Expression of mouse PDGF-A and PDGF α-receptor genes during pre- and post-implantation development: Evidence for a developmental shift from an autocrine to a paracrine mode of action

Palmieri, Susan L.; Payne, Jennifer; Stiles, Charles D.; Biggers, John D.; Mercola, Mark

doi:10.1016/0925-4773(92)90045-l

Cited by 66 publications

(37 citation statements)

References 39 publications

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“…One example of this overlap is the expression of the PDGF a receptor in the somites and the head mesenchyme at day 8 p.c. (Palmieri et al, 1992). The reason for this apparant redundancy could be that different cells need different sets of genes regulating proliferation, migration, and differentiation during embryonic development.…”

Section: -Dmentioning

confidence: 99%

Expression of M‐twist during postimplantation development of the mouse

Füchtbauer

1995

Developmental Dynamics

158

101

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The murine homologue of the Drosophila twist gene has been shown to be essential for head mesenchyme formation and to act as an inhibitor of muscle differentiation. This paper presents a detailed analysis of M-twist expression patterns from day 7 post coitum ( p . 4 to day 18 P.c., indicating a more general function of the M-twist gene. At day 7 P.c., M-twist is expressed in the mesoderm outside the primitive streak. Later M-twist message is predominantly found in the somites, the head mesenchyme, the branchial arches, the limbs, and in the mesenchyme underneath the epidermis. Beginning at day 8 P.c., M-twist is mainly expressed in undifferentiated cells committed to muscle and cartilage development: this expression is consistent with a suggested role of M-twist in inhibiting overt muscle and cartilage differentiation. However, during organogenesis, M-twist is expressed in several areas of mesenchyme-epithelia interactions, suggesting additional tissue specific functions. 0 1995 Wiley-Liss, Jnc.

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Section: -Dmentioning

confidence: 99%

Expression of M‐twist during postimplantation development of the mouse

Füchtbauer

1995

Developmental Dynamics

158

101

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“…The relevant ligand in mouse could be embryo-derived TGFa since the corresponding mRNA (like the EGFreceptor mRNA) is found in increasing concentrations which reach high levels at the blastocyst stage. The TGFa protein is also detectable by the blastocyst stage [Rappolee et al, 19881 and is located mainly on the ICM and polar trophectoderm cells [Dardik et al, 19921. Since the ligand can create a developmental signal only after binding to the EGF-receptor, various assays have been used t o demonstrate the occurrence of the receptor on the surface of embryo cells ( Wiley et al, Wiley et al, 1992Dardik et al, 1992Mattson et al, 1988Heyner et al, 1989 Rosenblum et al, 1986 Harvey and Kaye, 1991h Rappolee et al, 1990Rappolee et al, , 1992 Rappolee et al, 1990 Rappolee et al, 1990Rappolee et al, , 1992 Schultz et al, 1993Schultz et al, 1993Palmieri et al, 1992a Paria et al, 1992…”

Section: Egf and Egf-receptor Families Of Genes: Their Activities In mentioning

confidence: 99%

“…Several types of growth factors can influence preimplantation development in vitro, but this merely illustrates the presence of an active receptor rather than the necessity for the growth factor for development. Cytokines are involved in the latter stages of the pre-or peri-implantation embryo as the embryo meets the challenge of the mother's Rappolee et al, 1988Rappolee et al, 1988Dardik et al, 1992Rappolee et al, 1988Rappolee et al, 1988Rappolee et al, 1988Rappolee et al, 1990Rappolee et al, 1990Rizzino, 1985Rappolee et al, 1990Rappolee et al, 1990Rappolee et al, 1990Rappolee et al, 1992Rappolee et al, 1988Rappolee et al, 1988Paria et al, 1992Palmieri et al, 1992aPalmieri et al, 1992aPalmieri et al, 1992a Murray et al, Murray et al, 1990 immune system. Studies such as these are the focus of this essay.…”

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confidence: 99%

“…Rappolee et al Rizzino and Bowen-Pope, 1985Palmieri et al, 1992aParia and Dey, 1990Slager et al, 1993Tartakovsky and Ben-Yair, 1991Tartakovsky and Ben-Yair, 1991 is known that the membrane proteins of the apical surface of an epithelial layer become less laterally mobile after the formation of tight junctions. The EGF-receptors could contribute to the polarization of the outer blastomeres by their inability to move to all cell surfaces after the formation of tight junctions.…”

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confidence: 99%

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Activities of growth factors in preimplantation embryos

Adamson

1993

J of Cellular Biochemistry

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The development of the mammalian preimplantation embryo in vitro occurs more slowly and less successfully compared to development in the uterus. The fact that it can occur at all in a defined protein-free medium suggests that the process is autonomous. Accumulated evidence indicates that a number of peptide growth facto-s contribute in an autocrine fashion to preimplantation development. Other growth factors are maternally derived and act in a paracrine manner on the embryo. Some of these factors such as insulin-related factors stimulate growth preferentially, but others such as epidermal growth factor (EGF) play more important roles in differentiation. Several cytokines appear to be implicated in peri-implantation events and in maternal-fetal interactions. At this stage, the data are mostly descriptive. Are all these different growth factors and receptors necessary for early development? Some implications of apparent redundancy of gene expression are discussed and future studies are predicted.

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“…PDGF-AA and the ␣PDGFR are coexpressed in preimplantation embryos, and following postimplantation, their expression becomes confined to separate regions of the embryo (41). These observations suggest that PDGF-AA drives certain events during embryogenesis, and also that there is a shift from an autocrine to a paracrine relationship during the development of the mouse embryo (41). Furthermore, expression of PDGF-AA mRNA in neurons and the ␣PDGFR message in glial cells has been shown to be developmentally regulated (66,67).…”

mentioning

confidence: 99%

Phosphorylation of Tyrosine 720 in the Platelet-Derived Growth Factor α Receptor Is Required for Binding of Grb2 and SHP-2 but Not for Activation of Ras or Cell Proliferation

Bazenet

Gelderloos

Kazlauskas

1996

Molecular and Cellular Biology

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Following binding of platelet-derived growth factor (PDGF), the PDGF ␣ receptor (␣PDGFR) becomes tyrosine phosphorylated and associates with a number of signal transduction molecules, including phospholipase C␥-1 (PLC␥-1), phosphatidylinositol 3-kinase (PI3K), the phosphotyrosine phosphatase SHP-2, Grb2, and Src. Here, we present data identifying a novel phosphorylation site in the kinase insert domain of the ␣PDGFR at tyrosine (Y) 720. We replaced this residue with phenylalanine and expressed the mutated receptor (F720) in Patch fibroblasts that do not express the ␣PDGFR. Characterization of the F720 mutant indicated that binding of two proteins, SHP-2 and Grb2, was severely impaired, whereas PLC␥-1 and PI3K associated to wild-type levels. In addition, mutating Y720 to phenylalanine dramatically reduced PDGF-dependent tyrosine phosphorylation of SHP-2. Since Y720 was required for recruitment of two proteins, we investigated the mechanism by which these two proteins associated with the ␣PDGFR. SHP-2 bound the ␣PDGFR directly, whereas Grb2 associated indirectly, most probably via SHP-2, as Grb2 and SHP-2 coimmunoprecipitated when SHP-2 was tyrosine phosphorylated. We also compared the ability of the wild-type and F720 ␣PDGFRs to mediate a number of downstream events. Preventing the ␣PDGFR from recruiting SHP-2 and Grb2 did not compromise PDGF-AA-induced activation of Ras, initiation of DNA synthesis, or growth of cells in soft agar. We conclude that phosphorylation of the ␣PDGFR at Y720 is required for association of SHP-2 and Grb2 and tyrosine phosphorylation of SHP-2; however, these events are not required for the ␣PDGFR to activate Ras or initiate a proliferative response. In addition, these findings reveal that while SHP-2 binds to both of the receptors, it binds in different locations: to the carboxy terminus of the ␤PDGFR but to the kinase insert of the ␣PDGFR.

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Expression of mouse PDGF-A and PDGF α-receptor genes during pre- and post-implantation development: Evidence for a developmental shift from an autocrine to a paracrine mode of action

Cited by 66 publications

References 39 publications

Expression of M‐twist during postimplantation development of the mouse

Expression of M‐twist during postimplantation development of the mouse

Activities of growth factors in preimplantation embryos

Phosphorylation of Tyrosine 720 in the Platelet-Derived Growth Factor α Receptor Is Required for Binding of Grb2 and SHP-2 but Not for Activation of Ras or Cell Proliferation

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