Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma

Matsukita, Sumika; Nomoto, Mitsuharu; Kitajima, Shinichi; Tanaka, Sadao; Goto, Masamichi; Irimura, Tatsuro; Kim, Y S; Sato, Erika; Yonezawa, Suguru

doi:10.1046/j.1365-2559.2003.01530.x

Cited by 103 publications

(132 citation statements)

References 36 publications

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“…The high level of the gel-forming MUC2 mucin in breast cancer may act as a barrier that interferes with extension of the malignant cells, an advantage that may explain the less aggressive behaviour of mucinous carcinoma of the breast. 23 We also found a significantly more frequent ERnegative phenotype among MUC2-positive nonmucinous tumours compared with the negative tumours. This can be explained by the relatively higher incidence of grade 3 tumours compared with grade 1 and 2 (55.8% vs 14.4 and 29.85%, respectively), which agrees with a previous study stating that MUC2 overexpression by invasive ductal carcinomas is associated with aggressive tumour behaviour.…”

Section: Discussionsupporting

confidence: 56%

“…[49][50][51] In our series, MUC2 was expressed with a very high frequency in mucinous carcinomas compared with other tumour types as previously reported. 23,30,52 A previous study has described MUC2 expression in the adjacent in situ lesions as well as adjacent and remote normal breast tissue and suggested that altered MUC2 expression pattern existing in normal breast tissue is a directional vector in histogenesis of such histological tumour type. 52 However, in this study, we could not confirm An inverse association has been identified between those tumours, excluding mucinous carcinomas, expressing MUC2 and nodal spread and vascular invasion.…”

Section: Discussionmentioning

confidence: 99%

“…22 With other mucin antibodies, positivity was defined by detection of positive expression in 45% of the malignant cells and positive expression was stratified into two groups below and above the median of expression corresponding to low and high expression. 23 In case of MUC1, additional assessment of the subcellular localization was conducted. The pattern of expression was as follows: luminal/ apical, combined luminal and cytoplasmic and cytoplasmic with circumferential membranous expression.…”

Section: Evaluation Of Immunohistochemical Stainingmentioning

confidence: 99%

“…22 Matsukita et al 23 have shown a correlation between MUC6 expression and mucinous carcinoma of the breast. Previous studies have shown no association between MUC5AC or MUC6 and tumour size, histological grade, node status or oestrogen receptor (ER) status.…”

mentioning

confidence: 98%

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Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer

et al. 2005

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Mucins are a large family of glycoproteins expressed by many epithelial cells and their malignant counterparts. Much interest has been focused on expression of its members in breast cancer because of their potential role as prognostic indicators and their involvement in cancer therapy. We have examined 1447 cases of invasive breast carcinoma with a long-term follow-up, using tissue microarray (TMA) technology and immunohistochemistry to evaluate the expression profiles of several mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and to assess their prognostic value. We detected MUC1 expression in 91% of tumours. MUC1 overexpression was associated with a lower grade, smaller tumour size, a higher oestrogen receptor (ER)-positive phenotype and absence of both regional recurrence and distance metastasis. The subcellular localization but not the level of expression had a prognostic value in predicting outcome. The aberrant cytoplasmic and membranous localization of MUC1 was associated with poor outcome compared with apical localization, which is the normal physiological site of expression. MUC2 expression was noticed in only 8.3% of all cases and was restricted to the cytoplasm of the tumour cells. An inverse trend was identified between MUC2 expression and lymph node stage and vascular invasion status. On excluding cases of mucinous carcinoma from the analysis, the inverse association with vascular invasion was still defined and in addition an inverse association with ER status emerged. MUC3 expression was detected in 91% of cases and its expression was associated with increased local recurrence, and lymph node stage. The membranous expression of MUC3 was found to be a potentially poor prognostic feature, with higher grade and poorer Nottingham Prognostic Index (NPI), and negative ER expression. MUC4, MUC5AC and MUC6 were expressed in 95, 37 and 20% of cases, respectively. Apart from an association between MUC4 expression and tumour grade and between MUC6 and ER-negative tumours, no other associations with any clinicopathological variables were found. Apart from the higher expression of MUC2 and MUC6 in mucinous carcinomas, no association was found between the expression of different mucins and tumour type. No association between the level of expression of any of the studied mucins and patient outcomes has been identified. In conclusion, most breast carcinomas express MUC1, MUC3 and MUC4. Among the various mucins expressed in breast cancer, MUC1 and MUC3 are potential prognostic indicators, MUC1 having the strongest relationship with patient outcome.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Evaluation Of Immunohistochemical Stainingmentioning

confidence: 99%

mentioning

confidence: 98%

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Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer

et al. 2005

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“…The mucin secreted has been found to be positive for MUC 2 and low level of MUC 1 14 . A very small proportion (<5%) of Mucinous carcinoma has been showing positivity for MUC 5 15 . There is one study which has described endocrine differentiation of mucinous carcinoma of breast 16 .…”

Section: Case Report Discussionmentioning

confidence: 99%

Mucinous carcinoma of breast: FNAC as effective diagnostic modality

et al. 2013

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Mucinous carcinoma of the breast in pure form comprises only 2% of all breast cancers. Pure mucinous carcinoma of the breast have better prognosis. They are usually having higher incidence in peri-menopausal and post-menopausal age group. We report a 32-year-old female, clinically suspected to have benign breast disease, diagnosed as mucinous carcinoma of the breast on FNAC. In such cases, there is always a high probability of missing the diagnosis at imaging because of the absence of established radiological signs of malignancy such as calcification and spiculation. In this case imaging was not helpful and diagnosis was ascertained by FNAC. This case further strongly substantiates, Fine needle aspiration cytology as rapid , highly sensitive and highly specific diagnostic investigation of choice for management of breast lumps .

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The molecular background of mucinous carcinoma beyond MUC2

Hugen

Simons²,

Halilović³

et al. 2014

Clin J Pathol

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The increasing interest of the oncology community in tumour classification and prediction of outcome to targeted therapies has put emphasis on an improved identification of tumour types. Colorectal mucinous adenocarcinoma (MC) is a subtype that is characterized by the presence of abundant extracellular mucin that comprises at least 50% of the tumour volume and is found in 10-15% of colorectal cancer patients. MC development is poorly understood, however, the distinct clinical and pathological presentation of MC suggests a deviant development and molecular background. In this review we identify common molecular and genetic alterations in colorectal MC. MC is characterized by a high rate of MUC2 expression. Mutation rates in the therapeutically important RAS/RAF/MAPK and PI3K/AKT pathways are significantly higher in MC compared with non-mucinous adenocarcinoma. Furthermore, mucinous adenocarcinoma shows higher rates of microsatellite instability and is more frequently of the CpG island methylator phenotype. Although the majority of MCs arise from the large intestine, this subtype also develops in other organs, such as the stomach, pancreas, biliary tract, ovary, breast and lung. We compared findings from colorectal MC with tumour characteristics of MCs from other organs. In these organs, MCs show different mutation rates in the RAS/RAF/MAPK and PI3K/ AKT pathways as well, but a common mucinous pathway cannot be identified. Identification of conditions and molecular aberrations that are associated with MC generates insight into the aetiology of this subtype and improves understanding of resistance to therapies.

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Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma

Cited by 103 publications

References 36 publications

Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer

Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer

Mucinous carcinoma of breast: FNAC as effective diagnostic modality

The molecular background of mucinous carcinoma beyond MUC2

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