Expression of moesin and CD44 is associated with poor prognosis in gastric adenocarcinoma

Abstract

Moesin expression and CD44 expression might be useful markers of poor prognosis in gastric adenocarcinoma.

The Prognostic Value of CD44 Expression in Epithelial–Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer

“…This finding is contrary to that of Jung et al who demonstrated significant differences only in highly expressing CD44 patients and overall survival using KaplanMeier curves and independently of pathological TNM stage and histological grade (28).…”

“…Interaction between moesin and CD44 is known to be an important process in the EMT of tumor cells (20,27). Nevertheless, Jung et al demonstrated that the expression of CD44 was an independent indicator of poor prognosis but was not correlated with other clinicopathological factors, nor with moesin expression (28).…”

Autophagy regulates cisplatin‐induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma

“…15,16 Moreover, CD44 may also symbolize a potential marker of OSCC stem cells. 17,18 This study confirms the expression of stem cell surface marker CD44 expression in OSCC tissue samples.…”

Molecular Mechanisms in Gastric Carcinogenesis

“…This phenotype has been observed in CSC derived from prostate, breast, pancreatic, and gastric tumors [17]. Interestingly, CD44 overexpression has been associated with poor prognosis and reduced overall survival in GC [107]. CD44 is a cell surface receptor, which mediates interaction with ECM component, particularly HA [107].…”