Expression of MMPs/TIMP in endometriosis

Li, Y.; Wang, L.; Tian, Fang; Xiao, Fengjun; Xu, Dan; Yu, Zhiwen

doi:10.1016/s0015-0282(01)03111-9

Cited by 2 publications

(2 citation statements)

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“…ARID1A wt and ARID1A mut tumors had significant differences in the collagen content and structure. Matrix metallopeptidases (MMP) mediate endometrial breakdown at menstruation, and the regulation of MMPs and their inhibitors allows for ectopic endometriosis to invade other tissues by remodeling the ECM ( 44 ). We hypothesize that CCOC emerging from endometriosis has a very different collagen matrix to CCOC that does not arise from endometriosis, due to the actions of MMPs and related molecules.…”

Section: Discussionmentioning

confidence: 99%

The Tumor Microenvironment of Clear-Cell Ovarian Cancer

Devlin

Miller

Laforets

et al. 2022

Cancer Immunology Research

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Some patients with advanced clear cell ovarian cancer (CCOC) respond to immunotherapy; however, little is known about the tumor microenvironment (TME) of this relatively rare disease. Here, we describe a comprehensive quantitative and topographical analysis of biopsies from forty-five patients, nine with FIGO stage I/II (early CCOC) and thirty-six with FIGO stage III/IV (advanced CCOC). We investigated fourteen immune cell phenotype markers, PD-1 and ligands, and collagen structure and texture. We interrogated a microarray dataset from a second cohort of twenty-nine patients and compared the TMEs of ARID1A-wildtype (ARID1Awt) versus ARID1A-mutant (ARID1Amut) disease. We found significant variations in immune cell frequency and phenotype, checkpoint expression, and collagen matrix between the malignant cell area (MCA), leading edge (LE), and stroma. The MCA had the largest population of CD138+ plasma cells, the LE had more CD20+ B cells and T cells, whereas the stroma had more mast cells and αSMA+ fibroblasts. PD-L2 was expressed predominantly on malignant cells and was the dominant PD-1 ligand. Compared to early-CCOC, advanced-stage disease had significantly more fibroblasts and a more complex collagen matrix, with microarray analysis indicating “TGFβ remodeling of the extracellular matrix” as the most significantly enriched pathway. Data showed significant differences in immune cell populations, collagen matrix, and cytokine expression between ARID1Awt and ARID1Amut CCOC, which may reflect different paths of tumorigenesis and the relationship to endometriosis. Increased infiltration of CD8+ T cells within the MCA and CD4+ T cells at the LE and stroma significantly associated with decreased overall survival.

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Section: Discussionmentioning

confidence: 99%

The Tumor Microenvironment of Clear-Cell Ovarian Cancer

Devlin

Miller

Laforets

et al. 2022

Cancer Immunology Research

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“…However, there remain controversial results, such as those of Li et al (24), whose observation suggests that the expression of MMP-2 was similar in the eutopic endometrium of women with and without endometriosis, and those of Gescher et al (25), who reported that the expression of VEGF in the endometrial fragments of women with endometriosis and in control women displayed little difference of significance. Those experiments support our findings of similar expression of MMP-2 and VEGF in eutopic endometrium of women with and without endometriosis.…”

Section: Lu Vegf and Mmp-2 Expedite Formation Of Endometriosis Fertmentioning

confidence: 97%

Vascular endothelial growth factor and matrix metalloproteinase-2 expedite formation of endometriosis in the early stage ICR mouse model

Ning

Dong

et al. 2006

Fertility and Sterility

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Expression of MMPs/TIMP in endometriosis

Cited by 2 publications

References 0 publications

The Tumor Microenvironment of Clear-Cell Ovarian Cancer

The Tumor Microenvironment of Clear-Cell Ovarian Cancer

Vascular endothelial growth factor and matrix metalloproteinase-2 expedite formation of endometriosis in the early stage ICR mouse model

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