³

et al. 2019

Andrologia

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The miRNAs are dysregulated in BPH. Rape bee pollen (RBP) is used to improve benign prostatic hyperplasia (BPH). Whether RBP treats BPH by regulating the dysregulated miRNAs remains unclear. Here, we identified miRNAs regulated along with the improvement of BPH by RBP in posterior lobes of prostate in rats. Firstly, to screened miRNAs might relate to improvement of BPH by RBP, we compared differentially expressed miRNAs between BPH model group and RBP group by highthroughput sequencing. As a result, 10 known miRNAs and 17 novel miRNA were up-regulated in RBP group, and 6 known and 13 novel miRNAs were down-regulated. Secondly, among the known miRNAs, we identified those that might relate to BPH by RT-qPCR, while only rno-miR-184 was screened, so we compared it among normal control group, BPH model group and RBP group. The results showed that rno-miR-184 was significantly lower expressed in BPH group, but up-regulated along with the improvement of BPH by RBP. Moreover, expression level of rno- miR-184 was no difference between RBP group and normal control level. Therefore, we considered that RBP might improve BPH through regulating expression of miRNAs like rno-miR-184 in prostate in rats. K E Y W O R D Sbenign prostatic hyperplasia, miRNAs, rape bee pollen, rat, RNA-Seq

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Section: Discussionmentioning

confidence: 99%

Regulation of microRNAs by rape bee pollen on benign prostate hyperplasia in rats

Chen¹,

Wu²,

Ren³

et al. 2019

Andrologia

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“…Indeed, MicroRNA 184 was also described as significantly downregulated in tissues from patients with colorectal cancer, ovarian cancer or prostate carcinoma, compared with matched normal adjacent tissues [ 38 , 81 , 82 ]. It was also differentially expressed in glioma tissues compared to normal brain tissues [ 83 ], and in tongue carcinomas tissues compared to paired normal tissues [ 84 ]. Micro-RNA-196 was differentially expressed in pancreatic resection specimens from carcinoma cases and its precursors vs. benign pancreatic specimens [ 85 ], in oral squamous cell carcinoma tissues (OSCC) vs. contral mucosa [ 86 ], in breast cancer samples vs. normal breast samples [ 87 ] and in colonic cancer specimens vs. para-cancerous specimens [ 88 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of micro-RNA expression profile related to recurrence in women with ESMO low-risk endometrial cancer

et al. 2018

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BackgroundActual European pathological classification of early-stage endometrial cancer (EC) may show insufficient accuracy to precisely stratify recurrence risk, leading to potential over or under treatment. Micro-RNAs are post-transcriptional regulators involved in carcinogenic mechanisms, with some micro-RNA patterns of expression associated with EC characteristics and prognosis. We previously demonstrated that downregulation of micro-RNA-184 was associated with lymph node involvement in low-risk EC (LREC). The aim of this study was to evaluate whether micro-RNA signature in tumor tissues from LREC women can be correlated with the occurrence of recurrences.MethodsMicroRNA expression was assessed by chip analysis and qRT-PCR in 7 formalin-fixed paraffin-embedded (FFPE) LREC primary tumors from women whose follow up showed recurrences (R+) and in 14 FFPE LREC primary tumors from women whose follow up did not show any recurrence (R−), matched for grade and age. Various statistical analyses, including enrichment analysis and a minimum p-value approach, were performed.ResultsThe expression levels of micro-RNAs-184, -497-5p, and -196b-3p were significantly lower in R+ compared to R− women. Women with a micro-RNA-184 fold change < 0.083 were more likely to show recurrence (n = 6; 66%) compared to those with a micro-RNA-184 fold change > 0.083 (n = 1; 8%), p = 0.016. Women with a micro-RNA-196 fold change < 0.56 were more likely to show recurrence (n = 5; 100%) compared to those with a micro-RNA-196 fold change > 0.56 (n = 2; 13%), p = 0.001.ConclusionsThese findings confirm the great interest of micro-RNA-184 as a prognostic tool to improve the management of LREC women.

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“…US National Science Foundation provided excellent logistic support to the South Pole-based experiments. Currently, the BICEP3 telescope [25], Keck Array [26], and the 10 m South Pole Telescope (SPT) [27] are observing from the South Pole at mm-wave bands.…”

Section: South Polementioning

confidence: 99%

Assessments of Ali, Dome A, and Summit Camp for mm-wave Observations Using MERRA-2 Reanalysis

Kuo

2017

ApJ

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NASA's latest MERRA-2 reanalysis of the modern satellite measurements provides unprecedented uniformity and fidelity for the atmospheric data. In this paper, these data are used to evaluate five sites for millimeter-wave (mm-wave) observations. These include two established sites (South Pole and Chajnantor, Atacama), and three new sites (Ali, Tibet; Dome A, Antarctica; and Summit Camp, Greenland). Atmospheric properties including precipitable water vapor (PWV), sky brightness temperature fluctuations, ice and liquid water paths are derived and compared. Dome A emerges to be the best among those evaluated, with PWV and fluctuations smaller than the second-best site, South Pole, by more than a factor of 2. It is found that the higher site in Ali (6,100 m) is on par with Cerro Chajnantor (5,612 m) in terms of transmission and stability. The lower site in Ali (5,250 m) planned for first stage of observations at 90/150GHz provides conditions comparable to those on the Chajnantor Plateau. These analyses confirm Ali to be an excellent mm-wave site on the Northern Hemisphere that will complement well-established sites on the Southern Hemisphere. It is also found in this analysis that the observing conditions at Summit Camp are comparable to Cerro Chajnantor. Although it is more affected by the presence of liquid water clouds.

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Expression of microRNA‑184 in glioma

Cited by 5 publications

References 18 publications

Regulation of microRNAs by rape bee pollen on benign prostate hyperplasia in rats

Regulation of microRNAs by rape bee pollen on benign prostate hyperplasia in rats

Identification of micro-RNA expression profile related to recurrence in women with ESMO low-risk endometrial cancer

Assessments of Ali, Dome A, and Summit Camp for mm-wave Observations Using MERRA-2 Reanalysis

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