2010
DOI: 10.1007/s10517-010-1100-3
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Expression of Mitochondrial Uncoupling Protein UCP2 in the Brain of Rats after Hippocampal Injury Inflicted by Kainic Acid

Abstract: The expression of mitochondrial protein UCP2 and cytochrome C-oxidase subunit III genes in the hippocampus and prefrontal cortex was evaluated by real-time PCR 3 and 7 days after microinjection of kainic acid into the dorsal hippocampus. In contrast to cytochrome C-oxidase subunit III mRNA, the level of UCP2 mRNA in the hippocampus increased 1 week after microinjection of kainic acid. The expression of both genes in the prefrontal cortex did not differ from the control. Presumably, activation of UCP2 synthesis… Show more

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Cited by 6 publications
(2 citation statements)
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“…To this end, we observed increased expression of UCP2 after pilocarpine administration in the silent phase, reaching a peak on the fifth day after status epilepticus onset. This is corroborated by groups who analyzed kainic acid-induced epilepsy in rodents [ 43 , 45 , 46 ].…”
Section: Discussionsupporting
confidence: 64%
“…To this end, we observed increased expression of UCP2 after pilocarpine administration in the silent phase, reaching a peak on the fifth day after status epilepticus onset. This is corroborated by groups who analyzed kainic acid-induced epilepsy in rodents [ 43 , 45 , 46 ].…”
Section: Discussionsupporting
confidence: 64%
“…Kainic acid has been shown to significantly upregulate UCP2 mRNA expression with the peak level at 24 h and returning to basal levels within 72 h after injection [30]. Lebedev and Arkhipov reported an increase in the level of UCP2 mRNA in the hippocampus one week after microinjection of kainic acid [31]. SOD2 is one of the most important antioxidative stress proteins.…”
Section: Discussionmentioning
confidence: 99%