Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium

Buchynska, L G; Borykun, T V; Iurchenko, N P; Nespryadko, S V; Nesina, I P

doi:10.32471/exp-oncology.2312-8852.vol-42-no-4.15522

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…In EC, miR-125b-5p acts as a tumor suppressor miRNA and inhibits invasion of EC cells by directly targeting protooncogene ERBB2 28 . However, the expression of miR-125b-5p was not correlated with patients' survival, even though the decreased level of miR-125b-5p was found to be associated with higher histological grade and myometrial invasion 29 .…”

Section: Discussionmentioning

confidence: 85%

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

Włodarski

Klicka

Grzywa

et al. 2022

Preprint

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Endometrial cancer (EC) is one of the most common types of cancer of the female reproductive system. EC is classified into two types (EC1 and EC2). MiRNAs are single-stranded RNA molecules that regulate gene expression posttranscriptionally. They have aberrant expression profiles in cancer, including EC. This study aimed to assess the level of expression of a panel of 16 miRNAs in both types of EC and healthy endometrium (HE). A total of 45 patients were enrolled into the study, 18 patients diagnosed with EC1, 12 diagnosed with EC2, and 15 HE controls. Tumor tissues or healthy endometrial tissues were dissected from archival formalin-fixed paraffin-embedded (FFPE) using laser capture microdissection (LCM). RNA was isolated from collected material and the expression of selected miRNAs was determined using the real-time qPCR. We found that miR-23b, miR-125b-5p, miR-199a-3p, miR-221-3p, and miR-451a were downregulated in EC in comparison to HE. Moreover, the expression of miR-34a-5p and miR-146-5p was higher in EC1 compared to EC2. Analysis of The Cancer Genome Atlas (TCGA) database confirmed decreased levels of miR-23b, miR-125b-5p, and miR-199a-3p in EC. Decreased miR-23b expression was associated with worse survival of EC patients.

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Section: Discussionmentioning

confidence: 85%

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

Włodarski

Klicka

Grzywa

et al. 2022

Preprint

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“…Further, we collected data from articles investigating the association between the expression of invasion-related miRNAs in tumor tissue and clinical parameters, including OS, DFS, PFS, FIGO stage, histological grade, myometrial invasion, and lymph node metastases. We identified 51 articles that correlated upregulated expression of 25 miRNAs and downregulated expression of 41 miRNAs with at least one clinical parameter ( Table 4 ) [ 18 , 19 , 24 , 25 , 28 , 29 , 32 , 34 , 37 , 38 , 41 , 44 , 49 , 51 , 52 , 56 , 57 , 58 , 60 , 69 , 70 , 71 , 76 , 77 , 78 , 79 , 81 , 84 , 95 , 99 , 100 , 108 , 110 , 111 , 115 , 117 , 120 , 122 , 130 , 131 , 132 , 147 , 154 , 160 , 175 , 176 , 177 , 178 , …”

Section: Resultsmentioning

confidence: 99%

“…)[18,19,24,25,28,29,32,34,37,38,41,44,49,51,52,[56][57][58]60,[69][70][71][76][77][78][79]81,84,95,99,100,108,110,111,115,117,120,122,[130][131][132]147,154,160,[175][176][177][178][179][180][181]. The correlation of miRNA expression and clinical parameters.…”

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confidence: 99%

The Role of miRNAs in the Regulation of Endometrial Cancer Invasiveness and Metastasis—A Systematic Review

Klicka

Grzywa

Klinke

et al. 2021

Cancers

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Endometrial cancer (EC) is the most common genital cancer in women with increasing death rates. MiRNAs are short non-coding RNAs that regulate gene expression on the post-transcriptional levels. Multiple studies demonstrated a fundamental role of miRNAs in the regulation of carcinogenesis. This systematic review is a comprehensive overview of the role of miRNAs in the regulation of cancer cell invasiveness and metastasis in EC. The literature was searched for studies investigating the role of miRNAs in the regulation of invasiveness and metastasis in EC. We explored PubMed, Embase, and Scopus using the following keywords: miRNA, metastasis, invasiveness, endometrial cancer. Data were collected from 163 articles that described the expression and role of 106 miRNAs in the regulation of EC invasiveness and metastasis out of which 63 were tumor suppressor miRNAs, and 38 were oncomiRNAs. Five miRNAs had a discordant role in different studies. Moreover, we identified 66 miRNAs whose expression in tumor tissue or concentration in serum correlated with at least one clinical parameter. These findings suggest a crucial role of miRNAs in the regulation of EC invasiveness and metastasis and present them as potential prognostic factors for patients with EC.

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“…Endometrial carcinoma (EC) is an epithelial malignancy that occurs in the endometrium of women, which is classified into mucinous adenocarcinoma, endometrioid adenocarcinoma, papillary serous endometrial adenocarcinoma, adenocarcinoma with squamous cell differentiation, squamous carcinoma, and clear cell carcinoma [ 1 , 2 ]. Relevant literature has pointed out that EC is one of the malignant tumors with high incidence worldwide, accounting for approximately 25% of malignant diseases of the female reproductive system [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Pelvic Magnetic Resonance Imaging Scan Combined with Serum Pyruvate Kinase Isozyme M2, Neutrophil Gelatinase‐Associated Lipocalin, and Soluble Leptin Receptor Detection in Diagnosing Endometrial Carcinoma

Yin

2022

Contrast Media & Molecular Imaging

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Objective. To explore the application value of pelvic magnetic resonance imaging (MRI) scan combined with serum pyruvate kinase isozyme M2 (PKM2), neutrophil gelatinase-associated lipocalin (NGAL), and soluble leptin receptor (sOB-R) detection in diagnosing endometrial carcinoma (EC). Methods. The clinical data of 45 patients with pathologically confirmed EC treated in our hospital from May 2019 to May 2020 were retrospectively analyzed. All patients received pelvic MRI scan, serum PKM2, NGAL and sOB-R detection was performed, and the combination of the two was performed so as to analyze the diagnostic application value of the three modalities. Results. Compared with the joint detection, the number of true positive cases, sensitivity, specificity, and accuracy rate obtained by a single application of pelvic MRI or serum PKM2, NGAL, and sOB-R detection were obviously lower; the area under the ROC curve of the joint detection was obviously larger than that of single detection; the results of the joint detection were better than those of single detection ( P < 0.05 ); the combined diagnosis obtained the highest sensitivity. Conclusion. Combining pelvic MRI with serum PKM2, NGAL, and sOB-4 detection can effectively promote the diagnostic accuracy for EC, presenting significant clinical diagnostic value.

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Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium

Cited by 9 publications

References 7 publications

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

The Role of miRNAs in the Regulation of Endometrial Cancer Invasiveness and Metastasis—A Systematic Review

Application of Pelvic Magnetic Resonance Imaging Scan Combined with Serum Pyruvate Kinase Isozyme M2, Neutrophil Gelatinase‐Associated Lipocalin, and Soluble Leptin Receptor Detection in Diagnosing Endometrial Carcinoma

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